Statins induce immunosuppressive effect on heterotopic limb allografts in rat through inhibiting T cell activation and proliferation

European Journal of Pharmacology

Volumn 602, Issue 1, 2009, Pages 168-175

  Nie, Chunlei ^a   Yang, Daping ^a   Liu, Guofeng ^a   Dong, Deli ^a   Ma, Zhiqiang ^a   Fu, Hailiang ^a   Zhao, Zhengyu ^a   Sun, Zhiyong ^b  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

Allograft; IFN (interferon ); IL 2 (interleukin 2); Immunosuppressive; Statins; T lymphocyte

Indexed keywords

ATORVASTATIN; CD28 ANTIGEN; CD3 ANTIGEN; CYCLOSPORIN A; GAMMA INTERFERON; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERLEUKIN 2; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BROWN NORWAY RAT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; GRAFT SURVIVAL; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; LEWIS RAT; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC INFILTRATION; MALE; MIXED LYMPHOCYTE REACTION; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD28; ANTIGENS, CD3; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HINDLIMB; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMMUNOSUPPRESSIVE AGENTS; INTERFERON-GAMMA; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MALE; RATS; RATS, INBRED BN; RATS, INBRED LEW; RNA, MESSENGER; T-LYMPHOCYTES; TIME FACTORS; TRANSCRIPTIONAL ACTIVATION; TRANSPLANTATION, HOMOLOGOUS;

EID: 57249109878     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.11.022     Document Type: Article

References (33)

1. Arnaud C., Braunersreuther V., and Mach F. Toward immunomodulatory and anti-inflammatory properties of statins. Trends. Cardiovasc. Med 15 (2005) 202-206
2. Bishop G.A., Wang C., Sharland A.F., and McCaughan G. Spontaneous acceptance of liver transplants in rodents: evidence that liver leucocytes induce recipient T-cell death by neglect. Immunol. Cell. Biol 80 (2002) 93-100
3. Blanco-Colio L.M., Tuñón J., Martín-Ventura J.L., and Egido J. Anti-inflammatory and immunomodulatory effects of statins. Kidney. Int 63 (2003) 12-23
4. Boleslawski E., Conti F., Sanquer S., Podevin P., Chouzenoux S., Batteux F., Houssin D., Weill B., and Calmus Y. Defective inhibition of peripheral CD8 + T cell IL-2 production by anti-calcineurin drugs during acute liver allograft rejection. Transplantation 77 (2004) 1815-1820
5. Cendales L.C., Kirk A.D., Moresi J.M., Ruiz P., and Kleiner D.E. Composite tissue allotransplantation: classification of clinical acute skin rejection. Transplantation 80 (2005) 1676-1680
6. Cendales L.C., Xu H., Bacher J., Eckhaus M.A., Kleiner D.E., and Kirk A.D. Composite tissue allotransplantation: development of a preclinical model in nonhuman primates. Transplantation 80 (2005) 1447-1454
7. Demir Y., Ozmen S., Klimczak A., Mukherjee A.L., and Siemionow M. Tolerance induction in composite facial allograft transplantation in the rat model. Plast. Reconstr. Surg 114 (2004) 1790-1801
8. Geissler I., Collins L., Schofield R., and Fabre J.W. In vivo suppression of major histocompatibility complex class II expression on porcine vascular endothelial cells by an HMG-CoA reductase inhibitor. Transplantation. 81 (2006) 922-926
9. Horwitz D.A., Zheng S.G., and Gray J.D. The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4+CD25+and CD8+regulatory T cell subsets. J. Leukoc. Biol 74 (2003) 471-478
10. Jiang H., Yang X.F., Wynn C., Soriano R., Krishnan K., Fujimura T., and Kobayashi M. IL-10: a tacrolimus-specific cytotoxic mediator in ongoing allograft rejection. Transplant. proc 33 (2001) 510-513
11. Kakkis J.L., Ke B., Dawson S., Maggard M., Si M., Kaldas F., Cai W., Shau H., Seu P., Sauri H., Busuttil R.W., and Imagawa D.K. Pravastatin increases survival and inhibits natural killer cell enhancement factor in liver transplanted rats. J. Surg. Res 69 (1997) 393-398
12. Kang S.S., and Allen P.M. Priming in the presence of IL-10 results in direct enhancement of CD8+ T cell primary responses and inhibition of secondary responses. J. Immunol 174 (2005) 5382-5389
13. Keogh A., Macdonald P., Kaan A., Aboyoun C., Spratt P., and Mundy J. Efficacy and safety of pravastatin vs simvastatin after cardiac transplantation. J. Heart. Lung. Transplant 19 (2000) 529-537
14. Kobashigawa J.A. Statins in solid organ transplantation: is there an immunosuppressive effect? Am. J. Transplant 4 (2004) 1013-1018
15. Kobashigawa J.A., Moriguchi J.D., Laks H., Wener L., Hage A., Hamilton M.A., Cogert G., Marquez A., Vassilakis M.E., Patel J., and Yeatman L. Ten-year follow-up of a randomized trial of pravastatin in heart transplant patients. J. Heart. Lung. Transplant 24 (2005) 1736-1740
16. Kwak B., Mulhaupt F., Myit S., and Mach F. Statins as a newly recognized type of immunomodulator. Nat. Med 6 (2000) 1399-1402
17. Lanzetta M., Petruzzo P., Margreiter R., Dubernard J.M., Schuind F., Breidenbach W., Lucchina S., Schneeberger S., van Holder C., Granger D., Pei G., Zhao J., and Zhang X. The international registry on hand and composite tissue transplantation. Transplantation 79 (2005) 1210-1214
18. Levi D.M., Tzakis A.G., Kato T., Madariaga J., Mittal N.K., Nery J., Nishida S., and Ruiz P. Transplantation of the abdominal wall. Lancet 361 (2003) 2173-2176
19. Margreiter R., Brandacher G., Ninkovic M., Steurer W., Kreczy A., and Schneeberger S. A double-hand transplant can be worth the effort. Transplantation 74 (2002) 85-90
20. Mocellin S., Panelli M.C., Wang E., Nagorsen D., and Marincola F.M. The dual role of IL-10. Trends. Immunol 24 (2003) 36-43
21. Nazzal J.A., Johnson T.S., Gordon C.R., Randolph M.A., and Lee W.P. Heterotopic limb allotransplantation model to study skin rejection in the rat. Microsurgery 24 (2004) 448-453
22. Pae H.O., Oh G.S., Choi B.M., Chae S.C., Kim Y.M., Chung K.R., and Chung H.T. Carbon monoxide produced by heme oxygenase-1 suppresses T cell proliferation via inhibition of IL-2 production. J. Immunol 172 (2004) 4744-4751
23. Qian S., Lu L., Fu F., Li Y., Li W., Starzl T.E., Fung J.J., and Thomson A.W. Apoptosis within spontaneously accepted mouse liver allografts: evidence for deletion of cytotoxic T cells and implications for tolerance induction. J. Immunol 158 (1997) 4654-4661
24. Raggatt L.J., and Partridge N.C. HMG-CoA reductase inhibitors as immunomodulators: potential use in transplant rejection. Drugs 62 (2002) 2185-2191
25. Ruschpler P., and Stiehl P. Shift in Th1 (IL-2 and IFN-gamma) and Th2 (IL-10 and IL-4) cytokine mRNA balance within two new histological main-types of rheumatoid-arthritis (RA). Cell. Mol. Biol 48 (2002) 285-293
26. Sabbatini M., Pisani A., Uccello F., Serio V., Serù R., Paternò R., Cianciaruso B., Fuiano G., and Andreucci M. Atorvastatin improves the course of ischemic acute renal failure in aging rats. J. Am. Soc. Nephrol 15 (2004) 901-909
27. Sharland A., Shastry S., Wang C., Rokahr K., Sun J., Sheil A.G., McCaughan G.W., and Bishop G.A. Kinetics of intragraft cytokine expression, cellular infiltration, and cell death in rejection of renal allografts compared with acceptance of liver allografts in a rat model: early activation and apoptosis is associated with liver graft acceptance. Transplantation 65 (1998) 1370-1377
28. Steffens S., and Mach F. Drug insight: immunomodulatory effects of statins-potential benefits for renal patients?. Nat. Clin. Pract. Nephrol 2 (2006) 378-387
29. Suzuki J., Koga N., Kosuge H., Ogawa M., Haraguchi G., Maejima Y., Saiki H., and Isobe M. Pitavastatin suppresses acute and chronic rejection in murine cardiac allografts. Transplantation 83 (2007) 1093-1097
30. Tewari K., Nakayama Y., and Suresh M. Role of direct effects of IFN-gamma on T cells in the regulation of CD8 T cell homeostasis. J. Immunol 179 (2007) 2115-2125
31. Weis M., Pehlivanli S., Meiser B.M., and von Scheidt W. Simvastatin treatment is associated with improvement in coronary endothelial function and decreased cytokine activation in patients after heart transplantation. J. Am. Coll. Cardiol 38 (2001) 814-818
32. Weitz-Schmidt G., Welzenbach K., Brinkmann V., Kamata T., Kallen J., Bruns C., Cottens S., Takada Y., and Hommel U. Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat. Med 7 (2001) 687-692
33. Wong P., and Pamer E.G. Disparate in vitro and in vivo requirements for IL-2 during antigen-independent CD8 T cell expansion. J. Immunol 172 (2004) 2171-2176