Recombinant carcinoembryonic antigen as a reporter gene for molecular imaging

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 36, Issue 1, 2009, Pages 104-114

  Kenanova, Vania ^a   Barat, Bhaswati ^a   Olafsen, Tove ^a   Chatziioannou, Arion ^a   Herschman, Harvey R ^a   Braun, Jonathan ^a   Wu, Anna M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

124I labeled scFv Fc antibody fragment; CEA reporter gene; Jurkat xenograft; MicroPET microCT imaging; T cells

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; FC RECEPTOR IIB; IODINE 124; RECOMBINANT CARCINOEMBRYONIC ANTIGE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; FLOW CYTOMETRY; GENE; GENE ACTIVITY; GENE CONSTRUCT; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOGENICITY; IMMUNOHISTOCHEMISTRY; LEUKEMIA CELL LINE; MOLECULAR IMAGING; MOUSE; N A3 GENE; NONHUMAN; NUDE MOUSE; POSITRON EMISSION TOMOGRAPHY; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RADIOIODINATION; RECOMBINANT GENE; REPORTER GENE; T CELL LEUKEMIA; WESTERN BLOTTING;

ANIMALS; CARCINOEMBRYONIC ANTIGEN; CELL LINE; GENES, REPORTER; HUMANS; IMMUNOGLOBULIN FRAGMENTS; ISOANTIGENS; MICE; NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, IGG; RECOMBINANT PROTEINS; T-LYMPHOCYTES; TOMOGRAPHY, X-RAY COMPUTED;

EID: 57249094338     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-008-0921-z     Document Type: Article

References (40)

1. J Alam JL Cook 1990 Reporter genes: application to the study of mammalian gene transcription Anal Biochem 188 2 245 254
2. I Serganova R Blasberg 2005 Reporter gene imaging: potential impact on therapy Nucl Med Biol 32 7 763 780
3. JG Tjuvajev M Doubrovin T Akhurst S Cai J Balatoni MM Alauddin 2002 Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression J Nucl Med 43 8 1072 1083
4. DC MacLaren SS Gambhir N Satyamurthy JR Barrio S Sharfstein T Toyokuni 1999 Repetitive, non-invasive imaging of the dopamine D2 receptor as a reporter gene in living animals Gene Ther 6 5 785 791
5. E Ur J Bomanji SJ Mather KE Britton JA Wass AB Grossman 1993 Localization of neuroendocrine tumours and insulinomas using radiolabelled somatostatin analogues, 123I-Tyr3-octreotide and 111In-pentatreotide Clin Endocrinol (Oxf) 38 5 501 506
6. U Haberkorn M Henze A Altmann S Jiang I Morr M Mahmut 2001 Transfer of the human NaI symporter gene enhances iodide uptake in hepatoma cells J Nucl Med 42 2 317 325
7. A Altmann M Kissel S Zitzmann W Kubler M Mahmut P Peschke 2003 Increased MIBG uptake after transfer of the human norepinephrine transporter gene in rat hepatoma J Nucl Med 44 6 973 980
8. C Bonini G Ferrari S Verzeletti P Servida E Zappone L Ruggieri 1997 HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia Science 276 5319 1719 1724
9. S Verzeletti C Bonini S Marktel N Nobili F Ciceri C Traversari 1998 Herpes simplex virus thymidine kinase gene transfer for controlled graft-versus-host disease and graft-versus-leukemia: clinical follow-up and improved new vectors Hum Gene Ther 9 15 2243 2251
10. Q Liang N Satyamurthy JR Barrio T Toyokuni MP Phelps SS Gambhir 2001 Noninvasive, quantitative imaging in living animals of a mutant dopamine D2 receptor reporter gene in which ligand binding is uncoupled from signal transduction Gene Ther 8 19 1490 1498
11. RA Ajjan NA Kamaruddin M Crisp PF Watson M Ludgate AP Weetman 1998 Regulation and tissue distribution of the human sodium iodide symporter gene Clin Endocrinol (Oxf) 49 4 517 523
12. PA Smanik KY Ryu KS Theil EL Mazzaferri SM Jhiang 1997 Expression, exon-intron organization, and chromosome mapping of the human sodium iodide symporter Endocrinology 138 8 3555 3558
13. C Spitzweg W Joba W Eisenmenger AE Heufelder 1998 Analysis of human sodium iodide symporter gene expression in extrathyroidal tissues and cloning of its complementary deoxyribonucleic acids from salivary gland, mammary gland, and gastric mucosa J Clin Endocrinol Metab 83 5 1746 1751
14. I Serganova V Ponomarev R Blasberg 2007 Human reporter genes: potential use in clinical studies Nucl Med Biol 34 7 791 807
15. P Dubey H Su N Adonai S Du A Rosato J Braun 2003 Quantitative imaging of the T cell antitumor response by positron-emission tomography Proc Natl Acad Sci U S A 100 3 1232 1237
16. G Koehne M Doubrovin E Doubrovina P Zanzonico HF Gallardo A Ivanova 2003 Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes Nat Biotechnol 21 4 405 413
17. S Benchimol A Fuks S Jothy N Beauchemin K Shirota CP Stanners 1989 Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule Cell 57 2 327 334
18. JE Shively JD Beatty 1985 CEA-related antigens: molecular biology and clinical significance Crit Rev Oncol Hematol 2 4 355 399
19. CA Toth P Thomas SA Broitman N Zamcheck 1985 Receptor-mediated endocytosis of carcinoembryonic antigen by rat liver Kupffer cells Cancer Res 45 1 392 397
20. D Raben DJ Buchsbaum MB Khazaeli ME Rosenfeld GY Gillespie WE Grizzle 1996 Enhancement of radiolabeled antibody binding and tumor localization through adenoviral transduction of the human carcinoembryonic antigen gene Gene Ther 3 7 567 580
21. V Kenanova T Olafsen DM Crow G Sundaresan M Subbarayan NH Carter 2005 Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments Cancer Res 65 2 622 631
22. YH You LJ Hefta PJ Yazaki AM Wu JE Shively 1998 Expression, purification, and characterization of a two domain carcinoembryonic antigen minigene (N-A3) in Pichia pastoris. The essential role of the N-domain Anticancer Res 18 5A 3193 3201
23. H Schrewe J Thompson M Bona LJ Hefta A Maruya M Hassauer 1990 Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression Mol Cell Biol 10 6 2738 2748
24. DG Brooks WQ Qiu AD Luster JV Ravetch 1989 Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes J Exp Med 170 4 1369 1385
25. T Olafsen VE Kenanova AM Wu 2006 Tunable pharmacokinetics: modifying the in vivo half-life of antibodies by directed mutagenesis of the Fc fragment Nat Protoc 1 4 2048 2060
26. M Neumaier L Shively FS Chen FJ Gaida C Ilgen RJ Paxton 1990 Cloning of the genes for T84.66, an antibody that has a high specificity and affinity for carcinoembryonic antigen, and expression of chimeric human/mouse T84.66 genes in myeloma and Chinese hamster ovary cells Cancer Res 50 7 2128 2134
27. DM Neville Jr. J Scharff K Srinivasachar 1992 In vivo T-cell ablation by a holo-immunotoxin directed at human CD3 Proc Natl Acad Sci U S A 89 7 2585 2589
28. M Defrise PE Kinahan DW Townsend C Michel M Sibomana DF Newport 1997 Exact and approximate rebinning algorithms for 3-D PET data IEEE Trans Med Imaging 16 2 145 158
29. AM Loening SS Gambhir 2003 AMIDE: a free software tool for multimodality medical image analysis Mol Imaging 2 3 131 137
30. JV Ravetch S Bolland 2001 IgG Fc receptors Annu Rev Immunol 19 275 290
31. JA Thompson F Grunert W Zimmermann 1991 Carcinoembryonic antigen gene family: molecular biology and clinical perspectives J Clin Lab Anal 5 5 344 366
32. DA Berk F Yuan M Leunig RK Jain 1997 Direct in vivo measurement of targeted binding in a human tumor xenograft Proc Natl Acad Sci U S A 94 5 1785 1790
33. V Kenanova T Olafsen LE Williams NH Ruel J Longmate PJ Yazaki 2007 Radioiodinated versus radiometal-labeled anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments: optimal pharmacokinetics for therapy Cancer Res 67 2 718 726
34. MR Zalutsky MA Noska EV Colapinto PK Garg DD Bigner 1989 Enhanced tumor localization and in vivo stability of a monoclonal antibody radioiodinated using N-succinimidyl 3-(tri-n-butylstannyl)benzoate Cancer Res 49 20 5543 5549
35. F Geissler SK Anderson P Venkatesan O Press 1992 Intracellular catabolism of radiolabeled anti-mu antibodies by malignant B-cells Cancer Res 52 10 2907 2915
36. S Yaghoubi JR Barrio M Dahlbom M Iyer M Namavari N Satyamurthy 2001 Human pharmacokinetic and dosimetry studies of [(18)F]FHBG: a reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression J Nucl Med 42 8 1225 1234
37. J Voges R Reszka A Gossmann C Dittmar R Richter G Garlip 2003 Imaging-guided convection-enhanced delivery and gene therapy of glioblastoma Ann Neurol 54 4 479 487
38. A Gangopadhyay P Thomas 1996 Processing of carcinoembryonic antigen by Kupffer cells: recognition of a penta-peptide sequence Arch Biochem Biophys 334 1 151 157
39. JV Ravetch JP Kinet 1991 Fc receptors Annu Rev Immunol 9 457 492
40. MD Hulett E Witort RI Brinkworth IF McKenzie PM Hogarth 1994 Identification of the IgG binding site of the human low affinity receptor for IgG Fc gamma RII. Enhancement and ablation of binding by site-directed mutagenesis J Biol Chem 269 21 15287 15293