The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder

Neuroendocrinology Letters

Volumn 29, Issue 5, 2008, Pages 759-762

  Soukup, Ondrej ^a   Pohanka, Miroslav ^a   Tobin, Gunnar ^c   Jun, Daniel ^a,b   Fusek, Josef ^a   Musilek, Kamil ^a   Marek, Jan ^a   Kassa, Jiri ^a   Kuca, Kamil ^a  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Cholinesterase; HI 6; IC50; In vitro; Inhibition; Muscarinic; Receptor

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ACETYLCHOLINESTERASE; CHOLINERGIC RECEPTOR; METHACHOLINE; MUSCARINIC RECEPTOR; ORGANOPHOSPHATE; OXIME;

ANIMAL TISSUE; ARTICLE; BIOSENSOR; BLADDER; CHOLINERGIC SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; ENZYME INHIBITION; ERYTHROCYTE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INTOXICATION; NONHUMAN; RAT; SERUM;

EID: 57149148411     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Abrams P, Andersson KE, Buccafusco JJ, Chapple C, de Groat WC, Fryer AD, et al., (2006). "Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder." Br J Pharmacol 148(5): 565-78.
2. Bajgar J (2004). "Organophosphates/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis, and treatment." Adv Clin Chem 38: 151-216.
3. Collins SM and Crankshaw DJ (1986). "Dissociation of contraction and muscarinic receptor binding to isolated smooth muscle cells." Am J Physiol 251(4 Pt 1): G546-52.
4. Giglio D, Aronsson P, Eriksson L and Tobin G (2007). "In vitro characterization of parasympathetic and sympathetic responses in cyclophosphamide-induced cystitis in the rat." Basic Clin Pharmacol Toxicol 100(2): 96-108.
5. Grossmuller M, Antony J, Trankle C, Holzgrabe U and Mohr K (2006). "Allosteric site in M2 acetylcholine receptors: evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist." Naunyn Schmiedebergs Arch Pharmacol 372(4): 267-76.
6. Hamilton MG and Lundy PM (1989). "HI-6 therapy of soman and tabun poisoning in primates and rodents." Arch Toxicol 63(2): 144-9.
7. Kassa J (2002). "Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents." J Toxicol Clin Toxicol 40(6): 803-16.
8. Kassa J, Kuca K, Cabal J and Paar M (2006). "A comparison of the efficacy of new asymmetric bispyridinium oximes (K027, K048) with currently available oximes against tabun by in vivo methods." J Toxicol Environ Health A 69(20): 1875-82.
9. Kuca K, Jun D, Musilek K and Bajgar J (2007). "Reactivators of Tabun-Inhibited Acetylcholinesterase:Structure-Biological Activity Relationship." Frontiers in Drug Design and Discovery(3): 381-394.
10. Kuhnen-Clausen D, Hagedorn I, Gross G, Bayer H and Hucho F (1983). "Interactions of bisquaternary pyridine salts (H-oximes) with cholinergic receptors." Arch Toxicol 54(3): 171-9.
11. Loke WK, Sim MK and Go ML (2002). "O-Substituted derivatives of pralidoxime: muscarinic properties and protection against soman effects in rats." Eur J Pharmacol 442(3): 279-87.
12. Lundy PM and Tremblay KP (1979). "Ganglion blocking properties of some bispyridinium soman antagonists." Eur J Pharmacol 60(1): 47-53.
13. Marrs TC (1993). "Organophosphate poisoning." Pharmacol Ther 58(1): 51-66.
14. Pohanka M, Kuca K and Jun D (2007). "Amperometric biosensor for pesticide methamidophos assay." Acta Medica (Hradec Kralove) 50(4): 239-41.
15. Puu G, Artursson E and Bucht G (1986). "Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime." Biochem Pharmacol 35(9):1505-10.
16. Tattersall JE (1993). "Ion channel blockade by oximes and recovery of diaphragm muscle from soman poisoning in vitro." Br J Pharmacol 108(4): 1006-15.
17. Trankle C, Dittmann A, Schulz U, Weyand O, Buller S, Johren K, et al., (2005). "Atypical muscarinic allosteric modulation: cooperativity between modulators and their atypical binding topology in muscarinic M2 and M2/M5 chimeric receptors." Mol Pharmacol 68(6): 1597-610.