Activation of cAMP signaling enhances Fas-mediated apoptosis and activation-induced cell death through potentiation of caspase 8 activation

Human Immunology

Volumn 69, Issue 12, 2008, Pages 833-836

  Naderi, Soheil ^a   Blomhoff, Heidi Kiil ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

AICD; Apoptosis; cAMP; Fas; T cells

Indexed keywords

ADENYLATE CYCLASE; CASPASE 8; CYCLIC AMP; FAS ANTIBODY; FAS ANTIGEN; FORSKOLIN; ISOBUTYLMETHYLXANTHINE; PROSTAGLANDIN E2;

APOPTOSIS; ARTICLE; CELL DEATH; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ADENYLATE CYCLASE; APOPTOSIS; CASPASE 8; CD4-POSITIVE T-LYMPHOCYTES; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS; ENZYME ACTIVATION; FORSKOLIN; HUMANS; JURKAT CELLS; PHYTOHEMAGGLUTININS; PYROPHOSPHATASES; SIGNAL TRANSDUCTION;

EID: 57149142653     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2008.09.005     Document Type: Article

References (21)

1. Krueger A., Fas S.C., Baumann S., and Krammer P.H. The role of CD95 in the regulation of peripheral T-cell apoptosis. Immunol Rev 193 (2002) 58-69
2. Nagata S. Fas ligand-induced apoptosis. Annu Rev Genet 33 (1999) 29-55
3. Fas S.C., Fritzsching B., Suri-Payer E., and Krammer P.H. Death receptor signaling and its function in the immune system. Curr Dir Autoimmun 9 (2006) 1-17
4. Peter M.E., and Krammer P.H. The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ 10 (2003) 26-35
5. Tasken K., and Ruppelt A. Negative regulation of T-cell receptor activation by the cAMP-PKA-Csk signaling pathway in T-cell lipid rafts. Front Biosci 11 (2006) 2929-2939
6. Naderi S., Gutzkow K.B., Christoffersen J., Smeland E.B., and Blomhoff H.K. cAMP-mediated growth inhibition of lymphoid cells in G1: Rapid down-regulation of cyclin D3 at the level of translation. Eur J Immunol 30 (2000) 1757-1768
7. Gutzkow K.B., Lahne H.U., Naderi S., Torgersen K.M., Skalhegg B., Koketsu M., et al. Cyclic AMP inhibits translation of cyclin D3 in T lymphocytes at the level of elongation by inducing eEF2-phosphorylation. Cell Signal 15 (2003) 871-881
8. Engedal N., Gjevik T., Blomhoff R., and Blomhoff H.K. All-trans retinoic acid stimulates IL-2-mediated proliferation of human T lymphocytes: Early induction of cyclin D3. J Immunol 177 (2006) 2851-2861
9. Naderi S., Wang J.Y., Chen T.T., Gutzkow K.B., and Blomhoff H.K. cAMP-mediated inhibition of DNA replication and S phase progression: Involvement of Rb, p21Cip1, and PCNA. Mol Biol Cell 16 (2005) 1527-1542
10. Engedal N., and Blomhoff H.K. Combined action of ERK and NF kappa B mediates the protective effect of phorbol ester on Fas-induced apoptosis in Jurkat cells. J Biol Chem 278 (2003) 10934-10941
11. Scaffidi C., Krammer P.H., and Peter M.E. Isolation and analysis of components of CD95 (APO-1/Fas) death-inducing signaling complex. Methods 17 (1999) 287-291
12. Seamon K.B., and Daly J.W. Forskolin. A unique diterpene activator of cyclic AMP-generating systems. J Cyclic Nucleotide Res 7 (1981) 201-224
13. Joost H.G., and Steinfelder H.J. Forskolin inhibits insulin-stimulated glucose transport in rat adipose cells by a direct interaction with the glucose transporter. Mol Pharmacol 31 (1987) 279-283
14. Laurenza A., Sutkowski E.M., and Seamon K.B. Forskolin. A specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?. Trends Pharmacol Sci 10 (1989) 442-447
15. Negishi M., Sugimoto Y., and Ichikawa A. Prostanoid receptors and their biological actions. Prog Lipid Res 32 (1993) 417-434
16. Coleman R.A., Smith W.L., and Narumiya S. International Union of Pharmacology classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev 46 (1994) 205-229
17. Beavo J.A., Rogers N.L., Crofford O.B., Hardman J.G., Sutherland E.W., and Newman E.V. Effects of xanthine derivatives on lipolysis and on adenosine 3′,5′-monophosphate phosphodiesterase activity. Mol Pharmacol 6 (1970) 597-603
18. Beavo J.A., and Reifsnyder D.H. Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors. Trends Pharmacol Sci 11 (1990) 150-155
19. Hsu S.C., Wu C.C., Luh T.Y., Chou C.K., Han S.H., and Lai M.Z. Apoptotic signal of Fas is not mediated by ceramide. Blood 91 (1998) 2658-2663
20. Walczak H., and Krammer P.H. The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems. Exp Cell Res 256 (2000) 58-66
21. Arnold R., Brenner D., Becker M., Frey C.R., and Krammer P.H. How T lymphocytes switch between life and death. Eur J Immunol 36 (2006) 1654-1658