Potential antioxidant activity, cytotoxic and apoptosis-inducing effects of Chelidonium majus L. extract on leukemia cells

Neuroendocrinology Letters

Volumn 29, Issue 5, 2008, Pages 649-652

  Nadova, Slavomira ^a   Miadokova, Eva ^a   Alfoldiova, Lubica ^a   Kopaskova, Marcela ^a   Hasplova, Katarina ^a   Hudecova, Alexandra ^a   Vaculcikova, Dagmar ^b   Gregan, Fridrich ^b   Cipak, Lubos ^c  

^a Physics and Informatics   (Slovakia)

^b MATEJ BEL UNIVERSITY   (Slovakia)

^c CANCER RESEARCH INSTITUTE   (Slovakia)

Author keywords

Antiproliferative effects; Apoptosis; Chelidonium majus L.; DPPH; Fluorescence microscopy; Leukemia cells

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; CHELIDONIUM EXTRACT;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER PREVENTION; CELL ASSAY; CELL STRAIN HL 60; CHEMOPROPHYLAXIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; LEUKEMIA L 1210; NONHUMAN; SOLVENT EXTRACTION;

EID: 57149125321     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Barreto MC, Pinto RE, Arrabaca JD, Pavao ML (2003). Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids. Toxicol Lett. 146: 37-47.
2. Colombo ML, Bosisio E (1996). Pharmacological activities of Chelidonium majus L. (Papaveraceae). Pharmacol Res. 33: 127-134.
3. Fischer U, Schulze-Osthoff K (2005). New approaches and therapeutics targeting apoptosis in disease. Pharmacol Rev. 57: 187-215.
4. Guner D, Belka C, Daniel PT (2003). Disruption of cell death signaling in cancer: impact on disease prognosis and response to therapy. Curr Med Chem Anti-Cancer Agents. 3: 319-326.
5. Horvathova E, Sramkova M, Labaj J, Slamenova D (2006). Study of cytotoxic, genotoxic and DNA-protective effects of selected plant essential oils on human cells cultured in vitro. Neuroendocrinol Lett. 27: 44-47.
6. Jantova S, Cipak L, Letasiova S (2007). Berberine induces apoptosis through a mitochondrial/caspase pathway in human promonocytic U937 cells. Toxicol In Vitro. 21: 25-31.
7. Kaminskyy V, Lin K-W, Filyak Y, Stoika R (2008). Differential effect of sanguinarine, chelerythrine and chelidonine on DNA damage and cell viability in primary mouse spleen cells and mouse leukemic cells. Cell Biol Int. 32: 271-277.
8. Lee Y-Ch, Kim S-H, Roh S-S, Choi H-Y, Seo Y-B (2007). Suppressive effects of Chelidonium majus methanol extract in knee joint, regional lymph nodes, and spleen on colagen-induced arthritis in mice. J Ethnopharmacology. 112:40-48.
9. Miadokova E, Nadova S, Trebaticka M, Grolmus J, Kopaskova M, Rauko P, et al. (2006). Research on biomodulatory effect of natural compounds. Neuroendocrinol Lett. 27: 53-56.
10. Miadokova E, Nadova S, Vlckova V, Duhova V, Kopaskova M, Cipak L, et al. (2008). Antigenotoxic effect of extract from Cynara cardunculus L.. Phytother Res. 22: 77-81.
11. Nadova S, Miadokova E, Cipak L (2007). Flavonoids potentiate the efficacy of cytarabine through modulation of drug-induced apoptosis. Neoplasma. 54: 202-206.
12. Nawrot R, Wolun-Cholewa M, Gozdzicka-Jozefiak A (2008). Nucleases isolated from Chelidonium majus L. milky sap can induce apoptosis in human cervical carcinoma HeLa cells but not in Chinese hamster ovary CHO cells. Folia Histochem Cytobiol. 46: 79-83.
13. Staruchova M, Volkovova K, Lajdova A, Mislanova C, Collins A, Wsolova L, et al. (2006). Importance of diet in protection against oxidative damage. Neuroendocrinol Lett. 27: 112-115.
14. Sturm I, Bosanquet AG, Hermann S, Guner D, Dorken B, Daniel PT (2003). Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy. Cell Death Differ. 10: 477-484.
15. Tagashira T, Ohtake Y (1998). A new antioxidative 1,3-benzodioxole from Melissa officinalis. Planta Med. 64: 555-558.
16. Then M, Szentmihalyi, Sarkozi A, Varga IS (2003). Examination on antioxidant activity in the greater celandine (Chelidonium majus L.) extracts by FRAP method. Act Biol Szeg. 47: 115-117.
17. Tome F, Colombo ML (1995). Distribution of alkaloids in Chelidonium majus and factors affecting their accumulation. Phytochemistry. 40: 37-39.