Structural determinants of Kvβ1.3-induced channel inactivation: A hairpin modulated by PIP2

EMBO Journal

Volumn 27, Issue 23, 2008, Pages 3164-3174

  Decher, Niels ^a,b   Gonzalez, Teresa ^a,d   Streit, Anne Kathrin ^b   Sachse, Frank B ^a   Renigunta, Vijay ^b   Soom, Malle ^c   Heinemann, Stefan H ^c   Daut, Jürgen ^b   Sanguinetti, Michael C ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^d INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

Author keywords

Ion channel; Kv ; N type inactivation; Phospholipids; Potassium

Indexed keywords

IONOMYCIN; PHOSPHOLIPID; SHAKER POTASSIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL; KCNAB1 PROTEIN, HUMAN; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; POTASSIUM CHANNEL KV1.3; POTASSIUM CHANNEL KV1.5; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CALCIUM CELL LEVEL; CHANNEL GATING; CHEMICAL MODIFICATION; CONTROLLED STUDY; MOLECULAR BIOLOGY; MOLECULAR DOCKING; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PHOSPHORYLATION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; VOLTAGE CLAMP; WILD TYPE; XENOPUS; AMINO ACID SUBSTITUTION; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; MISSENSE MUTATION; MOLECULAR GENETICS; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN QUATERNARY STRUCTURE;

PIPS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; KV1.3 POTASSIUM CHANNEL; KV1.5 POTASSIUM CHANNEL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; MUTATION, MISSENSE; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, QUATERNARY;

EID: 57149103679     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2008.231     Document Type: Article

References (28)

1. + channels: from cartoon to structure. News Physiol Sci 13: 177-182
2. Antz C, Geyer M, Fakler B, Schott MK, Guy HR, Frank R, Ruppersberg JP, Kalbitzer HR (1997) NMR structure of inactivation gates from mammalian voltage-dependent potassium channels. Nature 385: 272-275
3. Claiborne A, Mallett TC, Yeh JI, Luba J, Parsonage D (2001) Structural, redox, and mechanistic parameters for cysteine-sulfenic acid function in catalysis and regulation. Adv Protein Chem 58: 215-276
4. Decher N, Kumar P, Gonzalez T, Renigunta V, Sanguinetti MC (2005) Structural basis for competition between drug binding and Kvbeta 1.3 accessory subunit-induced N-type inactivation of Kv1.5 channels. Mol Pharmacol 68: 995-1005
5. + channels. J Biol Chem 279: 394-400
6. Encinar JA, Fernandez AM, Molina ML, Molina A, Poveda JA, Albar JP, Lopez-Barneo J, Gavilanes F, Ferrer-Montiel AV, Gonzalez-Ros JM (2002) Tyrosine phosphorylation of the inactivating peptide of the shaker B potassium channel: a structural-functional correlate. Biochemistry 41: 12263-12269
7. + channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing. J Biol Chem 270: 28531-28534
8. Fernandez-Ballester G, Gavilanes F, Albar JP, Criado M, Ferragut JA, Gonzalez-Ros JM (1995) Adoption of beta structure by the inactivating 'ball' peptide of the Shaker B potassium channel. Biophys J 68: 858-865
9. Gonzalez T, Navarro-Polanco R, Arias C, Caballero R, Moreno I, Delpon E, Tamargo J, Tamkun MM, Valenzuela C (2002) Assembly with the Kvbeta1.3 subunit modulates drug block of hKv1.5 channels. Mol Pharmacol 62: 1456-1463
10. + channels. Science 289: 123-127
11. Heinemann SH, Rettig J, Graack HR, Pongs O (1996) Functional characterization of Kv channel beta-subunits from rat brain. J Physiol 493 (Part 3): 625-633
12. + channel pore through mutant cycles with a peptide inhibitor. Science 268: 307-310
13. Hoshi T, Zagotta WN, Aldrich RW(1990) Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 250: 533-538
14. + channels. Proc Natl Acad Sci USA 101: 15535-15540
15. + channel function by the Kvbeta1.3 subunit. J Biol Chem 274: 25355-25361
16. Lee CW, Aldrich RW, Gierasch LM (1993) Conformational studies of the N-terminal domain of the shaker B potassium channel by CD and NMR. Biophys J 61: 379a (Abstract)
17. Leicher T, Bahring R, Isbrandt D, Pongs O (1998) Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel. J Biol Chem 273: 35095-35101
18. + channels by membrane lipids. Science 304: 265-270
19. 2 and receptors coupled to phospholipase C. Pflugers Arch 455: 125-145
20. Poole LB, Karplus PA, Claiborne A (2004) Protein sulfenic acids in redox signaling. Annu Rev Pharmacol Toxicol 44: 325-347
21. Putzke C, Wemhoner K, Sachse FB, Rinne S, Schlichthorl G, Li XT, Jae L, Eckhardt I, Wischmeyer E, Wulf H, Preisig-Muller R, Daut J, Decher N (2007) The acid-sensitive potassium channel TASK-1 in rat cardiac muscle. Cardiovasc Res 75: 59-68
22. + channels altered by presence of beta-subunit. Nature 369: 289-294
23. Ruppersberg JP, Stocker M, Pongs O, Heinemann SH, Frank R, Koenen M (1991) Regulation of fast inactivation of cloned mammalian IK(A) channels by cysteine oxidation. Nature 352: 711-714
24. Soom M, Schonherr R, Kubo Y, Kirsch C, Klinger R, Heinemann SH (2001) Multiple PIP2 binding sites in Kir2.1 inwardly rectifying potassium channels. FEBS Lett 490: 49-53
25. Stephens GJ, Robertson B (1995) Inactivation of the cloned potassium channel mouse Kv1.1 by the human Kv3.4 'ball' peptide and its chemical modification. J Physiol 484 (Part 1): 1-13
26. Stuhmer W (1992) Electrophysiological recording from Xenopus oocytes. Methods Enzymol 207: 319-339
27. + channel Kv beta 1.3 beta-subunit affect voltage-dependent gating. Am J Physiol 274: C1485-C1495
28. Zhou M, Morais-Cabral JH, Mann S, MacKinnon R (2001) Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors. Nature 411: 657-661