Identification and comparison of metabolites after oral administration of essential oil of Ligusticum chuanxiong or its major constituent ligustilide in rats

Planta Medica

Volumn 74, Issue 14, 2008, Pages 1684-1692

  Ding, Chunguang ^a   Sheng, Yuxin ^a   Zhang, Yinghao ^a   Zhang, Jinlan ^a   Du, Cuanhua ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Essential oil; FT ICR MS; Ligusticum chuanxiong Hort.; Ligustilide; Metabolism; Umbelliferae

Indexed keywords

3,5 DIHYDROXY 3 BUTYLPHTHALIDE; 5 HYDROXY 3 BUTYLIDENEPHTHALIDE; 6,7 DIHYDRO 6 HYDROXY 7 SULFMETHYLLIGUSTILIDE; 6,7 DIHYDRO 6,7 DIHYDROXYLIGUSTILIDE; DRUG METABOLITE; ESSENTIAL OIL; LIGUSTICUM CHUANXIONG EXTRACT; LIGUSTILIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHINESE MEDICINE; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG DETERMINATION; DRUG FECES LEVEL; DRUG METABOLISM; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION CYCLOTRON RESONANCE MASS SPECTROMETRY; LIGUSTICUM CHUANXIONG; MALE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

4-BUTYROLACTONE; ADMINISTRATION, ORAL; ANIMALS; DRUGS, CHINESE HERBAL; MALE; MOLECULAR STRUCTURE; OILS, VOLATILE; PLANT OILS; RATS; RATS, WISTAR;

APIACEAE; LIGUSTICUM CHUANXIONG; RATTUS;

EID: 57149099201     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0028-1088309     Document Type: Article

References (25)

1. Yang JR, Li ZL, Hu R, Song J. The antipyretic effect of the essential oil of Ligusticum chuanxiong Hort, on endotoxin-induced fever and hypothalamic content of 5-HT, DA in rabbit. Sichuan Physiol Sci 2001; 23: 130-1
2. Yang JR, Li ZL, Hu R, Song J. The antipyretic effect of the essential oil of Ligusticum chuanxiong Hort, on endotoxin-induced fever and hypothalamic content of monoamine neurotransmitter in rabbit. Pharmacol Clin Chin Mater Med 2003; 19: 17-9
3. Li ZL, Yang JR, Hu R, Song J. Studies on the antipyretic effect and the mechanism of the essential oil of Ligusticum chuanxiong Hort. Inf Trad Chin Med 2003; 20: 31-2
4. κB activation. Planta Med 2005; 71: 808-13
5. Xin ZhM, Zhou XM. Studies on pharmacological action and clinical application of preparation of Chuanxiong. Hebei Med J 1999; 21:41-2
6. Hou DP, Zhang W, Kang TJ. The discussion of drug property and clinical application of Chuanxiong. J Chin Med Pharmacol 1996; 1: 44-5
7. Wei QX, Zhou DW. The pharmacological and pharmacodynamic action of Chuanxiong. World Notes Plant Med 1994; 9: 164-6
8. Ozaki Y, Sekita S, Harada M. Centrally acting muscle relaxant effect of phthalides (ligustilide, cnidilide and senkyunolide) obtained from Cnidium officinale Makino. Yakugaku Zasshi 1989; 109: 402-6
9. Gao LH, Hu J, Zheng XM, Zhang WG, Wei ZW. Stability of Chuanxiong extract and its influence on blood platelet aggregation in rabbit. Pharm Care Res 2004; 4: 215-7
10. Shi YM, Zhang YL, Zheng HM. Empirical study and clinical application of activating blood circulation to dissipate blood stasis action of Chuanxiong. Med J Chin PLA 1979; 4: 98-103
11. Liang RX, Xiao YQ, Gao W. Chuanxiong-pathalide A-induced preconditioning in isolated Langendorff rat hearts. Pharmacol Clin Chin Mater Med 2004; 20: 1-3
12. Liang MJ, He LC, Yang CD. Screening, analysis and in vitro vasodilatation of effective components from Ligusticum chuanxiong. Life Sci 2005; 78: 128-33
13. Tian JW, Fu FH, Jiang WL, Wang ChY, Sun F, Zhang TP. Protective effect of Ligusticum chuanxiong phthalides on focal cerebral ischemia in rats and its related mechanism of action. China J Chin Mater Med 2005; 30: 466-8
14. Chen YH, Mo SZ, Li JY, Ge FH. Study on chemical constituents of Rhizoma Chuanxiong volatile oil. J Chin Med Mater 2004; 27: 580-2
15. Hong Y, Ji F. A study of the volatile chemical ingredients in Ligusticum chuanxiong Hort. China Pharm 2003; 12: 31-2
16. Ding MY, Ma SW, Liu DL. Comparison of volatile oil in Ligusticum chuanxiong and Angelica sinensis. Life Sci Instrum 2005; 3: 38-41
17. Du J, Yu Y, Ke Y, Wang C, Zhu L, Qian ZM. Ligustilide attenuates pain behavior induced by acetic acid or formalin. 2007; 112: 211-4
18. Naito T, Kubota K, Shimoda Y, Sato T, Ikeya Y, Okada M et al. Effects of constituents in a Chinese crude drug, Ligusticum chuanxiong rhizoma on vasoconstriction and blood viscosity. Nat Med 1995; 49: 288-92
19. Lu Q, Qiu TQ, Yang H. Ligustilide inhibits vascular smooth muscle cell proliferation. Eur J Pharmacol 2006; 542: 136-40
20. 2+ influx and release. Vascul Pharmacol 2006; 45: 171-6
21. Chan SSK, Cheng TY, Lin C. Relaxation effects of ligustilide and senkyunolide A, two main constituents of Ligusricum chuanxiong, in rat isolated aorta. J Ethnopharmacol 2007; 111: 677-80
22. Yan R, Ko NL Li SL, Tam YK, Lin G. Pharmacokinetics and metabolism of ligustilide, a major bioactive component in Rhizoma Chuanxiong, in the rat. Drug Metab Dispos 2007; 36: 400-8
23. Pharmacopoeia Commission of PRC. Pharmacopoeia of the People's Republic of China (Part 1). Beijing: Chemical Industry Press; 2005: Appendix X D 57
24. Nairo T. Katsuhara T, Niitsu K, Ikeya Y, Okada M, Mitsuhashi H. Two phthalides from Ligusticum chuangxiong. Phytochemistry 1992; 31: 639-42
25. Bellina F, Ciucci D, Vergamini P, Rossi R. Regioselective synthesis of natural and unnatural (Z)-3-(1-alkylidene) phthalides and 3-substituted isocoumarins starting from methyl 2-hydroxybenzoates. Tetrahedron 2000; 56: 2533-45