Membrane protected apoptotic trophoblast microparticles contain nucleic acids: Relevance to preeclampsia

American Journal of Pathology

Volumn 173, Issue 6, 2008, Pages 1595-1608

  Orozco, Aaron F ^a   Jorgez, Carolina J ^a   Horne, Cassandra ^a   Marquez Do, Deborah A ^a   Chapman, Matthew R ^a   Rodgers, John R ^a   Bischoff, Farideh Z ^b   Lewis, Dorothy E ^a,c  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b Biocept Inc   (United States)

^c University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE; DNA; ETOPOSIDE; RNA; ROTENONE;

APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DNA BINDING; EARLY DIAGNOSIS; FEMALE; FIRST TRIMESTER PREGNANCY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIGHT SCATTERING; MATERNAL PLASMA; MEMBRANE BINDING; MEMBRANE MICROPARTICLE; NUCLEIC ACID ANALYSIS; PREECLAMPSIA; PRENATAL DIAGNOSIS; PRENATAL DISORDER; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN LIPID INTERACTION; TROPHOBLAST;

EID: 57149090072     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.2353/ajpath.2008.080414     Document Type: Article

References (47)

1. Simak J, Gelderman MP: Cell Membrane Microparticles in Blood and Blood Products: potentially Pathogenic Agents and Diagnostic Markers. Transfus Med Rev 2006, 20:1-26
2. Redman CW, Sargent IL: Microparticles and Immunomodulation in Pregnancy and Pre-Eclampsia. J Reprod Immunol 2007, 76:61-67
3. Toth B, Lok CA, Boing A, Diamant M, van der Post JA, Friese K, Nieuwland R: Microparticles and Exosomes: impact on Normal and Complicated Pregnancy. Am J Reprod Immunol 2007, 58:389-402
4. Thery C, Boussac M, Veron P, Ricciardi-Castagnoli P, Raposo G, Garin J, Amigorena S: Proteomic Analysis of Dendritic Cell-Derived Exosomes: a Secreted Subcellular Compartment Distinct from Apoptotic Vesicles. J Immunol 2001, 166:7309-7318
5. Schiller M, Bekeredjian-Ding I, Heyder P, Blank N, Ho AD, Lorenz HM: Autoantigens Are Translocated into Small Apoptotic Bodies During Early Stages of Apoptosis. Cell Death Differ 2008, 15:183-191
6. Leung TN, Zhang J, Lau TK, Chan LY, Lo YM: Increased Maternal Plasma Fetal DNA Concentrations in Women Who Eventually Develop Preeclampsia. Clin Chem 2001, 47:137-139
7. Zhong XY, Holzgreve W, Hahn S: The Levels of Circulatory Cell Free Fetal DNA in Maternal Plasma Are Elevated Prior to the Onset of Preeclampsia. Hypertens Pregnancy 2002, 21:77-83
8. Swinkels DW, de Kok JB, Hendriks JC, Wiegerinck E, Zusterzeel PL, Steegers EA: Hemolysis. Elevated Liver Enzymes, and Low Platelet Count (Hellp) Syndrome as a Complication of Preeclampsia in Pregnant Women Increases the Amount of Cell-Free Fetal and Maternal DNA in Maternal Plasma and Serum Clin Chem 2002, 48:650-653
9. Bischoff FZ, Lewis DE, Simpson JL: Cell-Free Fetal DNA in Maternal Blood: kinetics. Source and Structure Hum Reprod Update 2005, 11:59-67
10. Huppertz B, Frank HG, Kingdom JC, Reister F, Kaufmann P: Villous Cytotrophoblast Regulation of the Syncytial Apoptotic Cascade in the Human Placenta. Histochem Cell Biol 1998, 110:495-508
11. Gupta AK, Holzgreve W, Huppertz B, Malek A, Schneider H, Hahn S: Detection of Fetal DNA and Rna in Placenta-Derived Syncytiotrophoblast Microparticles Generated in Vitro. Clin Chem 2004, 50:2187-2190
12. Knight M, Redman CW, Linton EA, Sargent IL: Shedding of Syncytiotrophoblast Microvilli into the Maternal Circulation in Pre-Eclamptic Pregnancies. Br J Obstet Gynaecol 1998, 105:632-640
13. Goswami D, Tannetta DS, Magee LA, Fuchisawa A, Redman CW, Sargent IL, von Dadelszen P: Excess Syncytiotrophoblast Microparticle Shedding Is a Feature of Early-Onset Pre-Eclampsia, but Not Normotensive Intrauterine Growth Restriction. Placenta 2006, 27:56-61
14. Germain SJ, Sacks GP, Sooranna SR, Sargent IL, Redman CW: Systemic Inflammatory Priming in Normal Pregnancy and Preeclampsia: the Role of Circulating Syncytiotrophoblast Microparticles. J Immunol 2007, 178:5949-5956
15. Chan KC, Zhang J, Hui AB, Wong N, Lau TK, Leung TN, Lo KW, Huang DW, Lo YM: Size Distributions of Maternal and Fetal DNA in Maternal Plasma. Clin Chem 2004, 50:88-92
16. Tjoa ML, Cindrova-Davies T, Spasic-Boskovic O, Bianchi DW, Burton GJ: Trophoblastic Oxidative Stress and the Release of Cell-Free Feto-Placental DNA. Am J Pathol 2006, 169:400-404
17. Huppertz B, Kingdom J, Caniggia I, Desoye G, Black S, Korr H, Kaufmann P: Hypoxia Favours Necrotic Versus Apoptotic Shedding of Placental Syncytiotrophoblast into the Maternal Circulation. Placenta 2003, 24:181-190
18. Kovats S, Main EK, Librach C, Stubblebine M, Fisher SJ, DeMars R: A Class I Antigen. Hla-G, Expressed in Human Trophoblasts Science 1990, 248:220-223
19. Reister F, Frank HG, Kingdom JC, Heyl W, Kaufmann P, Rath W, Huppertz B: Macrophage-Induced Apoptosis Limits Endovascular Trophoblast Invasion in the Uterine Wall of Preeclamptic Women. Lab Invest 2001, 81:1143-1152
20. James JL, Stone PR, Chamley LW: The Isolation and Characterization of a Population of Extravillous Trophoblast Progenitors from First Trimester Human Placenta. Hum Reprod 2007, 22:2111-2119
21. Chu W, Fant ME, Geraghty DE, Hunt JS: Soluble Hla-G in Human Placentas: synthesis in Trophoblasts and Interferon-Gamma-Activated Macrophages but Not Placental Fibroblasts. Hum Immunol 1998, 59:435-442
22. Al-Nasiry S, Spitz B, Hanssens M, Luyten C, Pijnenborg R: Differential Effects of Inducers of Syncytialization and Apoptosis on Bewo and Jeg-3 Choriocarcinoma Cells. Hum Reprod 2006, 21:193-201
23. Alonso MM, Asumendi A, Villar J, Gil MJ, Martinez-Merino V, Encio IJ, Migliaccio M: New Benzo(B)Thiophenesulphonamide 1,1-Dioxide Derivatives Induce a Reactive Oxygen Species-Mediated Process of Apoptosis in Tumour Cells. Oncogene 2003, 22:3759-3769
24. Montes M, Jaensson EA, Orozco AF, Lewis DE, Corry DB: A General Method for Bead-Enhanced Quantitation by Flow Cytometry. J Immunol Methods 2006, 317:45-55
25. Jorgez CJ, Dang DD, Simpson JL, Lewis DE, Bischoff FZ: Quantity Versus Quality: optimal Methods for Cell-Free DNA Isolation from Plasma of Pregnant Women. Genet Med 2006, 8:615-619
26. Darzynkiewicz Z, Galkowski D, Zhao H: Analysis of Apoptosis by Cytometry Using Tunel Assay. Methods 2008, 44:250-254
27. Heazell AE, Lacey HA, Jones CJ, Huppertz B, Baker PN, Crocker IP: Effects of Oxygen on Cell Turnover and Expression of Regulators of Apoptosis in Human Placental Trophoblast. Placenta 2008, 29:175-186
28. Crowley A, Martin C, Fitzpatrick P, Sheils O, O'Herlihy C, O'Leary JJ, Byrne BM: Free Fetal DNA Is Not Increased before 20 Weeks in Intrauterine Growth Restriction or Pre-Eclampsia. Prenat Diagn 2007, 27:174-179
29. Baby SM, Roy A, Lahiri S: Role of Mitochondria in the Regulation of Hypoxia-Inducible Factor-1α in the Rat Carotid Body Glomus Cells. Histochem Cell Biol 2005, 124:69-76
30. Wang P, Song JH, Song DK, Zhang J, Hao C: Role of Death Receptor and Mitochondrial Pathways in Conventional Chemotherapy Drug Induction of Apoptosis. Cell Signal 2006, 18:1528-1535
31. Wolbers F, Buijtenhuijs P, Haanen C, Vermes I: Apoptotic Cell Death Kinetics in Vitro Depend on the Cell Types and the Inducers Used. Apoptosis 2004, 9:385-392
32. Gonzalez-Quintero VH, Jimenez JJ, Jy W, Mauro LM, Hortman L, O'Sullivan MJ, Ahn Y: Elevated Plasma Endothelial Microparticles in Preeclampsia. Am J Obstet Gynecol 2003, 189:589-593
33. Tatischeff I, Lavialle F, Pigaglio-Deshayes S, Péchoux-Longin C, Chinsky L, Alfsen A: Dictyostelium Extracellular Vesicles Containing Hoechst 33342 Transfer the Dye into the Nuclei of Living Cells: A Fluorescence Study. J Fluoresc 2007,
34. Pohl FM, Thomae R, Karst A: Temperature Dependence of the Activity of DNA-Modifying Enzymes: endonucleases and DNA Ligase. Eur J Biochem 1982, 123:141-152
35. Lo YM, Tsui NB, Chiu RW, Lau TK, Leung TN, Heung MM, Gerovassili A, Jin Y, Nicolaides KH, Cantor CR, Ding C: Plasma Placental Rna Allelic Ratio Permits Noninvasive Prenatal Chromosomal Aneuploidy Detection. Nat Med 2007, 13:218-223
36. Ng EK, Tsui NB, Lam NY, Chiu RW, Yu SC, Wong SC, Lo ES, Rainer TH, Johnson PJ, Lo YM: Presence of Filterable and Nonfilterable Mrna in the Plasma of Cancer Patients and Healthy Individuals. Clin Chem 2002, 48:1212-1217
37. Maron JL, Bianchi DW: Prenatal Diagnosis Using Cell-Free Nucleic Acids in Maternal Body Fluids: a Decade of Progress. Am J Med Genet C Semin Med Genet 2007, 145:5-17
38. Lo YM, Leung TN, Tein MS, Sargent IL, Zhang J, Lau TK, Haines CJ, Redman CW: Quantitative Abnormalities of Fetal DNA in Maternal Serum in Preeclampsia. Clin Chem 1999, 45:184-188
39. Formigli L, Zecchi Orlandini S, Capaccioli S, Poupon MF, Bani D: Energy-Dependent Types of Cell Death in Mcf-7 Breast Cancer Cell Tumors Implanted into Nude Mice. Cells Tissues Organs 2002, 170:99-110
40. Formigli L, Papucci L, Tani A, Schiavone N, Tempestini A, Orlandini GE, Capaccioli S, Orlandini SZ: Aponecrosis: morphological and Biochemical Exploration of a Syncretic Process of Cell Death Sharing Apoptosis and Necrosis. J Cell Physiol 2000, 182:41-49
41. Papucci L, Formigli L, Schiavone N, Tani A, Donnini M, Lapucci A, Perna F, Tempestini A, Witort E, Morganti M, Nosi D, Orlandini GE, Zecchi Orlandini S, Capaccioli S: Apoptosis Shifts to Necrosis Via Intermediate Types of Cell Death by a Mechanism Depending on C-Myc and Bcl-2 Expression. Cell Tissue Res 2004, 316:197-209
42. Li Y, Zimmermann B, Rusterholz C, Kang A, Holzgreve W, Hahn S: Size Separation of Circulatory DNA in Maternal Plasma Permits Ready Detection of Fetal DNA Polymorphisms. Clin Chem 2004, 50:1002-1011
43. Gupta AK, Holzgreve W, Hahn S: Decrease in Lipid Levels of Syncytiotrophoblast Micro-Particles Reduced Their Potential to Inhibit Endothelial Cell Proliferation. Arch Gynecol Obstet 2008, 277:115-119
44. Jorgez CJ, Simpson JL, Bischoff FZ: Recovery and Amplification of Placental Rna from Dried Maternal Blood Spots: utility for Non-Invasive Prenatal Diagnosis. Reprod Biomed Online 2006, 13:558-561
45. Sekizawa A, Farina A, Sugito Y, Matsuoka R, Iwasaki M, Saito H, Okai T: Proteinuria and Hypertension Are Independent Factors Affecting Fetal DNA Values: a Retrospective Analysis of Affected and Unaffected Patients. Clin Chem 2004, 50:221-224
46. Farina A, Sekizawa A, Iwasaki M, Matsuoka R, Ichizuka K, Okai T: Total Cell-Free DNA (Beta-Globin Gene) Distribution in Maternal Plasma at the Second Trimester: a New Prospective for Preeclampsia Screening. Prenat Diagn 2004, 24:722-726
47. Banzola I, Farina A, Concu M, Sekizawa A, Purwosunu Y, Strada I, Arcelli D, Simonazzi G, Caramelli E, Rizzo N: Performance of a Panel of Maternal Serum Markers in Predicting Preeclampsia at 11-15 Weeks' Gestation. Prenat Diagn 2007, 27:1005-1010