Impact of fibrinogen concentration in severely ill patients on mechanical properties of whole blood clots

Blood Coagulation and Fibrinolysis

Volumn 19, Issue 8, 2008, Pages 765-770

  Dempfle, Carl Erik ^a   Kälsch, Thorsten ^a   Elmas, Elif ^a   Suvajac, Nenad ^a   Lücke, Thomas ^a   Münch, Elke ^a   Borggrefe, Martin ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Clot elastic modulus; Fibrin; Fibrinogen; Hemodyne; Platelet contractile force

Indexed keywords

FIBRINOGEN; THROMBOPLASTIN;

ARTICLE; BLOOD CLOTTING; BLOOD SAMPLING; CONTROLLED STUDY; HOMEOSTASIS; HOSPITAL ADMISSION; HUMAN; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; THROMBIN TIME; THROMBOCYTE COUNT; YOUNG MODULUS;

BIOMECHANICS; BLOOD COAGULATION; BLOOD COAGULATION TESTS; BLOOD PLATELETS; CRITICAL ILLNESS; ELASTIC MODULUS; FIBRINOGEN; HEMOSTASIS; HUMANS; PLATELET COUNT;

EID: 57149084514     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/MBC.0b013e32830f1b68     Document Type: Article

References (19)

1. Stephan F, Hollande J, Richard O, Cheffi A, Maier-Redelsperger M, Flahault A. Thrombocytopenia in a surgical ICU. Chest 1999; 115:1363-1370.
2. Hiippala ST, Myllyla GJ, Vahtera EM. Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates. Anesth Analg 1995; 81:360-365.
3. Martinowitz U, Michaelson M. Guidelines for the use of recombinant activated factor VII (rFVIIa) in uncontrolled bleeding: a report by the Israeli Multidisciplinary rFVIIa Task Force. J Thromb Haemost 2005; 3:640-648.
4. Vincent JL, Rossaint R, Riou B, Ozier Y, Zideman D, Spahn DR. Recommendations on the use of recombinant activated factor VII as an adjunctive treatment for massive bleeding - a European perspective. Crit Care 2006; 10:R120.
5. Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost 2001; 86:1327-1330.
6. Carr ME Jr. Measurement of platelet force: the Hemodyne hemostasis analyzer. Clin Lab Manage Rev 1995; 9:312-314; 316-318, 320.
7. Carr ME Jr. Development of platelet contractile force as a research and clinical measure of platelet function. Cell Biochem Biophys 2003; 38:55-78.
8. Clauss A. Rapid physiological coagulation method in determination of fibrinogen. Acta Haematol 1957; 17:237-246.
9. Carr ME Jr, Martin EJ, Carr SL. Delayed, reduced or inhibited thrombin production reduces platelet contractile force and results in weaker clot formation. Blood Coagul Fibrinolysis 2002; 13:193-197.
10. Hartert H. Thrombelastography, a method for physical analysis of blood coagulation. Z Gesamte Exp Med 1951; 117:189-203.
11. Essell JH, Martin TJ, Salinas J, Thompson JM, Smith VC. Comparison of thromboelastography to bleeding time and standard coagulation tests in patients after cardiopulmonary bypass. J Cardiothorac Vasc Anesth 1993; 7:410-415.
12. Welsby IJ, Jiao K, Ortel TL, Brudney CS, Roche AM, Bennett-Guerrero E, Gan TJ. The kaolin-activated thrombelastograph predicts bleeding after cardiac surgery. J Cardiothorac Vasc Anesth 2006; 20:531-535.
13. Nielsen VG, Cohen BM, Cohen E. Effects of coagulation factor deficiency on plasma coagulation kinetics determined via thrombelastography: critical roles of fibrinogen and factors II, VII, X and XII. Acta Anaesthesiol Scand 2005; 49:222-231.
14. Fries D, Innerhofer P, Reif C, Streif W, Klingler A, Schobersberger W, et al. The effect of fibrinogen substitution on reversal of dilutional coagulopathy: an in vitro model. Anesth Analg 2006; 102:347-351.
15. Collins PW, Macchiavello LI, Lewis SJ, Macartney NJ, Saayman AG. Luddington R, et al. Global tests of haemostasis in critically ill patients with severe sepsis syndrome compared to controls. Br J Haematol 2006; 135:220-227.
16. Coakley M, Reddy K, Mackie I, Mallett S. Transfusion triggers in orthotopic liver transplantation: a comparison of the thromboelastometry analyzer, the thromboelastogram, and conventional coagulation tests. J Cardiothorac Vasc Anesth 2006; 20:548-553.
17. D'Amico EA, Chamone DA, Bydlowski SP. In vitro effects of rt-PA on platelet function and clot strength. Thromb Res 1997; 85:519-522.
18. Fenger-Eriksen C, Anker-Moller E, Heslop J, Ingerslev J, Sorensen B. Thrombelastographic whole blood clot formation after ex vivo addition of plasma substitutes: improvements of the induced coagulopathy with fibrinogen concentrate. Br J Anaesth 2005; 94:324-329.
19. Spalding GJ, Hartrumpf M, Sierig T, Oesberg N, Kirschke CG, Albes JM. Cost reduction of perioperative coagulation management in cardiac surgery: value of "bedside" thrombelastography (ROTEM). Eur J Cardiothorac Surg 2007; 31:1052-1057.