In vitro effects of rt-Pa on platelet function and clot strength

Thrombosis Research

Volumn 85, Issue 6, 1997, Pages 519-522

  D'Amico, Elbio A ^a,b   Chamone, Dalton A F ^a   Bydlowski, Sérgio P ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b NONE   (Italy)

Author keywords

clot strength; fibrinogen; platelets; recombinant tissue type plasminogen activator; thromboelastography; thrombolysis

Indexed keywords

ALTEPLASE;

ARTICLE; BLOOD CLOT; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; NORMAL HUMAN; PRIORITY JOURNAL; THROMBOCYTE FUNCTION;

ADENOSINE DIPHOSPHATE; BLOOD COAGULATION; BLOOD PLATELETS; COLLAGEN; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; FIBRINOGEN; HUMANS; PLASMINOGEN; PLATELET AGGREGATION; RECOMBINANT PROTEINS; THROMBELASTOGRAPHY; TISSUE PLASMINOGEN ACTIVATOR;

EID: 0030915604     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(97)00041-8     Document Type: Article

References (8)

1. MARDER, V.J., HIRSH, J. and BELL, W.R. Rationale and practical basis of thrombolytic therapy. In: Hemostasis and Thrombosis: Basic Principles and Clinical Practice. R.W. Colman, J. Hirsh, V.J. Marder and E.W. Salzman.(eds.),pp. 1514-1541, J.B. Lippincott, Philadelphia (1994).
2. OWEN, J., FRIEDMAN, K.D., GROSSMAN, B.A., WILKINS, C., BERKE, A.D. and POWERS, E.R. Quantitation of fragment X during thrombolityc therapy with strepkinase and tissue plasminogen activator. J Clin Invest 79, 1642-1647, 1987.
3. BERDGE, D.C., MAKIN, G.S. and HOPKINSON, B.R. Local low dose intra-arterial thrombolytic therapy: the risk of stroke or major haemorrhage. Br J Surg 76, 1230-1233, 1989.
4. CHIGNARD, M.., LE COUEDIC, J.P., TENCE, M., VARGAFTIG, B.B. and BENVENISTE, J. The role of platelet-activating factor in platelet aggregation. Nature 279, 799-800, 1979.
5. BOWIE, E.J.W., THOMPSON, J.H., DIDISHEIM, P. and OWEN, C.A. Laboratory manual of hemostasis. Saunders, Philadelphia, 1971.p.75.
6. ALKJAERSIG, N., FLETCHER, A.P. and SHERRY, S. The mechanism of clot dissolution by plasmin. J Clin Invest 38, 1086-1095, 1959.
7. MERSKEY, C., LALEZARY, P. and JOHNSON, A.J. A rapid, simple, sensitive method for measuring fibrinolytic split products in human serum. Proceedings Soc Exp Biol 131, 871-875, 1969.
8. TRAVERSO, C.I., CAPRINI, J.A. and ARCELUS, J.I. The normal thromboelastogram and its interpretation. Semin Thromb Hemost 21 (Suppl.4), 7-13, 1995.