p53 labeling index in assessing the efficacy of a sunscreen in protection against UV-induced damage

International Journal of Dermatology

Volumn 47, Issue 12, 2008, Pages 1234-1239

  Lens, Marko ^a,b,c   Bielfeldt, S ^a,b,c   Bataille, Veronique ^a,b,c   Wilhelm, K P ^a,b,c  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b Institute for Applied Dermatological Research   (Germany)

^c WEST HERTFORDSHIRE HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; SUNSCREEN;

ADULT; ARTICLE; CLINICAL ARTICLE; DNA DAMAGE; DRUG EFFICACY; EPIDERMIS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LABELING INDEX; MALE; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RADIATION INJURY; RADIATION PROTECTION; SENSITIVITY ANALYSIS; SKIN CARCINOGENESIS; SKIN DEFECT; ULTRAVIOLET IRRADIATION; ULTRAVIOLET RADIATION;

ADULT; DNA DAMAGE; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; SKIN; SUNSCREENING AGENTS; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 57049188971     PISSN: 00119059     EISSN: 13654632     Source Type: Journal    
DOI: 10.1111/j.1365-4632.2008.03785.x     Document Type: Article

References (33)

1. Soehnge H, Ouhtit A, Ananthaswamy ON. Mechanisms of induction of skin cancer by UV radiation. Front Biosci 1997; 2: D538-d551.
2. De Gruijl FR, Van Kranen HJ, Mullenders LH. UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer. J Photochem Photobiol B: Biol 2001; 63: 19-27.
3. Latonen L, Laiho M. Cellular UV damage responses - functions of tumor suppressor p53. Biochim Biophys Acta 2005; 1755: 71-89.
4. Ziegler A, Jonason AS, Leffell DJ, et al. Sunburn and p53 in the onset of skin cancer. Nature 1994; 372: 773-776.
5. Hall PA, McKee PH, Menage HD, et al. High levels of p53 protein in UV-irradiated normal human skin. Oncogene 1993; 8: 203-207.
6. Hall PA, Lane DP. Tumour suppressors - a developing role for p53? Curr Biol 1997; 7: R144-R147.
7. Vousden KH, Lu X. Live or let die: The cell's response to p53. Nat Rev Cancer 2002; 2: 594-604.
8. Moyal D, Chardon A, Kollias N. UVA protection efficacy of sunscreens can be determined by the persistent pigment darkening (PPD) method (Part 2). Photodermatol Photoimmunol Photomed 2000; 16: 250-255.
9. Young AR. Methods used to evaluate the immune protection factor of a sunscreen: Advantages and disadvantages of different in vivo techniques. Cutis 2004; 74(5 Suppl.): 19-23.
10. Fourtanier A, Moyal D, Maccario J, et al. Measurement of sunscreen immune protection factors in humans: A consensus paper. J Invest Dermatol 2005; 125: 403-409.
11. Ponten F, Berne B, Ren ZP, et al. Ultraviolet light induces expression of p53 and p21 in human skin: Effect of sunscreen and constitutive p21 expression in skin appendages. J Invest Dermatol 1995; 105: 402-406.
12. Seite S, Moyal D, Verdier MP, et al. Accumulated p53 protein and UVA protection level of sunscreens. Photodermatol Photoimmunol Photomed 2000; 16: 3-9.
13. Marrot L, Belaidi JP, Meunier JR. Comet assay combined with p53 detection as a sensitive approach for DNA photoprotection assessment in vitro. Exp Dermatol 2002; 11(Suppl. 1): 33-36.
14. Liardet S, Scaletta C, Panizzon R, et al. Protection against pyrimidine dimers, p53, and 8-hydroxy-2′-deoxyguanosine expression in ultraviolet-irradiated human skin by sunscreens: Difference between UVB + UVA and UVB alone sunscreens. J Invest Dermatol 2001; 117: 1437-1441.
15. Kielbassa C, Roza L, Epe B. DNA damage by UV and visible light and its wavelength dependence. Methods Enzymol 2000; 319: 436-445.
16. Murphy M, Mabruk MJ, Lenane P, et al. The expression of p53, 21, Bax and induction of apoptosis in normal volunteers in response to different doses of ultraviolet radiation. Br J Dermatol 2002; 147: 110-117.
17. Lane D. Awakening angels. Nature 1998; 394: 616-617.
18. Campbell C, Quinn AG, Angus B, et al. Wavelength specific patterns of p53 induction in human skin following exposure to UV radiation. Cancer Res 1993; 53: 2697-2699.
19. Kapoor M, Hamm R, Yan W, et al. Cooperative phosphorylation at multiple sites is required to activate p53 in response to UV radiation. Oncogene 2000; 19: 358-364.
20. She QB, Chen N, Dong Z. ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation. J Biol Chem 2000; 275: 20, 444-20, 449.
21. Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature 2000; 408: 307-310.
22. Ananthaswamy HN, Loughlin SM, Cox P, et al. Sunlight and skin cancer: inhibition of p53 mutations in UV-irradiated mouse skin by sunscreens. Nat Med 1997; 3: 510-514.
23. Sablina AA, Budanov AV, Ilyinskaya GV, et al. The antioxidant function of the p53 tumor suppressor. Nat Med 2005; 11: 1306-1313.
24. Cui R, Widlund HR, Feige E, et al. Central role of p53 in the suntan response and pathologic hyperpigmentation. Cell 2007; 128: 853-864.
25. Bykov VJ, Marcusson JA, Hemminki K. Ultraviolet B-induced DNA damage in human skin and its modulation by a sunscreen. Cancer Res 1998; 58: 2961-2964.
26. Ley RD, Fourtanier A. Sunscreen protection against ultraviolet radiation-induced pyrimidine dimers in mouse epidermal DNA. Photochem Photobiol 1997; 65: 1007-1011.
27. van Praag MC, Roza L, Boom BW, et al. Determination of the photoprotective efficacy of a topical sunscreen against UVB-induced DNA damage in human epidermis. J Photochem Photobiol B: Biol 1993; 19: 129-134.
28. Freeman SE, Ley RD, Ley KD. Sunscreen protection against UV-induced pyrimidine dimers in DNA of human skin in situ. Photodermatology 1988; 5: 243-247.
29. Berne B, Ponten J, Ponten F. Decreased p53 expression in chronically sun-exposed human skin after topical photoprotection. Photodermatol Photoimmunol Photomed 1998; 14: 148-153.
30. Stern RS, Weinstein MC, Baker SG. Risk reduction of nonmelanoma skin cancer with childhood sunscreen use. Arch Dermatol 1986; 122: 537-545.
31. Marrot L, Belaidi JP, Lejeune F, et al. Photostability of sunscreen products influences the efficiency of protection with regard to UV-induced genotoxic or photoageing-related endpoints. Br J Dermatol 2004; 151: 1235-1244.
32. Fourtanier A, Bernerd F, Bouillon C, et al. Protection of skin biological targets by different types of sunscreens. Photodermatol Photoimmunol Photomed 2006; 22: 22-32.
33. Seite S, Medaisko C, Christiaens F et al. Biological effects of simulated ultraviolet daylight: A new approach to investigate daily photoprotection. Photodermatol Photoimmunol Photomed 2006; 22: 67-77.