Establishment and quantitative imaging of a 3D lung organotypic model of mammary tumor outgrowth

Clinical and Experimental Metastasis

Volumn 25, Issue 8, 2008, Pages 877-885

  Martin, Michelle D ^a   Fingleton, Barbara ^a   Lynch, Conor C ^a,b   Wells, Sam ^a   McIntyre, J Oliver ^a   Piston, David W ^a   Matrisian, Lynn M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

Breast cancer; Host tumor interactions; Metastasis; Microenvironment; Organotypic co culture

Indexed keywords

GREEN FLUORESCENT PROTEIN; VIRUS MIDDLE T ANTIGEN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BREAST TUMOR; CELL LABELING; CELL PROLIFERATION; COCULTURE; CONFOCAL MICROSCOPY; FLOW CYTOMETRY; IMAGING SYSTEM; LUNG METASTASIS; LUNG MODEL; MOUSE; NONHUMAN; POLYOMA VIRUS;

ANIMALS; COCULTURE TECHNIQUES; DIAGNOSTIC IMAGING; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; FLOW CYTOMETRY; GREEN FLUORESCENT PROTEINS; IMAGING, THREE-DIMENSIONAL; IMMUNOENZYME TECHNIQUES; LUNG NEOPLASMS; MAMMARY NEOPLASMS, EXPERIMENTAL; MAMMARY TUMOR VIRUS, MOUSE; MICE; MICE, INBRED C57BL; MICE, NUDE; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; ORGAN CULTURE TECHNIQUES; TUMOR CELLS, CULTURED;

EID: 57049187266     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/s10585-008-9206-y     Document Type: Article

References (21)

1. S Hiratsuka K Nakamura S Iwai 2002 MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis Cancer Cell 2 4 289 300 10.1016/S1535-6108(02)00153-8
2. T Itoh M Tanioka H Matsuda 1999 Experimental metastasis is suppressed in MMP-9-deficient mice Clin Exp Metastasis 17 2 177 181 10.1023/A:1006603723759
3. A Muller B Homey H Soto 2001 Involvement of chemokine receptors in breast cancer metastasis Nature 410 6824 50 56 10.1038/35065016
4. GP Gupta DX Nguyen AC Chiang 2007 Mediators of vascular remodelling co-opted for sequential steps in lung metastasis Nature 446 7137 765 770 10.1038/nature05760
5. J Debnath KR Mills NL Collins 2002 The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini Cell 111 1 29 40 10.1016/S0092-8674(02)01001-2
6. CH Streuli MJ Bissell 1990 Expression of extracellular matrix components is regulated by substratum J Cell Biol 110 1405 1415 10.1083/jcb.110.4.1405
7. J Debnath SK Muthuswamy JS Brugge 2003 Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures Methods 30 3 256 268 10.1016/S1046-2023(03)00032-X
8. JB Kim 2005 Three-dimensional tissue culture models in cancer biology Semin Cancer Biol 15 5 365 377 10.1016/j.semcancer.2005.05.002
9. JB Kim R Stein MJ O'Hare 2004 Three-dimensional in vitro tissue culture models of breast cancer-a review Breast Cancer Res Treat 85 3 281 291 10.1023/B:BREA.0000025418.88785.2b
10. Martin MD et al (2008) Effect of ablation or inhibition of stromal matrix metalloproteinase-9 lung metastasis in a breast cancer model is dependent on genetic background. Cancer Res 68:6251-6259
11. CT Guy RD Cardiff WJ Muller 1992 Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease Mol Cell Biol 12 3 954 961
12. M Liu SJ Skinner J Xu 1992 Stimulation of fetal rat lung cell proliferation in vitro by mechanical stretch Am J Physiol 263 3 Pt 1 L376 L383
13. LL Simpson AK Tanswell MG Joneja 1985 Epithelial cell differentiation in organotypic cultures of fetal rat lung Am J Anat 172 1 31 40 10.1002/aja.1001720103
14. E Mourgeon N Isowa S Keshavjee 2000 Mechanical stretch stimulates macrophage inflammatory protein-2 secretion from fetal rat lung cells Am J Physiol Lung Cell Mol Physiol 279 4 L699 L706
15. AK Sasser BL Mundy KM Smith 2007 Human bone marrow stromal cells enhance breast cancer cell growth rates in a cell line-dependent manner when evaluated in 3D tumor environments Cancer Lett 254 2 255 264 10.1016/j.canlet.2007.03.012
16. MJ Bissell D Radisky 2001 Putting tumours in context Nat Rev Cancer 1 46 54
17. JL Becker DK Blanchard 2007 Characterization of primary breast carcinomas grown in three-dimensional cultures J Surg Res 142 2 256 262 10.1016/j.jss.2007.03.016
18. V Novaro CD Roskelley MJ Bissell 2003 Collagen-IV and laminin-1 regulate estrogen receptor alpha expression and function in mouse mammary epithelial cells J Cell Sci 116 Pt 14 2975 2986 10.1242/jcs.00523
19. GY Lee PA Kenny EH Lee 2007 Three-dimensional culture models of normal and malignant breast epithelial cells Nat Methods 4 4 359 365 10.1038/nmeth1015
20. T Ohmori JL Yang JO Price 1998 Blockade of tumor cell transforming growth factor-betas enhances cell cycle progression and sensitizes human breast carcinoma cells to cytotoxic chemotherapy Exp Cell Res 245 2 350 359 10.1006/excr.1998.4261
21. AA Luck AJ Evans AR Green 2008 The influence of basal phenotype on the metastatic pattern of breast cancer Clin Oncol (R Coll Radiol) 20 1 40 45 10.1016/j.clon.2007.10.002