Correlations of human herpesvirus 6B and CMV infection with acute GVHD in recipients of allogeneic haematopoietic stem cell transplantation

Bone Marrow Transplantation

Volumn 42, Issue 10, 2008, Pages 673-677

  Wang, L R ^a   Dong, L J ^b   Zhang, M J ^c   Lu, D P ^a,b  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^b Beijing Daopei Hospital   (China)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; BUSULFAN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; GANCICLOVIR; MEPREDNISONE; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TACROLIMUS; THYMOCYTE ANTIBODY;

ACUTE GRAFT VERSUS HOST DISEASE; ACUTE LEUKEMIA; ADOLESCENT; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANTIGENICITY; APLASTIC ANEMIA; ARTICLE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOMEGALOVIRUS INFECTION; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE COURSE; FEMALE; GRAFT REJECTION; HERPES VIRUS INFECTION; HUMAN; HUMAN HERPESVIRUS 6; IMMUNOSUPPRESSIVE TREATMENT; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MULTIPLE MYELOMA; MYELODYSPLASTIC SYNDROME; NONHODGKIN LYMPHOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK ASSESSMENT; SCHOOL CHILD; VIRUS REACTIVATION;

ACUTE DISEASE; ADOLESCENT; ADULT; CHILD; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; FEMALE; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HERPESVIRUS 6, HUMAN; HUMANS; INCIDENCE; MALE; MIDDLE AGED; RISK; ROSEOLOVIRUS INFECTIONS; TRANSPLANTATION, HOMOLOGOUS; VIRUS ACTIVATION; YOUNG ADULT;

EID: 57049155446     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/bmt.2008.238     Document Type: Article

References (23)

1. Goker H, Haznedaroglu IC, Chao NJ. Acute graft-vs-host disease: pathobiology and management. Exp Hematol 2001; 29: 259-277.
2. Gray C, Levy RB. The ability of murine cytomegalovirus and class I major histocompatibility complex-disparate parental cells to induce alterations characteristic of severe graft-versus-host reactions. Transplantation 1989; 48: 1057-1063.
3. Miller W, Flynn P, McCullough J, Balfour Jr HH, Goldman A, Haake R et al. Cytomegalovirus infection after bone marrow transplantation: An association with acute graft-v-host disease. Blood 1986; 67: 1162-1167.
4. Volin L, Lautenschlager I, Juvonen E, Nihtinen A, Anttila VJ, Ruutu T. Human herpesvirus 6 antigenaemia in allogeneic stem cell transplant recipients: Impact on clinical course and association with other beta-herpesviruses. Br J Haematol 2004; 126: 690-696.
5. Tomonari A, Takahashi S, Ooi J, Iseki T, Takasugi K, Uchiyama M et al Human herpesvirus 6 variant B infection in adult patients after unrelated cord blood transplantation. Int J Hematol 2005; 81 352-355.
6. Ljungman P, Wang FZ, Clark DA, Emery VC, Remberger M, Ringden O et al High levels of human herpesvirus 6 DNA in peripheral blood leucocytes are correlated to platelet engraftment and disease in allogeneic stem cell transplant patients. Br J Haematol 2000; 111: 774-781.
7. Chan PK, Peiris JS, Yuen KY, Liang RH, Lau YL, Chen FE et al. Human herpesvirus-6 and human herpesvirus-7 infections in bone marrow transplant recipients. J Med Virol 1997; 53: 295-305.
8. Lu DP, Dong L, Wu T, Huang XJ, Zhang MJ, Chen H et al. Conditioning including antithymocyte globulin followed by un-manipulated HLA-mismatched/haploidentical blood and marrow transplantation can achieve comparable outcomes to HLA-identical sibling transplantation. Blood 2006; 107: 3065-3073.
9. Zerr DM, Gooley TA, Yeung L, Huang ML, Carpenter P, Wade JC et al. Human herpesvirus 6 reactivation and encephalitis in allogeneic bone marrow transplant recipients. Clin Infect Dis 2001; 33: 763-771.
10. Yasunaga Ji, Sakai T, Nosaka K, Etoh Ki, Tamiya S, Koga S et al. Impaired production of naive T lymphocytes in human T-cell leukemia virus type I-infected individuals: Its implications in the immunodeficient state. Blood 2001; 97: 3177-3183.
11. Wang LR, Dong LJ, Lu DP. Surveillance of active human herpesvirus 6 infection in Chinese recipients of hematopoietic stem cell transplantation with 3 different methods. Int J Hematol 2006; 84: 262-267.
12. Deeg HJ, Storb R. Graft-versus-host disease: Pathophysiological and clinical aspects. Annu Rev Med 1984; 35: 11-24.
13. Thomas ED, Storb R, Clift RA, Fefer A, Johnson L, Neiman PE et al. Bone marrow transplantation. New Engl J Med 1975; 292: 832-843, -895-902.
14. Gerna G, Lilleri D, Baldanti F, Torsellini M, Giorgiani G, Zecca M et al. Human cytomegalovirus immediate-early mRNAemia versus pp65 antigenemia for guiding pre-emptive therapy in children and young adults undergoing haematopoietic stem cell transplantation: A prospective, randomized, open-label trial. Blood 2003; 101: 5053-5060.
15. Wang LR, Dong LJ, Zhang MJ, Lu DP. The impact of human herpesvirus 6B reactivation on early complications following allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2006; 12: 1031-1037.
16. Yoshikawa T, Ihira M, Ohashi M, Suga S, Asano Y, Miyazaki H et al. Correlation between HHV-6 infection and skin rash after allogeneic bone marrow transplantation. Bone Marrow Transplant 2001; 28: 77-81.
17. Yoshikawa T, Goshima F, Akimoto S, Ozaki T, Iwasaki T, Kurata T et al Human herpesvirus 6 infection of human epidermal cell line: pathogenesis of skin manifestations. J Med Virol 2003; 71: 62-68.
18. Inoue Y, Yasukawa M, Fujita S. Induction of T-cell apoptosis by human herpesvirus 6. J Virol 1997; 71: 3751-3759.
19. Flamand L, Gosselin J, Stefanescu I, Ablashi D, Menezes J. Immunosuppressive effect of human herpesvirus 6 on T-cell functions: suppression of interleukin-2 synthesis and cell proliferation. Blood 1995; 85: 1263-1271.
20. Appleton AL, Sviland L. Pathogenesis of GVHD: Role of herpes viruses. Bone Marrow Transplant 1993; 11: 349-355.
21. Lautenschlager I, Harma M, Hockerstedt K, Linnavuori K, Loginov R, Taskinen E. Human herpesvirus-6 infection is associated with adhesion molecule induction and lymphocyte infiltration in liver allografts. J Hepatol 2002; 37: 648-654.
22. Flamand L, Gosselin J, D'Addario M, Hiscott J, Ablashi DV, Gallo RC et al. Human herpesvirus 6 induces interleukin-1 beta and tumor necrosis factor alpha, but not interleukin-6, in peripheral blood mononuclear cell cultures. J Virol 1991; 65: 5105-5110.
23. Grivel JC, Santoro F, Chen S, Faga G, Malnati MS, Ito Y et al. Pathogenic effects of human herpesvirus 6 in human lymphoid tissue ex vivo. J Virol 2003; 77: 8280-8289.