ABCG2 is expressed in late spermatogenesis and is associated with the acrosome

Biochemical and Biophysical Research Communications

Volumn 378, Issue 2, 2009, Pages 302-307

  Scharenberg, Christian ^a,b   Mannowetz, Nadja ^a   Robey, Robert W ^c   Brendel, Cornelia ^b   Repges, Philip ^a   Sahrhage, Tim ^a   Jähn, Thomas ^a   Wennemuth, Gunther ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

ABCG2; Acrosome; Cholesterol efflux; Spermatozoa

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; CHOLESTEROL; HOE 33342;

ACROSOME; ANIMAL CELL; ARTICLE; BULL (BOVINE); CELL ISOLATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; SEMEN ANALYSIS; SPERMATOGENESIS; SPERMATOZOON; STAINING; STEM CELL; SWISS WEBSTER MOUSE;

ACROSOME; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CATTLE; CELL MEMBRANE; CHOLESTEROL; HUMANS; INDOLES; MALE; MICE; MICE, INBRED C57BL; RATS; SPERMATOGENESIS; TESTIS;

MUS; RATTUS;

EID: 57049115382     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.11.058     Document Type: Article

References (24)

1. Chang M.C. Fertilizing capacity of spermatozoa deposited into the fallopian tubes. Nature 168 (1951) 697-698
2. Austin C.R. The capacitation of the mammalian sperm. Nature 170 (1952) 326
3. Visconti P.E., Bailey J.L., Moore G.D., Pan D., Olds-Clarke P., and Kopf G.S. Capacitation of mouse spermatozoa. I. Correlation between the capacitation state and protein tyrosine phosphorylation. Development 121 (1995) 1129-1137
4. Yanagimachi R. Mammalian fertilization. In: Knobil E., and Neill J.D. (Eds). The Physiology of Reproduction (1994) 189-317
5. van Gestel R., Brewis I., Ashton P., Helms J., Brouwers J., and Gadella B. Capacitation-dependent concentration of lipid rafts in the apical ridge head area of porcine sperm cells. Mol. Hum. Reprod. 11 (2005) 583-590
6. Morales C.R., Marat A.L., Ni X., Yu Y., Oko R., Smith B.T., and Argraves W.S. ATP-binding cassette transporters ABCA1, ABCA7, and ABCG1 in mouse spermatozoa. Biochem. Biophys. Res. Commun. 376 (2008) 472-477
7. Robey R., Polgar O., Deeken J., To K., and Bates S. ABCG2: determining its relevance in clinical drug resistance. Cancer Metastasis Rev. 26 (2007) 39-57
8. Krishnamurthy P., and Schuetz J.D. Role of ABCG2/BCRP in biology and medicine. Annu. Rev. Pharmacol. Toxicol. 46 (2006) 381-410
9. Scharenberg C., Harkey M., and Torok-Storb B. The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors. Blood 99 (2002) 507-512
10. Fetsch P.A., Abati A., Litman T., Morisaki K., Honjo Y., Mittal K., and Bates S.E. Localization of the ABCG2 mitoxantrone resistance-associated protein in normal tissues. Cancer Lett. 235 (2006) 84-92
11. Lassalle B., Bastos H., Louis J.P., Riou L., Testart J., Dutrillaux B., Fouchet P., and Allemand I. 'Side Population' cells in adult mouse testis express Bcrp1 gene and are enriched in spermatogonia and germinal stem cells. Development 131 (2004) 479-487
12. Litman T., Jensen U., Hansen A., Covitz K.M., Zhan Z., Fetsch P., Abati A., Hansen P.R., Horn T., Skovsgaard T., and Bates S.E. Use of peptide antibodies to probe for the mitoxantrone resistance-associated protein MXR/BCRP/ABCP/ABCG2. Biochim. Biophys. Acta 1565 (2002) 6-16
13. Robey R.W., Honjo Y., Morisaki K., Nadjem T.A., Runge S., Risbood M., Poruchynsky M.S., and Bates S.E. Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity. Br. J. Cancer 89 (2003) 1971-1978
14. Wennemuth G., Westenbroek R., Xu T., Hille B., and Babcock D. CaV2.2 and CaV2.3 (N- and R-type) Ca2+ channels in depolarization-evoked entry of Ca2+ into mouse sperm. J. Biol. Chem. 275 (2000) 21210-21217
15. Wennemuth G., Carlson A.E., Harper A.J., and Babcock D.F. Bicarbonate actions on flagellar and Ca2+-channel responses: initial events in sperm activation. Development 130 (2003) 1317-1326
16. Vincent S., Segretain D., Nishikawa S., Nishikawa S.I., Sage J., Cuzin F., and Rassoulzadegan M. Stage-specific expression of the Kit receptor and its ligand (KL) during male gametogenesis in the mouse: a Kit-KL interaction critical for meiosis. Development 125 (1998) 4585-4593
17. Bligh E.G., and Dyer W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37 (1959) 911-917
18. Dittmer J.C., and Lester R.L. A simple, specific spray for the detection of phospholipids on thin-layer chromatograms. J. Lipid Res. 15 (1964) 126-127
19. Foulkes N.S., Schlotter F., Pevet P., and Sassone-Corsi P. Pituitary hormone FSH directs the CREM functional switch during spermatogenesis. Nature 362 (1993) 264-267
20. Ren D., Navarro B., Perez G., Jackson A.C., Hsu S., Shi Q., Tilly J.L., and Clapham D.E. A sperm ion channel required for sperm motility and male fertility. Nature 413 (2001) 603-609
21. Flesch F., Brouwers J., Nievelstein P., Verkleij A., van Golde L., Colenbrander B., and Gadella B. Bicarbonate stimulated phospholipid scrambling induces cholesterol redistribution and enables cholesterol depletion in the sperm plasma membrane. J. Cell Sci. 114 (2001) 3543-3555
22. Wang N., Lan D., Chen W., Matsuura F., and Tall A.R. ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc. Natl. Acad. Sci. USA 101 (2004) 9774-9779
23. Pal A., Mehn D., Molnar E., Gedey S., Meszaros P., Nagy T., Glavinas H., Janaky T., von Richter O., Bathori G., Szente L., and Krajcsi P. Cholesterol potentiates ABCG2 activity in a heterologous expression system: improved in vitro model to study function of human ABCG2. J. Pharmacol. Exp. Ther. 321 (2007) 1085-1094
24. Zhou S., Schuetz J.D., Bunting K.D., Colapietro A.M., Sampath J., Morris J.J., Lagutina I., Grosveld G.C., Osawa M., Nakauchi H., and Sorrentino B.P. The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat. Med. 7 (2001) 1028-1034