A modeling approach for understanding effects of powder flow properties on tablet weight variability

Powder Technology

Volumn 188, Issue 3, 2009, Pages 295-300

  Mehrotra, A ^a   Chaudhuri, B ^b   Faqih, A ^a   Tomassone, M S ^a   Muzzio, F J ^a  

^a The State University of New Jersey   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Cohesion; Compaction; Compression; Discrete element method; Granular flow; Tableting

Indexed keywords

ADHESION; DATA COMPRESSION; DIES; FINITE DIFFERENCE METHOD; GRANULAR MATERIALS; MATERIALS PROPERTIES; POLYDISPERSITY; THREE DIMENSIONAL;

COHESION; COMPRESSION; DISCRETE ELEMENT METHOD; GRANULAR FLOW; TABLETING;

COMPACTION;

ARTICLE; COMPRESSION; DISCRETE ELEMENT MODEL; FLOW MEASUREMENT; FORCE; METHODOLOGY; PARAMETER; PHYSICAL CHEMISTRY; TABLET;

EID: 56949102495     PISSN: 00325910     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.powtec.2008.05.016     Document Type: Article

References (31)

1. Lewis R.W., and Schrefler B.A. The Finite Element Method in the Static and Dynamics Deformation and Consolidation pf Porous Media. 2 ed. (1998), Wiley, England
2. Sinka I.C., Cunningham J.C., and Zavaliangos A. The effect of wall friction in the compaction of pharmaceutical tablets with curved faces: a validation study of the Drucker-Prager Cap model. Powder Technol. 133 (2003) 33-43
3. Coube O., and Riebel H. Numerical simulation of metal powder die compaction with special consideration of cracking. Powder Metall. 43 2 (2000) 123-131
4. Zahlan N., and Knight D.T. Modeling powder compaction and pressure cyclying. Powder Technol. 114 (2001) 112-117
5. Skrinjar O., and Larsson P. On discrete element modelling of compaction of powders with size ratio. Comput. Mater. Sci. 31 (2004) 131-146
6. Martin C.L., Bouvard D., and S. Shima. Study of particle rearrangement during powder compaction by the Discrete Element Method. J. Mech. Phys. Solids 51 (2003) 667-693
7. Sheng Y., et al. Numerical studies of uniaxial powder compaction process by 3d DEM. Eng. Comput. 21 2/3/4 (2004) 304-317
8. Liu L. Simulation of microstructural evolution during isotactic compaction of monosized spheres. J. Phys. D: Appl Phys. 36 (2003) 1881-1889
9. Gethin D.T., et al. Numerical comparision of a deformable discrete element model and an equivalent continuum analysis for the compaction of ductile porous material. Comput. Struct. 79 (2001) 1287-1294
10. Lewis R.W., et al. A combined finite-discrete element method for simulating pharmaceutical powder tableting. Int. J. Numer. Methods Eng. 62 (2005) 853-869
11. Tye C., Sun C., and Amidon G.E. Evaluation of the effects of tableting speed on the relationships between compaction pressure, tablet tensile strength, and tablet solid fraction. J. Pharm. Sci. 94 3 (2004) 465-472
12. Sanchez-Castillo F.X., Anwar J., and Heyes D.M. Molecular dynamics simulations of granular compaction: the single granule case. J. Chem. Phys. 118 10 (2003) 4636-4648
13. Chaudhuri B., et al. Cohesive effects in powder mixing in a tumbling blender. Powder Technol. 165 2 (2006) 105-114
14. Li Q., et al. Interparticle van der Waals force in powder flowability and compactibility. Int. J. Pharm. 280 (2004) 77-93
15. Gioia G., et al. Two-phase densitifcation of cohesive granular aggregates. Phys. Rev. Lett. 88 20 (2002)
16. Cundall P.A., and Strack O.D.L. A discrete numerical model for granular assemblies. Geotechnique, 29 (1979) 47-65
17. Cundall P.A. A computer model for simulating progressive large-scale movements in blocky rock systems. Proc. Symp. Int. Soc. Rock Mech. 2 (1971) 129-136
18. Dippel S., Batrouni G.G., and Wolf D.E. Collision-induced friction in the motion of a single particle on a bumpy inclined line. Phys. Rev. E. 54 (1996) 6845
19. Luding S. Stress distribution in static two dimensional granular model media in the absence of friction. Phys. Rev. E. 55 (1997) 4720
20. Ristow G., and Herrmann H. Density patterns in two-dimensional hoppers. Phys. Rev. E. 50 (1994) R5-R8
21. Thompson P.S., and Grest G.S. Granular flow: friction and the dilatancy transition. Phys. Rev. Lett. 67 (1991) 1751-1755
22. Ristow G.H. Dynamics of granular material in a rotating drum. Europhys. Lett. 34 (1996) 263
23. Khakhar D.V., et al. Transverse flow and mixing of granular materials in a rotating cylinder. Phys. Fluids 9 (1997) 31-43
24. Walton O.R., and Braun R.L. Viscosity, granular-temperature and stress calculations for shearing assemblies of inelastic, frictional disks. J. Rheol. 30 (1986) 949
25. Walton O.R. Numerical simulation of inelastic, frictional particle-particle interactions. Particulate Two-Phase Flow 16 (1992) 884-911
26. Sinka I.C., Schneider L.C.R., and Cocks A.C.F. Measurement of the flow properties of powders with special reference to die fill. Int. J. Pharm. 280 1-2 (2004) 27-38
27. Alderborn G., and Nystrom C. Pharmaceutical Powder Compaction Technology. In: Dekker M. (Ed) (1996), New York
28. Lieberman H.A., Lachman L., and Schwartz J.B. Pharmaceutical Dosage Forms, Tablets. 2 ed. (1990), New York, Dekker
29. Vachon M.G., and Chulia D. The use of energy indices in estimating powder compaction functionality of mixtures in pharmaceutical tableting. Int. J. Pharm. 177 (1999) 183-200
30. Mohammed H., Briscoe B.J., and Pitt K.G. The interrelationship between the compaction behaviour and the mechanical strength of pure pharmaceutical tablets. Chem. Eng. Sci. 60 (2005) 3941-3947
31. Antikainen O., and Yliruusi J. Determining the compression behaviour of pharmaceutical powders from the force-distance compression profile. Int. J. Pharm. 252 (2003) 253-261