Mapping of the chromosome 17 BMD QTL in the F2 male mice of MRL/MpJ × SJL/J

Genetica

Volumn 135, Issue 1, 2009, Pages 59-66

  Yu, Hongrun ^a   Edderkaoui, Bouchra ^a   Cortez, Alejandro ^a   Davidson, Heather M ^a   Wergedal, Jon E ^a,b   Baylink, David J ^a,b   Mohan, Subburaman ^a,b  

^a Jerry L Pettis Memorial VA Medical Center   (United States)

^b LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BMD; Chromosome 17; Mouse; MRL MpJ; QTL; SJL J

Indexed keywords

BIOLOGICAL MARKER; RUNX2 PROTEIN, MOUSE; TRANSCRIPTION FACTOR RUNX2; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE; VASCULOTROPIN A;

ANIMAL; ARTICLE; BODY WEIGHT; BONE DENSITY; CHROMOSOME; CHROMOSOME MAP; CROSS BREEDING; FEMALE; FEMUR; GENETIC LINKAGE; GENETICS; HUMAN; MALE; MOUSE; MOUSE STRAIN; OSTEOPOROSIS; PHYSIOLOGY; QUANTITATIVE TRAIT LOCUS;

ANIMALS; BIOLOGICAL MARKERS; BODY WEIGHT; BONE DENSITY; CHROMOSOME MAPPING; CHROMOSOMES, MAMMALIAN; CORE BINDING FACTOR ALPHA 1 SUBUNIT; CROSSES, GENETIC; FEMALE; FEMUR; HUMANS; LOD SCORE; MALE; MICE; MICE, INBRED STRAINS; OSTEOPOROSIS; QUANTITATIVE TRAIT LOCI; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

MUS;

EID: 56949091999     PISSN: 00166707     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10709-008-9258-6     Document Type: Article

References (42)

1. T Aberg XP Wang JH Kim T Yamashiro M Bei R Rice HM Ryoo I Thesleff 2004 Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis Dev Biol 270 76 93
2. Basten CJ, Weir BS, Zeng Z-B (2003) QTL cartographer: a reference manual and tutorial for QTL mapping. Department of Statistics, North Carolina State University, Raleigh
3. WG Beamer KL Shultz GA Churchill WN Frankel DJ Baylink CJ Rosen LR Donahue 1999 Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice Mamm Genome 10 1043 1049
4. WG Beamer KL Shultz LR Donahue GA Churchill S Sen JR Wergedal DJ Baylink CJ Rosen 2001 Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of mice J Bone Miner Res 16 1195 1206
5. KY Choi HJ Kim MH Lee TG Kwon HD Nah T Furuichi T Komori SH Nam YJ Kim HJ Kim HM Ryoo 2005 Runx2 regulates FGF2-induced Bmp2 expression during cranial bone development Dev Dyn 233 115 121
6. SR Cummings JL Kelsey MC Nevitt KJ O'Dowd 1985 Epidemiology of osteoporosis and osteoporotic fractures Epidemiol Rev 7 178 208
7. MM Deckers M Karperien C van der Bent T Yamashita SE Papapoulos CW Lowik 2000 Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation Endocrinology 141 1667 1674
8. HW Deng MR Stegman KM Davies T Conway RR Recker 1999 Genetic determination of variation and covariation of peak bone mass at the hip and spine J Clin Densitom 2 251 263
9. HW Deng WM Chen T Conway Y Zhou KM Davies MR Stegman H Deng RR Recker 2000 Determination of bone mineral density of the hip and spine in human pedigrees by genetic and life-style factors Genet Epidemiol 19 160 177
10. J Dequeker J Nijs A Verstraeten P Geusens G Gevers 1987 Genetic determinants of bone mineral content at the spine and radius: a twin study Bone 8 207 209
11. L Donahue W Beamer K Shultz J Hurd V Guido C Rosen 2005 QTL for bone and body composition phenotypes are sex specific in a mouse model of GH/IGF-I deficiency J Bone Miner Res 20 Supplement 1 S232
12. H Enomoto S Shiojiri K Hoshi T Furuichi R Fukuyama CA Yoshida N Kanatani R Nakamura A Mizuno A Zanma K Yano H Yasuda K Higashio K Takada T Komori 2003 Induction of osteoclast differentiation by Runx2 through receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin regulation and partial rescue of osteoclastogenesis in Runx2-/- mice by RANKL transgene J Biol Chem 278 23971 23977
13. EH Filvaroff 2003 VEGF and bone J Musculoskelet Neuronal Interact 3 304 307
14. R Gueguen P Jouanny F Guillemin C Kuntz J Pourel G Siest 1995 Segregation analysis and variance components analysis of bone mineral density in healthy families J Bone Miner Res 10 2017 2022
15. QY Huang RR Recker HW Deng 2003 Searching for osteoporosis genes in the post-genome era: progress and challenges Osteoporos Int 14 701 715
16. N Ishimori R Li KA Walsh R Korstanje JA Rollins P Petkov MT Pletcher T Wiltshire LR Donahue CJ Rosen WG Beamer GA Churchill B Paigen 2006 Quantitative trait loci that determine BMD in C57BL/6J and 129S1/SvImJ inbred mice J Bone Miner Res 21 105 112
17. C Kesavan S Mohan SK Srivastava S Kapoor JE Wergedal H Yu DJ Baylink 2006 Identification of genetic loci that regulate bone adaptive response to mechanical loading in C57BL/6J and C3H/HeJ intercross Bone 39 634 643
18. OF Klein AS Carlos KA Vartanian VK Chambers EJ Turner TJ Phillips JK Belknap ES Orwoll 2001 Confirmation and fine mapping of chromosomal regions influencing peak bone mass in mice J Bone Miner Res 16 1953 1961
19. RF Klein J Allard Z Avnur T Nikolcheva D Rotstein AS Carlos M Shea RV Waters JK Belknap G Peltz ES Orwoll 2004 Regulation of bone mass in mice by the lipoxygenase gene Alox15 Science 303 229 232
20. X Li S Mohan W Gu J Wergedal DJ Baylink 2001 Quantitative assessment of forearm muscle size, forelimb grip strength, forearm bone mineral density, and forearm bone size in determining humerus breaking strength in 10 inbred strains of mice Calcif Tissue Int 68 365 369
21. X Li G Masinde W Gu J Wergedal S Mohan DJ Baylink 2002 Genetic dissection of femur breaking strength in a large population (MRL/MpJ x SJL/J) of F2 Mice: single QTL effects, epistasis, and pleiotropy Genomics 79 734 740
22. GL Masinde X Li W Gu J Wergedal S Mohan DJ Baylink 2002 Quantitative trait loci for bone density in mice: the genes determining total skeletal density and femur density show little overlap in F2 mice Calcif Tissue Int 71 421 428
23. GL Masinde J Wergedal H Davidson S Mohan R Li X Li DJ Baylink 2003 Quantitative trait loci for periosteal circumference (PC): identification of single loci and epistatic effects in F2 MRL/SJL mice Bone 32 554 560
24. LJ Melton 3rd SH Kan MA Frye HW Wahner WM O'Fallon BL Riggs 1989 Epidemiology of vertebral fractures in women Am J Epidemiol 129 1000 1011
25. ES Orwoll JK Belknap RF Klein 2001 Gender specificity in the genetic determinants of peak bone mass J Bone Miner Res 16 1962 1971
26. RR Recker HW Deng 2002 Role of genetics in osteoporosis Endocrine 17 55 66
27. WR Rice 1989 Analyzing tables of statistical tests Evolution 43 223 225
28. M Shimizu K Higuchi B Bennett C Xia T Tsuboyama S Kasai T Chiba H Fujisawa K Kogishi H Kitado M Kimoto N Takeda M Matsushita H Okumura T Serikawa T Nakamura TE Johnson M Hosokawa 1999 Identification of peak bone mass QTL in a spontaneously osteoporotic mouse strain Mamm Genome 10 81 87
29. M Shimizu K Higuchi S Kasai T Tsuboyama M Matsushita M Mori Y Shimizu T Nakamura M Hosokawa 2001 Chromosome 13 locus, Pbd2, regulates bone density in mice J Bone Miner Res 16 1972 1982
30. CW Slemenda JC Christian CJ Williams JA Norton CC Johnston Jr 1991 Genetic determinants of bone mass in adult women: a reevaluation of the twin model and the potential importance of gene interaction on heritability estimates J Bone Miner Res 6 561 567
31. H Sowa H Kaji GN Hendy L Canaff T Komori T Sugimoto K Chihara 2004 Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2 J Biol Chem 279 40267 40275
32. CH Turner Q Sun J Schriefer N Pitner R Price ML Bouxsein CJ Rosen LR Donahue KL Shultz WG Beamer 2003 Congenic mice reveal sex-specific genetic regulation of femoral structure and strength Calcif Tissue Int 73 297 303
33. Van Ooijen JW (2004) MapQTL® 5, software fore the mapping of quantitative trait loci in experimental populations. Kyazma B.B., Wageningen
34. JE Wergedal MH Sheng CL Ackert-Bicknell WG Beamer DJ Baylink 2002 Mouse genetic model for bone strength and size phenotypes: NZB/B1NJ and RF/J inbred strains Bone 31 670 674
35. JE Wergedal MH Sheng CL Ackert-Bicknell WG Beamer DJ Baylink 2005 Genetic variation in femur extrinsic strength in 29 different inbred strains of mice is dependent on variations in femur cross-sectional geometry and bone density Bone 36 111 122
36. G Xiao D Jiang C Ge Z Zhao Y Lai H Boules M Phimphilai X Yang G Karsenty RT Franceschi 2005 Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression J Biol Chem 280 30689 30696
37. S Yang D Wei D Wang M Phimphilai PH Krebsbach RT Franceschi 2003 In vitro and in vivo synergistic interactions between the Runx2/Cbfa1 transcription factor and bone morphogenetic protein-2 in stimulating osteoblast differentiation J Bone Miner Res 18 705 715
38. DW Young J Pratap A Javed B Weiner Y Ohkawa A van Wijnen M Montecino GS Stein JL Stein AN Imbalzano JB Lian 2005 SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation J Cell Biochem 94 720 730
39. H Yu S Mohan GL Masinde DJ Baylink 2005 Mapping the dominant would healing and soft tissue regeneration QTL in MRL × SJL Mamm Genome 16 918 924
40. E Zelzer W McLean YS Ng N Fukai AM Reginato S Lovejoy PA D'Amore BR Olsen 2002 Skeletal defects in VEGF (120/120) mice reveal multiple roles for VEGF in skeletogenesis Development 129 1893 1904
41. E Zelzer R Mamluk N Ferrara RS Johnson E Schipani BR Olsen 2004 VEGFA is necessary for chondrocyte survival during bone development Development 131 2161 2171
42. Q Zheng G Zhou R Morello Y Chen X Garcia-Rojas B Lee 2003 Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte-specific expression in vivo J Cell Biol 162 833 842