Characterization of a new polyvalent antivenom (Antivipmyn® Africa) against African vipers and elapids

Toxicon

Volumn 52, Issue 8, 2008, Pages 881-888

  Ramos Cerrillo, Blanca ^a   de Roodt, Adolfo R ^b   Chippaux, Jean Philippe ^c   Olguín, Laura ^d   Casasola, Andrea ^a   Guzmán, Guadalupe ^d   Paniagua Solís, Jorge ^d,e   Alagón, Alejandro ^a   Stock, Roberto P ^a  

^a INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

^b Administracion Nacional   (Argentina)

^c INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (France)

^d Laboratorios Silanes SA de CV   (Mexico)

^e Instituto Bioclon SA de CV   (Mexico)

Author keywords

African snakes; Antivenom; Neutralization; Pre clinical testing

Indexed keywords

ANTIVIPMYN; SNAKE VENOM; UNCLASSIFIED DRUG; VENOM ANTISERUM; VIPER VENOM;

AFRICA; ARTICLE; BIOCHEMICAL COMPOSITION; CONTROLLED STUDY; DRUG EFFECT; DRUG MANUFACTURE; DRUG STABILITY; ELECTROPHORESIS; ENVENOMATION; LETHALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; SNAKE;

AFRICA; ANIMALS; ANTIVENINS; BLOOD COAGULATION DISORDERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; ELAPID VENOMS; HEMORRHAGE; HORSES; LETHAL DOSE 50; MICE; NECROSIS; NEUTRALIZATION TESTS; SPECIES SPECIFICITY; VIPER VENOMS;

BITIS; DENDROASPIS; ECHIS; ECHIS OCELLATUS; ELAPIDAE; EQUIDAE; NAJA; SERPENTES; VIPERINAE;

EID: 56949091292     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2008.09.002     Document Type: Article

References (34)

1. Chippaux J.-P. Snake-bites: appraisal of the global situation. Bull. WHO 76 (1998) 515-524
2. Chippaux J.P. The development and use of immunotherapy in Africa. Toxicon 36 (1998) 1503-1506
3. Chippaux J.-P. The treatment of snakebites: analysis of requirements and assessment of therapeutic efficacy in tropical Africa. In: Ménez A. (Ed). Perspectives in Molecular Toxinology (2002), John Wiley and Sons 457-472
4. Chippaux J.P. Evaluation de la situation épidémiologique et des capacités de prise en charge des envenimations ophidiennes en Afrique subsaharienne francophone. Bull. Soc. Pathol. Exot. 98 (2005) 263-268
5. Chippaux J.-P. Snake Venoms and Envenomations (2006), IRD Éditions. Krieger Publishing Co., Malabar, Florida, USA pp. 169-193
6. Chippaux J.-P., and Goyffon M. Venoms, antivenoms and immunotherapy. Toxicon 36 (1998) 823-846
7. Chippaux J.-P., Williams V., and White J. Snake venom variability: methods of study, results and interpretation. Toxicon 29 (1991) 1279-1303
8. 2: results of a clinical trial in northern Cameroon. Am. J. Trop. Med. Hyg. 61 (1999) 1017-1018
9. Chippaux J.-P., Stock R.P., and Alagón A. Report of the 2nd international conference on envenomationsin Africa (Deuxième Colloque International sur les Envenimations en Afrique). Toxicon 46 (2005) 115-118
10. 2 polyvalent equine antivenom for African snakebites in Benin. Am. J. Trop. Med. Hyg. 77 (2007) 538-546
11. Christensen P.A. South African Snake Venoms and Antivenoms (1959), South African Institute of Medical Research, Johannesburg 1955. Reprinted in Copenhagen, 1959
12. de Roodt A.R., Paniagua-Solís J., Dolab J.A., Estévez-Ramírez J., Ramos-Cerrillo B., Litwin S., Dokmetjian J.C., and Alagón A. Effectiveness of two common antivenoms for North, Central and South American Micrurus envenomations. J. Toxicol. Clin. Toxicol. 42 (2004) 171-178
13. 2 antivenoms. An example: new polyvalent European antivenom (equine). In: Bon C., and Goyffon M. (Eds). Envenomations and their Treatments (1996), Editions Fondation Marcel Mérieux, Lyon 161-172
14. Gutiérrez J.M., Rojas E., Quesada L., León G., Nuñez J., Laing G.D., Sasa M., Renjifo J.M., Nasidi A., Warrell D.A., Theakston R.D.G., and Rojas G. Pan-African polyspecific antivenom produced by caprylic acid purification of horse IgG: an alternative to the antivenom crisis in Africa. Trans. Royal Soc. Trop. Med. Hyg. 99 (2005) 468-475
15. Gutiérrez J.M., Theakston R.D.G., and Warrell D.A. Confronting the neglected problem of snakebite envenomation: the need for a global partnership. PLoS Med. 3 (2006) 0727-0731
16. Howes J.-M., Theakston R.D.G., and Laing G.D. Neutralization of the hemorrhagic activities of viperine snake venoms and venom metalloproteinases using synthetic peptide inhibitors and chelators. Toxicon 49 (2007) 734-739
17. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
18. Laing G.D., Theakston R.D.G., Leite R.P., Dias Da Silva W., and Warrell D.A. Comparison of the potency of three Brazilian Bothrops antivenoms using in vivo rodent and in vitro assays. Toxicon 30 (1992) 1219-1225
19. Laing G.D., Renjifo J.M., Ruiz F., Harrison R.A., Nasidi A., Gutiérrez J.M., Rowley P.D., Warrell D.A., and Theakston R.D.G. A new Pan African polyspecific antivenom developed in response to the antivenom crisis in Africa. Toxicon 42 (2003) 35-41
20. 2 fragments of antibodies and method for the preparation thereof. U.S. Patent 6,709,655B2, WO 02/068475 A2. March 23.
21. Markland Jr. E.S. Snake venoms and the hemostatic system. Toxicon 36 (1998) 1749-1800
22. Pugh R.N.H., Bourdillon C.C.M., Theakston R.D.G., and Reid H.A. Bites by the carpet viper in the Niger Valley. The Lancet 2 (1979) 625-627
23. Stock R.P., Massougbodji A., Alagón A., and Chippaux J.-P. Bringing antivenoms to Sub-Saharan Africa. Nat. Biotechnol. 25 (2007) 173-177
24. Theakston R.D.G., and Reid H.A. Development of simple standard assay procedures for the characterization of snake venoms. Bull. World Health Org. 61 (1983) 949-956
25. Theakston R.D.G., and Warrell D.A. Crisis in snake antivenom supply for Africa. The Lancet 356 (2000) 2104
26. Theakston R.D.G., Warrell D.A., and Griffiths E. Report of a WHO workshop on the standardization and control of antivenoms. Toxicon 41 (2003) 541-557
27. Tuck S., and Ng R. Protein assays. In: Rodriguez-Diaz R., Wehr T., and Tuck S. (Eds). Analytical Techniques for Biopharmaceutical Development (2005), Marcel Dekker, New York 14-24
28. Warrell D.A. Clinical toxicology of snakebite in Africa and the Middle East/Arabian peninsula. In: White J., and Meier J. (Eds). Handbook of Clinical Toxicology of Animal Venoms and Poisons (1995), CRC Press 433-492
29. Warrell D.A., and Arnett C. The importance of bites by the sawscaled or carpet viper (Echis carinatus): epidemiological studies in Nigeria and a review of the world literature. Acta Trop. 33 (1976) 307-341
30. Warrell D.A., Ormerod L.D., and Davidson N.McD. Bites by the night adder (Causus maculatus) and burrowing vipers (Genus Atractaspis) in Nigeria. Am. J. Trop. Med. Hyg. 25 (1976) 517-524
31. White J., Warrell D.A., Eddleston M., Currie B.J., Whyte I.M., and Isbister G.K. Clinical toxinology - where are we now?. J. Toxicol. Clin. Toxicol. 41 (2003) 263-276
32. World Health Organization. Progress in the Characterization of Venoms and Standardization of Antivenoms. Offset Publication (1981), WHO, Geneva
33. Wüster W., and Broadley D.G. Get an eyeful of this: a new species of giant spitting cobra from eastern and north-eastern Africa (Squamata: Serpentes: Elapidae: Naja). Zootaxa 1532 (2007) 51-68
34. Wüster W., Crookes S., Ineich I., Mané Y., Pook C.E., Trape J.-F., and Broadley D.G. The phylogeny of cobras inferred from mitochondrial DNA sequences: evolution of venom spitting and the phylogeography of the African spitting cobras (Serpentes: Elapidae: Naja nigricollis complex). Mol. Phylogen. Evol. 45 (2007) 437-453