A dog is not a rat: Importance of understanding species differences in drug absorption, distribution, metabolism and excretion (ADME)

Veterinary Journal

Volumn 179, Issue 1, 2009, Pages 8-9

  Deshmukh, Rahul ^a   Blomme, Eric A G ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IVERMECTIN; LIPID;

BREEDING; DOG; DRUG ABSORPTION; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG FORMULATION; DRUG HALF LIFE; DRUG METABOLISM; EDITORIAL; GENETIC POLYMORPHISM; NONHUMAN; SPECIES DIFFERENCE; VETERINARY MEDICINE;

ANIMALS; ENERGY METABOLISM; INTESTINAL ABSORPTION; METABOLIC CLEARANCE RATE; SPECIES SPECIFICITY; VETERINARY DRUGS;

CANIS FAMILIARIS; RATTUS;

EID: 56849129486     PISSN: 10900233     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tvjl.2008.11.008     Document Type: Editorial

References (5)

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3. Mealey K.L., Bentjen S.A., Gay J.M., and Cantor G.H. Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene. Pharmacogenetics 11 (2001) 727-733
4. Omura S. Ivermectin: 25 years and still going strong. International Journal of Antimicrobial Agents 31 (2008) 91-98
5. Wall R., and Strong L. Environmental consequences of treating cattle with the antiparasitic drug ivermectin. Nature 327 (1987) 418-421