Effects of trichostatin A and paclitaxel on apoptosis and microtubule stabilization in endometrial carcinoma cells: An in vitro research

National Medical Journal of China

Volumn 88, Issue 34, 2008, Pages 2427-2431

  Jiang, Shu Juan ^a   Zhang, Song ^a   Mu, Xiao Yan ^a   Li, Wei ^a   Wang, Yan ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Aoptposis; Endometrial neoplasms; Microtubulin; Paclitaxel; Trichostatin A

Indexed keywords

ACETYLATED MICROTUBULIN; CASPASE 9; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PACLITAXEL; TRICHOSTATIN A; TUBULIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CELL GROWTH; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; ENDOMETRIUM CARCINOMA; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MICROTUBULE ASSEMBLY; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; STAINING; WESTERN BLOTTING;

APOPTOSIS; CELL LINE, TUMOR; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; HYDROXAMIC ACIDS; MICROTUBULE PROTEINS; MICROTUBULES; PACLITAXEL;

EID: 56849100435     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Egler V, Korur S, Failly M, et al. Histone deacetylase inhibition and blockade of the glycolytic pathway synergistically induce glioblastoma cell death. Clin Cancer Res, 2008, 14:3132-3140.
2. Liao PC, Tan SK, Lieu CH, et al. Involvement of endoplasmic reticulum in paclitaxel-induced apoptosis. J Cell Biochem, 2008, 104:1509-1523.
3. Podratz KC, Mariani A. Uterine papillary serous carcinomas: the exigency for clinical trials. Gynecol Oncol, 2003, 91: 461-462.
4. Barrett RJ, Blessing JA, Homesley HD, et al. Circadian-timed combination doxorubicin-cisplatin chemotherapy for advanced endometrial carcinoma. A phase II study of the Gynecologic Oncology Group. Am J Clin Oncol, 1993, 16: 494-496.
5. Zhang Y, Li N, Caron C, et al. HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J, 2003,22: 1168-1179.
6. Baum SG, Wittner M, Nadler JP, et al. Taxol, a microtubule stabilizing agent, blocks the replication of Trypanosoma cruzi. Proc Natl Acad Sci U S A, 1981, 78: 4571-4575.
7. Duan H, Heckman CA, Boxer LM. Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas. Mol Cell Biol, 2005, 25: 1608-1619.
8. Nuydens R, Dispersyn G, Van Den Keiboom, et al. Bcl-2 protects against apoptosis-related microtubule alterations in neuronal cells. Apoptosis, 2000, 5: 43-51.
9. Blagosklonny MV, Schulte TW, Nguyen P, et al. Taxol induction of p21WAF1 and p53 requires c-raf-1. Cancer Res, 1995, 55: 4623-4626.
10. Etienne-Manneville S, Hal A. Rho GTPases in cell biology. Nature, 2002, 420:629-635.