Hypocortisolemic clamp unmasks jointly feedforward- and feedback-dependent control of overnight ACTH secretion

European Journal of Endocrinology

Volumn 159, Issue 5, 2008, Pages 561-568

  Iranmanesh, Ali ^a   Veldhuis, Johannes D ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; GLUCOCORTICOID; KETOCONAZOLE; METYRAPONE; PLACEBO;

ADRENAL CORTEX INSUFFICIENCY; ADRENAL FUNCTION; ADULT; ARTICLE; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; CORTICOTROPIN RELEASE; ENDOCRINE FUNCTION TEST; ENTROPY; FEEDBACK SYSTEM; HORMONAL REGULATION; HORMONE INHIBITION; HUMAN; HYPOCORTISOLEMIA; HYPOCORTISOLEMIC CLAMP; HYPOTHALAMUS FUNCTION; MALE; PRIORITY JOURNAL; WAVEFORM;

ADRENOCORTICOTROPIC HORMONE; ADULT; CIRCADIAN RHYTHM; ENTROPY; ENZYME INHIBITORS; FEEDBACK, BIOCHEMICAL; GLUCOCORTICOIDS; HUMANS; HYDROCORTISONE; HYPOTHALAMUS; KETOCONAZOLE; MALE; METYRAPONE; MIDDLE AGED; PLACEBOS;

EID: 56749183854     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-08-0417     Document Type: Article

References (37)

1. Gallagher TF, Yoshida K, Roffwarg HD, Fukushida DK, Weitzman ED & Hellman L. ACTH and cortisol secretory patterns in man. Journal of Clinical Endocrinology and Metabolism 1973 36 1058-1073.
2. Horrocks PM, Jones AF, Ratcliffe WA, Holder G, White A, Holder R, Ratcliffe JG & London DR. Patterns of ACTH and cortisol pulsatility over twenty-four hours in normal males and females. Clinical Endocrinology 1990 32 127-134.
3. Iranmanesh A, Short D, Lizarralde G & Veldhuis JD. Intensive venous sampling paradigms disclose high-frequency ACTH release episodes in normal men. Journal of Clinical Endocrinology and Metabolism 1990 71 1276-1283.
4. Keenan DM, Licinio J & Veldhuis JD. A feedback-controlled ensemble model of the stress-responsive hypothalamo-pituitary-adrenal axis. PNAS 2001 98 4028-4033.
5. Rivier C & Vale W. Modulation of stress-induced ACTH release by corticotropin-releasing factor, catecholamines and vasopressin. Nature 1983 305 325-327.
6. Fink G, Robinson IC & Tannahill LA. Effects of adrenalectomy and glucocorticoids on the peptides CRF-41, AVP and oxytocin in rat hypophysial portal blood. Journal of Physiology 1988 401 329-345.
7. Fehm HL, Voigt KH, Kummer G, Lang R & Pfeiffer EF. Differential and integral corticosteroid feedback effects on ACTH secretion in hypoadrenocorticism. Journal of Clinical Investigation 1979 63 247-253.
8. Erkut ZA, Pool C & Swaab DF. Glucocorticoids suppress corticotropin-releasing hormone and vasopressin expression in human hypothalamic neurons. Journal of Clinical Endocrinology and Metabolism 1998 83 2066-2073.
9. Veldhuis JD, Iranmanesh A, Naftolowitz D, Tatham N, Cassidy F & Carroll BJ. Corticotropin secretory dynamics in humans under low glucocorticoid feedback. Journal of Clinical Endocrinology and Metabolism 2001 86 5554-5563.
10. Keenan DM, Roelfsema F & Veldhuis JD. Endogenous ACTH concentration-dependent drive of pulsatile cortisol secretion in the human. American Journal of Physiology. Endocrinology and Metabolism 2004 287 E652-E661.
11. Keenan DM & Veldhuis JD. Cortisol feedback state governs adrenocorticotropin secretory-burst shape, frequency and mass in a dual-waveform construct: time-of-day dependent regulation. American Journal of Physiology 2003 285 R950-R961.
12. Veldhuis JD, Iranmanesh A, Johnson ML & Lizarralde G. Twenty-four hour rhythms in plasma concentrations of adenohypophyseal hormones are generated by distinct amplitude and/or frequency modulation of underlying pituitary secretory bursts. Journal of Clinical Endocrinology and Metabolism 1990 71 1616-1623.
13. Pincus SM. Irregularity and asynchrony in biologic network signals. Methods in Enzymology 2000 321 149-182.
14. Hartman ML, Pincus SM, Johnson ML, Matthews DH, Faunt LM, Vance ML, Thorner MO & Veldhuis JD. Enhanced basal and disorderly growth hormone secretion distinguish acromegalic from normal pulsatile growth hormone release. Journal of Clinical Investigation 1994 94 1277-1288.
15. Pincus SM, Gevers E, Robinson ICAF, van den Berg G, Roelfsema F, Hartman ML & Veldhuis JD. Females secrete growth hormone with more process irregularity than males in both human and rat. American Journal of Physiology 1996 270 E107-E115.
16. Veldhuis JD, Straume M, Iranmanesh A, Mulligan T, Jaffe CA, Barkan A, Johnson ML & Pincus SM. Secretory process regularity monitors neuroendocrine feedback and feedforward signaling strength in humans. American Journal of Physiology 2001 280 R721-R729.
17. Pincus SM. Quantifying complexity and regularity of neurobiological systems. Methods in Neuroscience 1995 28 336-363.
18. Keenan DM, Chattopadhyay S & Veldhuis JD. Composite model of time-varying appearance and disappearance of neurohormone pulse signals in blood. Journal of Theoretical Biology 2005 236 242-255.
19. Keenan DM, Roelfsema F, Biermasz N & Veldhuis JD. Physiological control of pituitary hormone secretory-burst mass, frequency and waveform: a statistical formulation and analysis. American Journal of Physiology 2003 285 R664-R673.
20. Labeur M, Arzt E, Stalla GK & Paez-Pereda M. New perspectives in the treatment of Cushing's syndrome. Current Drug Targets. Immune, Endocrine and Metabolic Disorders 2004 4 335-342.
21. Akaike H. A new look at the statistical model identification. IEEE Transactions on Automatic Control 1974 19 716-723.
22. Pincus SM, Hartman ML, Roelfsema F, Thorner MO & Veldhuis JD. Hormone pulsatility discrimination via coarse and short time sampling. American Journal of Physiology 1999 277 E948-E957.
23. Veldhuis JD, Metzger DL, Martha PM Jr, Mauras N, Kerrigan JR, Keenan B, Rogol AD & Pincus SM. Estrogen and testosterone, but not a non-aromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replacement. Journal of Clinical Endocrinology and Metabolism 1997 82 3414-3420.
24. Veldhuis JD, Johnson ML, Veldhnis OL, Straume M & Pincus S. Impact of pulsatility on the ensemble orderliness (approximate entropy) of neurohormone secretion. American Journal of Physiology 2001 281 R1975-R1985.
25. Fisher LD &van Belle G. Descriptive statistics. In Biostatistics: A Methodology for the Health Sciences, pp 58-74. New York: John Wiley & Sons, 1996.
26. Holland LJ, Van Der HJ, Feelders R, van Aken MO, Van Koetsveld PM, Waaijers M, Sprij-Mooij D, Bruns C, Weckbecker G, De Herder WW, Beckers A & Lamberts SW. The multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5. European Journal of Endocrinology 2005 152 645-654.
27. Luque RM, Gahete MD, Hochgeschwender U & Kineman RD. Evidence that endogenous SST inhibits ACTH and ghrelin expression by independent pathways. American Journal of Physiology. Endocrinology and Metabolism 2006 291 E395-E403.
28. Silva AP, Schoeffter P, Weckbecker G, Bruns C & Schmid HA. Regulation of CRH-induced secretion of ACTH and corticosterone by SOM230 in rats. European Journal of Endocrinology 2005 153 R7-R10.
29. Thorner MO, Vance ML, Hartman ML, Holl RW, Evans WS, Veldhuis JD, Van Cauter E, Copinschi G & Bowers CY. Physiological role of somatostatin on growth hormone regulation in humans. Metabolism 1990 39 40-42.
30. Peterfreund RA & Vale WW. Ovine corticotropin-releasing factor stimulates somatostatin secretion from cultured brain cells. Endocrinology 1983 112 1275-1278.
31. Rigamonti AE, Bonomo SM, Cella SG & Muller EE. GH and cortisol rebound rise during and following a somatostatin infusion: studies in dogs with the use of a GH-releasing peptide. Journal of Endocrinology 2002 174 387-394.
32. von Zastrow M & Castle JD. Protein sorting among two distinct export pathways occurs from the content of maturing exocrine storage granules. Journal of Cell Biology 1987 105 2675-2684.
33. Nickel W & Wieland FT. Biosynthetic protein transport through the early secretory pathway. Histochemistry and Cell Biology 1998 109 477-486.
34. Bergendahl M, Iranmanesh A, Mulligan T & Veldhuis JD. Impact of age on cortisol secretory dynamics basally and as driven by nutrient-withdrawal stress. Journal of Clinical Endocrinology and Metabolism 2000 85 2203-2214.
35. Iranmanesh A, Veldhuis JD, Johnson ML & Lizarralde G. Twenty-four hour pulsatile and circadian patterns of cortisol secretion in alcoholic men. Journal of Andrology 1989 10 54-63.
36. Carroll BJ, Cassidy F, Naftolowitz D, Tatham NE, Wilson WH, Iranmanesh A, Liu PY & Veldhuis JD. Pathophysiology of hypercortisolism in depression. Acta Psychiatrica Scandinavica 2007 115 90-103.
37. Van Cauter E, Leproult R & Kupfer DJ. Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol. Journal of Clinical Endocrinology and Metabolism 1996 81 2468-2473.