Effects of berberine on expression of hepatocyte nuclear factor 4α and glucokinase activity in mouse primary hepatocytes

Zhongguo Zhongyao Zazhi

Volumn 33, Issue 18, 2008, Pages 2105-2109

  Yan, Zhong Qing ^a   Leng, San Hua ^a   Lu, Fu Er ^a   Lu, Xiao Hong ^b   Dong, Hui ^a   Gao, Zhi Qiang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Hubei Biocause Pharmaceutical Co Ltd   (China)

Author keywords

Berberine; Glucokinase; Hepatocyte nuclear factor; Primary hepatocytes

Indexed keywords

BERBERINE; GLUCOKINASE; HEPATOCYTE NUCLEAR FACTOR 4; PLANT EXTRACT;

ANIMAL; ARTICLE; CELL CULTURE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; LIVER CELL; MALE; METABOLISM; MOUSE;

ANIMALS; BERBERINE; CELL SURVIVAL; CELLS, CULTURED; GENE EXPRESSION REGULATION; GLUCOKINASE; HEPATOCYTE NUCLEAR FACTOR 4; HEPATOCYTES; MALE; MICE; PLANT EXTRACTS;

EID: 56749183415     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Fajans S S, Bell G I, Polonsky S K. Molecular meshanisms and clinical pathophysiology of maturity-onset diabetes of the young [J] . N Engl J Med, 2001,345(13):971.
2. Kulkarni R N, Kahn C R. HNFs-linking the liver and pancreatic islets in diabetes[J]. Science, 2004,303(5662):1311.
3. Odom D T, Zizlsperger N, Gordon D B, et al. Control of pancreatic and liver gene expression by HNF transcription factors [J]. Science, 2004,303(5662):1378.
4. Duncan S A, Navas M A, Dufort D, et al. Regulation of a transcription factor network required for differentiation and metabolism [J]. Science, 1998,281(5377):692.
5. Yin Jun, Hu Renming, Chen Mingdao, et al. Effects of berberine on glucose metabolism in vitro[J]. Metabolism, 2002,51(11): 1439.
6. Kong W, Wei J, Abidi P, et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins[J]. Nature Medicine, 2004,10(12):1344.
7. Seglen P O. Preparation of isolated rat liver cells[J]. Methods Cell Bio, 1976,13:29.
8. Aalinkeel R, Srinivasan M, Kalhan S C. A dietary intervention (high carbohydrate) during the neonatal period causes islet dysfunction in rats[J]. Am J Physiol Endocrinol Metab, 1999,277 (6):1061.
9. Hatzis P, Kyrmizi I, Talianidis I, et al. Mitogen-activated protein kinase-mediated disruption of enhancer-promoter communication inhibits hepatocyte nuclear factor 4α expression [J]. Mol Cell Biol, 2006,26(19):7017.