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Volumn 18, Issue 8, 2008, Pages 1475-1481

Disulfide bond bridged divalent antibody-toxin, (Fab-PE38fl)2, with the toxin PE38 fused to the light chain

Author keywords

Antibody refolding; Cytotoxicity; Divalent antibody toxin; Homodimer; Light chain toxin fusion; Pseudomonas exotoxin A

Indexed keywords

CYSTEINE; HOMODIMER; IMMUNOGLOBULIN F(AB')1 FRAGMENT; IMMUNOGLOBULIN F(AB')2 FRAGMENT; IMMUNOGLOBULIN F(AB')3 FRAGMENT; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN LIGHT CHAIN; PSEUDOMONAS EXOTOXIN; UNCLASSIFIED DRUG;

EID: 56749176169     PISSN: 10177825     EISSN: 17388872     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (3)

References (20)
  • 2
    • 0029144167 scopus 로고
    • Characterization of B1(Fv)PE38 and B1(dsFv)PE38: Single-chain and disulfide-stabilized Fv immunotoxins with increased activity that cause complete remissions of established human carcinoma xenografts in nude mice
    • Benhar, I. and I. Pastan. 1995. Characterization of B1(Fv)PE38 and B1(dsFv)PE38: Single-chain and disulfide-stabilized Fv immunotoxins with increased activity that cause complete remissions of established human carcinoma xenografts in nude mice. Clin. Cancer Res. 1: 1023-1029.
    • (1995) Clin. Cancer Res , vol.1 , pp. 1023-1029
    • Benhar, I.1    Pastan, I.2
  • 3
    • 0026510381 scopus 로고
    • Independent domain folding of Pseudomonas exotoxin and single-chain immunotoxins: Influence of interdomain connections
    • Brinkmann, U., J. Buchner, and I. Pastan. 1992. Independent domain folding of Pseudomonas exotoxin and single-chain immunotoxins: Influence of interdomain connections. Proc. Natl. Acad. Sci. USA 89: 3075-3079.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 3075-3079
    • Brinkmann, U.1    Buchner, J.2    Pastan, I.3
  • 4
    • 0026005994 scopus 로고
    • B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice
    • Brinkmann, U., L. H. Pai, D. J. FitzGerald, M. Willingham, and I. Pastan. 1991. B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice. Proc. Natl. Acad. Sci. USA 88: 8616-8620.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 8616-8620
    • Brinkmann, U.1    Pai, L.H.2    FitzGerald, D.J.3    Willingham, M.4    Pastan, I.5
  • 5
    • 0026792807 scopus 로고
    • A method for increasing the yield of properly folded recombinant fusion proteins: Single-chain immunotoxins from renaturation of bacterial inclusion bodies
    • Buchner, J., I. Pastan, and U. Brinkmann. 1992. A method for increasing the yield of properly folded recombinant fusion proteins: Single-chain immunotoxins from renaturation of bacterial inclusion bodies. Anal. Biochem. 205: 263-270.
    • (1992) Anal. Biochem , vol.205 , pp. 263-270
    • Buchner, J.1    Pastan, I.2    Brinkmann, U.3
  • 6
    • 0006454079 scopus 로고
    • Renaturation, purification and characterization of recombinant Fab-fragments produced in Escherichia coli
    • Buchner, J. and R. Rudolph. 1991. Renaturation, purification and characterization of recombinant Fab-fragments produced in Escherichia coli. Biotechnology (NY) 9: 157-162.
    • (1991) Biotechnology (NY) , vol.9 , pp. 157-162
    • Buchner, J.1    Rudolph, R.2
  • 7
    • 0028176359 scopus 로고
    • B3(Fab)-PE38M: A recombinant immunotoxin in which a mutant form of Pseudomonas exotoxin is fused to the Fab fragment of monoclonal antibody B3
    • Choe, M., K. O. Webber, and I. Pastan. 1994. B3(Fab)-PE38M: A recombinant immunotoxin in which a mutant form of Pseudomonas exotoxin is fused to the Fab fragment of monoclonal antibody B3. Cancer Res. 54: 3460-3467.
    • (1994) Cancer Res , vol.54 , pp. 3460-3467
    • Choe, M.1    Webber, K.O.2    Pastan, I.3
  • 8
    • 0035924897 scopus 로고    scopus 로고
    • A divalent immunotoxin formed by the disulfide bond between hinge regions of Fab domain
    • Choi, S. H., J. E. Kim, Y. C. Lee, Y. J. Jang, I. Pastan, and M. H. Choe. 2001. A divalent immunotoxin formed by the disulfide bond between hinge regions of Fab domain. Bull. Kor. Chem. Soc. 22: 1361-1365.
    • (2001) Bull. Kor. Chem. Soc , vol.22 , pp. 1361-1365
    • Choi, S.H.1    Kim, J.E.2    Lee, Y.C.3    Jang, Y.J.4    Pastan, I.5    Choe, M.H.6
  • 10
    • 0023812258 scopus 로고
    • Comparison of the cytotoxic potency of T101 Fab, F(ab')2 and whole IgG immunotoxins
    • Derocq, J. M., P. Casellas, G. Laurent, S. Ravel, H. Vidal, and F. Jansen. 1988. Comparison of the cytotoxic potency of T101 Fab, F(ab')2 and whole IgG immunotoxins. J. Immunol. 141: 2837-2843.
    • (1988) J. Immunol , vol.141 , pp. 2837-2843
    • Derocq, J.M.1    Casellas, P.2    Laurent, G.3    Ravel, S.4    Vidal, H.5    Jansen, F.6
  • 11
    • 0026015565 scopus 로고
    • Agents which reverse multidrug-resistance are inhibitors of [3H]vinblastine transport by isolated vesicles
    • Horio, M., E. Lovelace, I. Pastan, and M. M. Gottesman. 1991. Agents which reverse multidrug-resistance are inhibitors of [3H]vinblastine transport by isolated vesicles. Biochim. Biophys. Acta 1061: 106-110.
    • (1991) Biochim. Biophys. Acta , vol.1061 , pp. 106-110
    • Horio, M.1    Lovelace, E.2    Pastan, I.3    Gottesman, M.M.4
  • 12
    • 0023657391 scopus 로고
    • Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli
    • Hwang, J., D. J. FitzGerald, S. Adhya, and I. Pastan. 1987. Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli. Cell 48: 129-136.
    • (1987) Cell , vol.48 , pp. 129-136
    • Hwang, J.1    FitzGerald, D.J.2    Adhya, S.3    Pastan, I.4
  • 13
    • 0028291703 scopus 로고
    • Anti-Tac(Fab)-PE40, a recombinant double-chain immunotoxin which kills interleukin-2-receptor-bearing cells and induces complete remission in an in vivo tumor model
    • Kreitman, R. J., C. N. Chang, D. V. Hudson, C. Queen, P. Bailon, and I. Pastan. 1994. Anti-Tac(Fab)-PE40, a recombinant double-chain immunotoxin which kills interleukin-2-receptor-bearing cells and induces complete remission in an in vivo tumor model. Int. J. Cancer 57: 856-864.
    • (1994) Int. J. Cancer , vol.57 , pp. 856-864
    • Kreitman, R.J.1    Chang, C.N.2    Hudson, D.V.3    Queen, C.4    Bailon, P.5    Pastan, I.6
  • 14
    • 1242271212 scopus 로고    scopus 로고
    • In vitro and in vivo cytotoxic activities of recombinant immunotoxin 8H9(Fv)-PE38 against breast cancer, osteosarcoma, and neuroblastoma
    • Onda, M., Q. C. Wang, H. F. Guo, N. K. Cheung, and I. Pastan. 2004. In vitro and in vivo cytotoxic activities of recombinant immunotoxin 8H9(Fv)-PE38 against breast cancer, osteosarcoma, and neuroblastoma. Cancer Res. 64: 1419-1424.
    • (2004) Cancer Res , vol.64 , pp. 1419-1424
    • Onda, M.1    Wang, Q.C.2    Guo, H.F.3    Cheung, N.K.4    Pastan, I.5
  • 15
    • 0026318613 scopus 로고
    • Anti-tumor activities of immunotoxins made of monoclonal antibody B3 and various forms of Pseudomonas exotoxin
    • Pai, L. H., J. K. Batra, D. J. FitzGerald, M. C. Willingham, and I. Pastan. 1991. Anti-tumor activities of immunotoxins made of monoclonal antibody B3 and various forms of Pseudomonas exotoxin. Proc. Natl. Acad. Sci. USA 88: 3358-3362.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 3358-3362
    • Pai, L.H.1    Batra, J.K.2    FitzGerald, D.J.3    Willingham, M.C.4    Pastan, I.5
  • 16
    • 0035981227 scopus 로고    scopus 로고
    • A divalent recombinant immunotoxin formed by a disulfide bond between the extension peptide chains
    • Park, J. H., H. W. Kwon, H. K. Chung, I. H. Kim, K. Ahn, E. J. Choi, I. Pastan, and M. Choe. 2001. A divalent recombinant immunotoxin formed by a disulfide bond between the extension peptide chains. Mol. Cells 12: 398-402.
    • (2001) Mol. Cells , vol.12 , pp. 398-402
    • Park, J.H.1    Kwon, H.W.2    Chung, H.K.3    Kim, I.H.4    Ahn, K.5    Choi, E.J.6    Pastan, I.7    Choe, M.8
  • 17
    • 0025826197 scopus 로고
    • Characterization of monoclonal antibodies B1 and B3 that react with mucinous adenocarcinomas
    • Pastan, I., E. T. Lovelace, M. G. Gallo, A. V. Rutherford, J. L. Magnani, and M. C. Willingham. 1991. Characterization of monoclonal antibodies B1 and B3 that react with mucinous adenocarcinomas. Cancer Res. 51: 3781-3787.
    • (1991) Cancer Res , vol.51 , pp. 3781-3787
    • Pastan, I.1    Lovelace, E.T.2    Gallo, M.G.3    Rutherford, A.V.4    Magnani, J.L.5    Willingham, M.C.6
  • 18
    • 0028285899 scopus 로고
    • Improved binding and antitumor activity of a recombinant anti-erbB2 immunotoxin by disulfide stabilization of the Fv fragment
    • Reiter, Y., U. Brinkmann, S. H. Jung, B. Lee, P. G. Kasprzyk, C. R. King, and I. Pastan. 1994. Improved binding and antitumor activity of a recombinant anti-erbB2 immunotoxin by disulfide stabilization of the Fv fragment. J. Biol. Chem. 269: 18327-18331.
    • (1994) J. Biol. Chem , vol.269 , pp. 18327-18331
    • Reiter, Y.1    Brinkmann, U.2    Jung, S.H.3    Lee, B.4    Kasprzyk, P.G.5    King, C.R.6    Pastan, I.7
  • 19
    • 0028275863 scopus 로고
    • Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment
    • Reiter, Y., L. H. Pai, U. Brinkmann, Q. C. Wang, and I. Pastan. 1994. Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment. Cancer Res. 54: 2714-2718.
    • (1994) Cancer Res , vol.54 , pp. 2714-2718
    • Reiter, Y.1    Pai, L.H.2    Brinkmann, U.3    Wang, Q.C.4    Pastan, I.5
  • 20
    • 0028330865 scopus 로고
    • Cytotoxicity of recombinant Fab and Fv immunotoxins on adult T-cell leukemia lymph node and blood cells in the presence of soluble interleukin-2 receptor
    • Saito, T., R. J. Kreitman, S. Hanada, T. Makino, A. Utsunomiya, T. Sumizawa, et al. 1994. Cytotoxicity of recombinant Fab and Fv immunotoxins on adult T-cell leukemia lymph node and blood cells in the presence of soluble interleukin-2 receptor. Cancer Res. 54: 1059-1064.
    • (1994) Cancer Res , vol.54 , pp. 1059-1064
    • Saito, T.1    Kreitman, R.J.2    Hanada, S.3    Makino, T.4    Utsunomiya, A.5    Sumizawa, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.