No relationship exist between PBP 2a amounts expressed in different MRSA strains obtained clinically and their β-1actam MIC values

Journal of Medical Investigation

Volumn 55, Issue 3-4, 2008, Pages 246-253

  Parvez, Md Anowar Khasru ^a   Shibata, Hirofumi ^a   Nakano, Tatsuro ^a   Niimi, Shingo ^b   Fujii, Nobuo ^c   Arakaki, Naokatu ^a   Higuti, Tomihiko ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^c TOKUSHIMA BUNRI UNIVERSITY   (Japan)

Author keywords

Methicillin resistant Staphylococcus aureus (MRSA); Penicillin binding protein (PBP) 2a; lactam MIC values

Indexed keywords

BETA LACTAM ANTIBIOTIC; CEFAPIRIN; CEFOTAXIME; MEMBRANE PROTEIN; METICILLIN; OXACILLIN; PENICILLIN BINDING PROTEIN 2A; PROTEIN ANTIBODY; BACTERIAL PROTEIN; BETA LACTAM; MECA PROTEIN, STAPHYLOCOCCUS AUREUS; PENICILLIN BINDING PROTEIN; UNCLASSIFIED DRUG;

AGAR DILUTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; IMMUNOBLOTTING; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN SENSITIVE STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN EXPRESSION; STAPHYLOCOCCUS AUREUS; DRUG EFFECT; GENETICS; HUMAN; IN VITRO STUDY; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY; PENICILLIN RESISTANCE; SPECIES DIFFERENCE; STAPHYLOCOCCUS INFECTION;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS SUBSP. AUREUS COL;

BACTERIAL PROTEINS; BETA-LACTAMS; HUMANS; IMMUNOBLOTTING; METHICILLIN RESISTANCE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; PENICILLIN-BINDING PROTEINS; SPECIES SPECIFICITY; STAPHYLOCOCCAL INFECTIONS;

EID: 56749154034     PISSN: 13431420     EISSN: None     Source Type: Journal    
DOI: 10.2152/jmi.55.246     Document Type: Article

References (35)

1. Diekema DJ, Pfaller MA, Schmitz FJ, Smayevsky J, Bell J, Jones RN, Beach M, SENTRY Participants Group: Survey of Infections Due to Staphylococcus Species: Frequency of Occurrence and Antimicrobial Susceptibility of Isolates Collected in the United States, Canada, Latin America, Europe, and the Western Pacific Region for the SENTRY Antimicrobial Surveillance Program, 1997-1999. Clin Infect Dis 32: S114-S132, 2001
2. Akcam FZ, Tinaz GB, Kaya O, Tigli A, Ture E, Hosoglu S: Evaluation of methicillin resistance by cefoxitin disk diffusion and PBP 2a latex agglutination test in mecA-positive Staphylococcus aureus, and comparison of mecA with femA, femB , femX positivities. Microbiol Res. doi: 10.1016/j.micres.2007.02.012. (Article in Press, 2007)
3. Song MD, Wachi M, Doi D, Ishino F, Matsuhashi M: Evolution of an inducible penicillin-target protein in methicillin-resistant Staphylococcus aureus by gene fusion. FEBS Lett 221: 167-171, 1987
4. Wu SW, de Lencastre H, Tomasz A: Recruitment of the mecA gene homologue of Staphylococcus sciuri into a resistance determinant and expression of the resistant phenotype in Staphylococcus aureus. J Bacteriol 183: 2417-2424, 2001
5. Wu SW, de Lencastre H, Tomasz A: Expression of high-level methicillin resistance in Staphylococcus aureus from the Staphylococcus sciuri mec A homologue: role of mutation(s) in the genetic background and in the coding region of mec A. Microb Drug Resist 11: 215-224, 2005
6. Fuda C, Suvorov M, Shi Q, Hesek D, Lee M, Mobashery S: Shared functional attributes between the mecA gene product of Staphylococcus sciuri and penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus. Biochemistry 46: 8050-8057, 2007
7. Goldstein F, Perutka J, Cuirolo A, Plata K, Faccone D, Morris J, Sournia A, Kitzis MD, Ly A, Archer G, Rosato AE: Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain. Antimicrob Agents Chemother 51: 2514-2522, 2007
8. Goffin C, Ghuysen JM: Multimodular penicillin-binding proteins: an enigmatic family of orthologs and paralogs. Microbiol Mol Biol Rev 62: 1079-1093, 1998
9. Hartman BJ, Tomasz A: Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus. J Bacteriol 158: 513-516, 1984
10. Reynolds PE, Brown DF: Penicillin-binding proteins of beta-lactam-resistant strains of Staphylococcus aureus. Effect of growth conditions. FEBS Lett 192: 28-32, 1985
11. Palavecino E: Clinical, epidemiological, and laboratory aspects of methicillin-resistant Staphylococcus aureus (MRSA) infections. Methods Mol Biol 391: 1-11, 2007
12. Shibata H, Shirakata C, Kawasaki H, Sato Y, Kuwahara T, Ohnishi Y, Arakaki N, Higuti T: Flavone markedly affects phenotypic expression of β-lactam resistance in methicillin-resistant Staphylococcus aureus strains isolated clinically. Biol Pharm Bull 26: 1478-1483, 2003
13. Tomasz A: "The staphylococcal cell wall". In: Fischetti VA, Novick RP, Ferretti JJ, Portnoy DA, Rood JI, eds. Gram-positive pathogens. American Society for Microbiology, Washington DC, 2000, pp. 463-470
14. Hartman BJ, Tomasz A: Expression of methicillin resistance in heterogeneous strains of Staphylococcus aureus. Antimicrob Agents Chemother 29:85-92, 1986
15. Sato Y, Shibata H, Arakaki N, Higuti T: 6,7-Dihydroxyflavone dramatically intensifies the susceptibility of methicillin-resistant or sensitive Staphylococcus aureus to β-lactams. Antimicrob Agents Chemother 48 :1357-1360, 2004
16. Sekiguchi K, Saito M, Yajima R: Detection of methicillin-resistant Staphylococcus aureus (MRSA) with antibodies against synthetic peptides derived from penicillin-binding protein 2′. Microbiol Immunol 39: 545-550, 1995
17. Higuti T, Negama T, Takigawa M, Uchida J, Yamane T, Asai T, Tani I, Oeda K, Shimizu M, Nakamura K, Ohkawa H: A hydrophobic protein, chargerin II, purified from rat liver mitochondria is encoded in the unidentified reading frame A6L of mitochondrial DNA. J Biol Chem 263: 6772-6776, 1988
18. Oliver B, Wolfgang B, Gerhard P: Regulation of p-lactamase synthesis as a novel site of action for suppression of methicillin resistance in Staphylococcus aureus. Zentbl Bakteriol 285: 413-430, 1997
19. Ryffel C, Strassle A, Kayser FH, Berger-Bächi B: Mechanisms of heteroresistance in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 38: 724-728, 1994
20. Kondo N, Kuwahara-arai K, Kurodamurakami H, Tateda-suzuki E, Hiramatsu K: Eagle-type methicillin resistance: new phenotype of high methicillin resistance under mec regulator gene control. Antimicrob Agents Chemother 45: 815-824, 2001
21. Tomasz A, Nachman S, Leaf H: Stable classes of phenotypic expression in methicillin-resistant clinical isolates of staphylococci. Antimicrob Agents Chemother 35:124-129, 1991
22. Araj GF, Talhouk RS, Simaan CJ, Maasad MJ: Discrepancies between mecA PCR and conventional tests used for detection of methicillin resistant Staphylococcus aureus. Int J Antimicrob Agents 11: 47-52, 1999
23. Kuroda M, Ohta T, Uchiyama I, Baba T, Yuzawa H, Kobayashi I, Cui L, Oguchi A, Aoki K, Nagai Y: Whole genome sequencing of methicillin-resistant Staphylococcus aureus. Lancet 357: 1225-1240, 2001
24. Ohta T, Hirakawa H, Morikawa K, Maruyama A, Inose Y, Yamashita A, Oshima K, Kuroda M, Hattori M, Hiramatsu K, Kuhara S, Hayashi H: Nucleotide substitutions in Staphylococcus aureus strains, Mu50, Mu3, and N315. DNA Res 29: 51-56, 2004
25. Hiramatsu K: Molecular evolution of MRSA. Microbiol Immunol 39: 531-543, 1995
26. Ryffel C, Kayser FH, Berger-Bächi B: Correlation between regulation of mecA transcription and expression of methicillin resistance in staphylococci. Antimicrob Agents Chemother 36: 25-31, 1992
27. Petinaki E, Arvaniti A, Bartzavali C, Dimitracopoulos G, Spiliopoulou I: Presence of mecA genes and overproduction of betalactamase in the expression of low-level methicillin resistance among staphylococci. Chemother 48: 174-181, 2002
28. McDougal LK, Thornsberry C: The role of beta-lactamase in staphylococcal resistance to penicillinase-resistant penicillins and cephalosporins. J Clin Microbiol 23: 832-839, 1986
29. Murakami K, Nomura K, Doi M, Yoshida T: Production of low-affinity penicillin-binding protein by low and high-resistance groups of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 31: 1307-1311, 1987
30. Hanaki H, Kuwahara-Arai K, Boyle-Vavra S, Daum RS, Labischinski H, Hiramatsu K: Activated cell-wall synthesis is associated with vancomycin resistance in methicillin-resistant Staphylococcus aureus clinical strains Mu3 and Mu50. J Antimicrob Chemother 42: 199-209, 1998
31. Cui L, Tominaga E, Neoh HM, Hiramatsu K: Correlation between reduced daptomycin susceptibility and vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. Antimicrob Agents Chemother 50: 1079-1082, 2006
32. Cui L, Ma X, Sato K, Okuma K, Tenover FC, Mamizuka EM, Gemmell CG, Kim MN, Ploy M, El-Solh CN, Ferraz V, Hiramatsu K: Cell wall thickening is a common feature of vancomycin resistance in Staphylococcus aureus. J Clin Microbiol 41: 5-14, 2003
33. Boyle-Vavra S, Yin S, Daum RS: The VraS/VraR two-component regulatory system required for oxacillin resistance in community-acquired methicillin-resistant Staphylococcus aureus. FEMS Microbiol Lett 262: 163-171, 2006
34. Berger-Bächi B, Rohrer S: Factors influencing methicillin resistance in staphylococci. Arch Microbiol 178: 165-171, 2002
35. Sato Y, Shibata H, Arai T, Yamamoto A, Okimura Y, Arakaki N, Higuti T: Variation in synergistic activity by flavone and its related compounds on the increased susceptibility of various strains of methicillin-resistant Staphylococcus aureus to β-lactam antibiotics. Int J Antimicrob Agents 24: 28-35, 2004