Antithrombotic therapy influences location, enlargement, and mortality from intracerebral hemorrhage: The Bleeding with Antithrombotic Therapy (BAT) study

Cerebrovascular Diseases

Volumn 27, Issue 2, 2009, Pages 151-159

  Toyoda, Kazunori ^a   Yasaka, Masahiro ^b   Nagata, Ken ^c   Nagao, Takehiko ^d   Gotoh, Jun ^f   Sakamoto, Tomohiro ^g   Uchiyama, Shinichiro ^e   Minematsu, Kazuo ^a  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b NATIONAL HOSPITAL ORGANIZATION   (Japan)

^c RESEARCH INSTITUTE FOR BRAIN AND BLOOD VESSELS AKITA   (Japan)

^d Department of Dentistry Oral surgery   (Japan)

^e TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^f SAITAMA NATIONAL HOSPITAL   (Japan)

^g KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Anticoagulation; Antiplatelet agent; Aspirin; Intracerebral hemorrhage; Stroke outcome; Warfarin

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; CILOSTAZOL; CLOPIDOGREL; FRESH FROZEN PLASMA; HEMOSTATIC AGENT; SARPOGRELATE; TICLOPIDINE; VITAMIN K GROUP; WARFARIN;

AGED; ARTICLE; BASAL GANGLION HEMORRHAGE; BRAIN HEMATOMA; BRAIN HEMORRHAGE; CEREBELLUM HEMORRHAGE; CEREBROVASCULAR ACCIDENT; COMPUTER ASSISTED TOMOGRAPHY; CONTROL GROUP; CONTROLLED STUDY; DRUG FATALITY; FEMALE; GLUCOSE BLOOD LEVEL; HOSPITAL PATIENT; HUMAN; HYPERCHOLESTEROLEMIA; JAPANESE; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SIDE EFFECT;

ADMINISTRATION, ORAL; AGED; CEREBRAL HEMORRHAGE; DRUG THERAPY, COMBINATION; FEMALE; FIBRINOLYTIC AGENTS; HEMATOMA; HUMANS; JAPAN; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PLATELET AGGREGATION INHIBITORS; RETROSPECTIVE STUDIES; RISK FACTORS; TREATMENT OUTCOME; WARFARIN;

EID: 56749151360     PISSN: 10159770     EISSN: None     Source Type: Journal    
DOI: 10.1159/000177924     Document Type: Article

References (39)

1. Hart RG, Boop BS, Anderson DC: Oral anticoagulants and intracranial hemorrhage: facts and hypotheses. Stroke 1995;26:1471-1477.
2. Rosand J, Eckman MH, Knudsen KA, Singer DE, Greenberg SM: The effect of warfarin and intensity of anticoagulation on outcome of intracerebral hemorrhage. Arch Intern Med 2004;164:880-884.
3. Radberg JA, Olsson JE, Radberg CT: Prognostic parameters in spontaneous intracerebral hematomas with special reference to anticoagulant treatment. Stroke 1991;22:571-576.
4. Wong KS: Risk factors for early death in acute ischemic stroke and intracerebral hemorrhage: a prospective hospital-based study in Asia. Asian Acute Stroke Advisory Panel. Stroke 1999;30:2326-2330.
5. Nilsson OG, Lindgren A, Brandt L, Säveland H: Prediction of death in patients with primary intracerebral hemorrhage: a prospective study of a defined population. J Neurosurg 2002;97:531-536.
6. Flibotte JJ, Hagan N, O'Donnell J, Greenberg SM, Rosand J: Warfarin, hematoma expansion, and outcome of intracerebral hemorrhage. Neurology 2004;63:1059-1064.
7. Roquer J, Rodriguez Campello A, Gomis M, Ois A, Puente V, Munteis E: Previous antiplatelet therapy is an independent predictor of 30-day mortality after spontaneous supratentorial intracerebral hemorrhage. J Neurol 2005;252:412-416.
8. Saloheimo P, Ahonen M, Juvela S, Pyhtinen J, Savolainen ER, Hillbom M: Regular aspirin-use preceding the onset of primary intracerebral hemorrhage is an independent predictor for death. Stroke 2006;37:129-133.
9. Broderick JP, Diringer MN, Hill MD, Brun NC, Mayer SA, Steiner T, Skolnick BE, Davis SM; Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators: determinants of intracerebral hemorrhage growth: an exploratory analysis. Stroke 2007;38:1072-1075.
10. Baldi G, Altomonte F, Altomonte M, Ghirarduzzi A, Brusasco C, Parodi RC, Ricciardi A, Remollino V, Spisni V, Saporito A, Caiazza A, Musso G, Cervellin G, Lamberti S, Buzzalino M, De Giorgi F, Del Prato C, Golinelli MP, Gai V, Monsù R, Gioffre M, Giovanardi D, Cattaneo S, Frumento F, Caporrella A, Re G, De Iaco F, Bologna G, Nocenti F, Lorenzi C, Zoratti R, Sciolla A, Tiscione V, Pastorello M, Vandelli A, Villa A, Zanna M, De Palma A, Iorio A: Intracranial haemorrhage in patients on antithrombotics: clinical presentation and determinants of outcome in a prospective multicentric study in Italian emergency departments. Cerebrovasc Dis 2006;22:286-293.
11. Shen AY, Yao JF, Brar SS, Jorgensen MB, Chen W: Racial/ethnic differences in the risk of intracranial hemorrhage among patients with atrial fibrillation. J Am Coll Cardiol 2007;50:309-315.
12. Kubo M, Kiyohara Y, Kato I, Tanizaki Y, Arima H, Tanaka K, Nakamura H, Okubo K, Iida M: Trends in the incidence, mortality, and survival rate of cardiovascular disease in a Japanese community: the Hisayama study. Stroke 2003;34:2349-2354.
13. Toyoda K, Okada Y, Minematsu K, Kamouchi M, Fujimoto S, Ibayashi S, Inoue T: Antiplatelet therapy contributes to acute deterioration of intracerebral hemorrhage. Neurology 2005;65:1000-1004.
14. Toyoda K, Yasaka M, Iwade K, Nagata K, Koretsune Y, Sakamoto T, Uchiyama S, Gotoh J, Nagao T, Yamamoto M, Takahashi JC, Minematsu K; Bleeding with Antithrombotic Therapy (BAT) Study Group: Dual antithrombotic therapy increases severe bleeding events in patients with stroke and cardiovascular disease: a prospective multicenter observational study. Stroke 2008;39:1740-1745.
15. Kothari RU, Brott T, Broderick JP, Barsan WG, Sauerbeck LR, Zuccarello M, Khoury J: The ABCs of measuring intracerebral hemorrhage volumes. Stroke 1996;27:1304-1305.
16. Brott T, Broderick J, Kothari R, Barsan W, Tomsick T, Sauerbeck L, Spilker J, Duldner J, Khoury J: Early hemorrhage growth in patients with intracerebral hemorrhage. Stroke 1997;28:1-5.
17. Yasaka M, Minematsu K, Naritomi H, Sakata T, Yamaguchi T: Predisposing factors for enlargement of intracerebral hemorrhage in patients treated with warfarin. Thromb Haemost 2003;89:278-283.
18. Kazui S, Minematsu K, Yamamoto H, Sawada T, Yamaguchi T: Predisposing factors to enlargement of spontaneous intracerebral hematoma. Stroke 1997;28:2370-2375.
19. Nilsson OG, Lindgren A, Ståhl N, Brandt L, Säveland H: Incidence of intracerebral and subarachnoid haemorrhage in southern Sweden. J Neurol Neurosurg Psychiatry 2000;69:601-607.
20. Woo D, Sauerbeck LR, Kissela BM, Khoury JC, Szaflarski JP, Gebel J, Shukla R, Pancioli AM, Jauch EC, Menon AG, Deka R, Carrozzella JA, Moomaw CJ, Fontaine RN, Broderick JP: Genetic and environmental risk factors for intracerebral hemorrhage: preliminary results of a population-based study. Stroke 2002;33:1190-1195.
21. Yamaguchi T: Optimal intensity of warfarin therapy for secondary prevention of stroke in patients with nonvalvular atrial fibrillation: a multicenter, prospective, randomized trial. Japanese Nonvalvular Atrial Fibrillation-Embolism Secondary Prevention Cooperative Study Group. Stroke 2000;31:817-821.
22. Yasaka M, Minematsu K, Yamaguchi T: Optimal intensity of international normalized ratio in warfarin therapy for secondary prevention of stroke in patients with non-valvular atrial fibrillation. Intern Med 2001;40:1183-1188.
23. Goldstein LB, Adams R, Alberts MJ, et al: Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group: the American Academy of Neurology affirms the value of this guideline. Stroke 2006;37:1583-1633.
24. Kase CS, Robinson RK, Stein RW, DeWitt LD, Hier DB, Harp DL, Williams JP, Caplan LR, Mohr JP: Anticoagulant-related intracerebral hemorrhage. Neurology 1985;35:943-948.
25. Warfarin versus aspirin for prevention of thromboembolism in atrial fibrillation: Stroke Prevention in Atrial Fibrillation II Study. Lancet 1994;343:687-691.
26. Franke CL, de Jonge J, van Swieten JC, Op de Coul AA, van Gijn J: Intracerebral hematomas during anticoagulant treatment. Stroke 1990;21:726-730.
27. Fredriksson K, Norrving B, Stromblad LG: Emergency reversal of anticoagulation after intracerebral hemorrhage. Stroke 1992;23:972-977.
28. Toyoda K, Okada Y, Ibayashi S, Inoue T, Yasumori K, Fukui D, Uwatoko T, Makihara N, Minematsu K: Antithrombotic therapy and predilection for cerebellar hemorrhage. Cerebrovasc Dis 2007;23:109-116.
29. Wong KS, Mok V, Lam WW, Kay R, Tang A, Chan YL, Woo J: Aspirin-associated intracerebral hemorrhage: clinical and radiologic features. Neurology 2000;54:2298-2301.
30. Lee SH, Kwon SJ, Kim KS, Yoon BW, Roh JK: Topographical distribution of pontocerebellar microbleeds. AJNR Am J Neuroradiol 2004;25:1337-1341.
31. Kazui S, Naritomi H, Yamamoto H, Sawada T, Yamaguchi T: Enlargement of spontaneous intracerebral hemorrhage: incidence and time course. Stroke 1996;27:1783-1787.
32. Fujii Y, Takeuchi S, Sasaki O, Minakawa T, Tanaka R: Multivariate analysis of predictors of hematoma enlargement in spontaneous intracerebral hemorrhage. Stroke 1998;29:1160-1166.
33. Rundek T, Sacco RL: Outcome following stroke; in Mohr JP, Choi DW, Grotta JC, Weir B, Wolf PA (eds): Stroke: Pathophysiology, Diagnosis, and Management, ed 4. Philadelphia, Churchill Livingstone, 2004, pp 35-57.
34. Broderick J, Connolly S, Feldmann E, Hanley D, Kase C, Krieger D, Mayberg M, Morgenstern L, Ogilvy CS, Vespa P, Zuccarello M: Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update: a guideline from the American Heart Association/American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Outcomes in Research Interdisciplinary Working Group. Stroke 2007;38:2001-2023.
35. Qureshi AI, Tuhrim S, Broderick JP, Batjer HH, Hondo H, Hanley DF: Spontaneous intracerebral hemorrhage. N Engl J Med 2001;344:1450-1460.
36. Foerch C, Sitzer M, Steinmetz H, Neumann-Haefelin T: Pretreatment with antiplatelet agents is not independently associated with unfavorable outcome in intracerebral hemorrhage. Stroke 2006;37:2165-2167.
37. Diener HC, Bogousslavsky J, Brass LM, Cimminiello C, Csiba L, Kaste M, Leys D, Matias-Guiu J, Rupprecht HJ; MATCH investigators: Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet 2004;364:331-337.
38. Bhatt DL, Fox KA, Hacke W, Berger PB, Black HR, Boden WE, Cacoub P, Cohen EA, Creager MA, Easton JD, Flather MD, Haffner SM, Hamm CW, Hankey GJ, Johnston SC, Mak KH, Mas JL, Montalescot G, Pearson TA, Steg PG, Steinhubl SR, Weber MA, Brennan DM, Fabry-Ribaudo L, Booth J, Topol EJ; CHARISMA Investigators: Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med 2006;354:1706-1717.
39. Dentali F, Douketis JD, Lim W, Crowther M: Combined aspirin-oral anticoagulant therapy compared with oral anticoagulant therapy alone among patients at risk for cardiovascular disease: a meta-analysis of randomized trials. Arch Intern Med 2007;167:117-124.