Biophysical analyses of human resistin: Oligomer formation suggests novel biological function

Biochemistry

Volumn 47, Issue 47, 2008, Pages 12457-12466

  Aruna, Battu ^a   Islam, Asimul ^b   Ghosh, Sudip ^a   Singh, Anil K ^c   Vijayalakshmi, Malladi ^a   Ahmad, Faizan ^b   Ehtesham, Nasreen Z ^a  

^a NATIONAL INSTITUTE OF NUTRITION   (India)

^b JAMIA MILLIA ISLAMIA CENTRAL UNIVERSITY   (India)

^c CENTRE FOR DNA FINGERPRINTING AND DIAGNOSTICS   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; COLLOIDS; CONCENTRATION (PROCESS); CONFORMATIONS; FLOW INTERACTIONS; GELATION; HYDROPHOBICITY; METABOLISM; MONOMERS; OLIGOMERIZATION; OLIGOMERS; POROUS MATERIALS; PROBABILITY DENSITY FUNCTION; SODIUM CHLORIDE; UREA;

BIOLOGICAL FUNCTIONS; BIOPHYSICAL ANALYSES; CONFORMATIONAL CHANGES; DISULFIDE LINKAGES; GEL FILTRATION ANALYSIS; HYDROPHOBIC INTERACTIONS; IN VITRO; IONIC INTERACTIONS; PATHOLOGICAL CONDITIONS; PROINFLAMMATORY CYTOKINES; PROTEIN CONCENTRATIONS; RESISTIN; SECONDARY STRUCTURES; SHEET FORMS; STRUCTURAL CONFORMATIONS;

POLYMERS;

FLUORIDE SODIUM; MONOMER; OLIGOMER; RESISTIN; SODIUM CHLORIDE; UREA;

ARTICLE; CHEMICAL INTERACTION; CHROMATOGRAPHY; DENATURATION; GEL FILTRATION; HUMAN; HUMAN CELL; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN CONTENT; PROTEIN STRUCTURE;

HUMANS; HYDROPHOBICITY; PROTEIN DENATURATION; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE, QUATERNARY; RESISTIN; TEMPERATURE;

MUS;

EID: 56749128040     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi801266k     Document Type: Article

References (30)

1. Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., and Lazar, M. A. (2001) The hormone resistin links obesity to diabetes. Nature 409, 307-312.
2. Flier, J. S. (2001) Diabetes. The missing link with obesity? Nature 409, 292-293.
3. Ehtesham, N. Z. (2001) Molecular link between diabetes and obesity: The resistin story. Curr. Sci. 80, 1369-1371.
4. Way, J. M., Gorgun, C. Z., Tong, Q., Uysal, K. T., Brown, K. K., Harrington, W. W., Jr., Willson, T. M., Kliewer, S. A., and Hotamisligil, G. S. (2001) Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists. J. Biol. Chem. 276, 25651-25653.
5. Nagaev, I., and Smith, U. (2001) Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle. Biochem. Biophys. Res. Commun. 285, 561-564.
6. Janke, J., Engeli, S., Gorzelniak, K., Luft, F. C., and Sharma, A. M. (2002) Resistin gene expression in human adipocytes is not related to insulin resistance. Obes. Res. 10, 1-5.
7. McTernan, C. L., McTernan, P. G., Harte, A. L., Levick, P. L., Barnett, A. H., and Kumar, S. (2002) Resistin, central obesity, and type 2 diabetes. Lancet 359, 46-47.
8. Azuma, K., Katsukawa, F., Oguchi, S., Murata, M., Yamazaki, H., Shimada, A., and Saruta, T. (2003) Correlation between serum resistin level and adiposity in obese individuals. Obes. Res. 11, 997-1001.
9. Ghosh, S., Singh, A. K., Aruna, B., Mukhopadhyay, S., and Ehtesham, N. Z. (2003) The genomic organization of mouse resistin reveals major differences from the human resistin: functional implications. Gene 305, 27-34.
10. Patel, L., Buckels, A. C., Kinghorn, I. J., Murdock, P. R., Holbrook, J. D., Plumpton, C., Macphee, C. H., and Smith, S. A. (2003) Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators. Biochem. Biophys. Res. Commun. 300, 472-476.
11. Kaser, S., Kaser, A., Sandhofer, A., Ebenbichler, C. F., Tilg, H., and Patsch, J. R. (2003) Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro. Biochem. Biophys. Res. Commun. 309, 286-290.
12. Lehrke, M., Reilly, M. P., Millington, S. C., Iqbal, N., Rader, D. J., and Lazar, M. A. (2004) An inflammatory cascade leading to hyperresistinemia in humans. PLoS Med. 1, e45.
13. Bokarewa, M., Nagaev, I., Dahlberg, L., Smith, U., and Tarkowski, A. (2005) Resistin, an adipokine with potent proinflammatory properties. J. Immunol. 174, 5789-5795.
14. Reilly, M. P., Lehrke, M., Wolfe, M. L., Rohatgi, A., Lazar, M. A., and Rader, D. J. (2005) Resistin is an inflammatory marker of atherosclerosis in humans. Circulation 111, 932-939.
15. Silswal, N., Singh, A. K., Aruna, B., Mukhopadhyay, S., Ghosh, S., and Ehtesham, N. Z. (2005) Human resistin stimulates the proinflammatory cytokines TNF-α and TL-12 in macrophages by NF-κB dependent pathway. Biochem. Biophys. Res. Commun. 334, 1092-1101.
16. Pang, S. S., and Le, Y. Y. (2006) Role of resistin in inflammation and inflammation-related diseases. Cell. Mol. Immunol. 3, 29-34.
17. Osawa, H., Onuma, H., Murakami, A., Ochi, M., Nishimiya, T., Kato, K., Shimizu, I., Fujii, Y., Ohashi, J., and Makino, H. (2002) Systematic search for single nucleotide polymorphisms in the resistin gene: the absence of evidence for the association of three identified single nucleotide polymorphisms with Japanese type 2 diabetes. Diabetes 51, 863-866.
18. Smith, S. R., Bai, F., Charbonneau, C., Janderova, L., and Argyropoulos, G. (2003) A promoter genotype and oxidative stress potentially link resistin to human insulin resistance. Diabetes 52, 1611-1618.
19. Ochi, M., Osawa, H., Onuma, H., Murakami, A., Nishimiya, T., Shimada, F., Kato, K., Shimizu, I., Shishino, K., Murase, M., Fujii, Y., Ohashi, J., and Makino, H. (2003) The absence of evidence for major effects of the frequent SNP + 299G → A in the resistin gene on susceptibility to insulin resistance syndrome associated with Japanese type 2 diabetes. Diabetes Res. Clin. Pract. 61, 191-198.
20. Osawa, H., Yamada, K., Onuma, H., Murakami, A., Ochi, M., Kawata, H., Nishimiya, T., Niiya, T., Shimizu, I., Nishida, W., Hashiramoto, M., Kanatsuka, A., Fujii, Y., Ohashi, J., and Makino, H. (2004) The G/G genotype of a resistin single-nucleotide polymorphism at-420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3. Am. J. Hum. Genet. 75, 678-686.
21. Patel, S. D., Rajala, M. W., Rossetti, L., Scherer, P. E., and Shapiro, L. (2004) Disulfide-dependent multimeric assembly of resistin family hormones. Science 304, 1154-1158.
22. Aruna, B., Ghosh, S., Singh, A, K., Mande, S. C., Srinivas, V., Chauhan, R., and Ehtesham, N. Z. (2003) Human recombinant resistin protein displays a tendency to aggregate by forming intermolecular disulfide linkages. Biochemistry 42, 10554-10559.
23. Gerber, M., Boettner, A., Seidel, B., Lammert, A., Bar, J., Schuster, E., Thiery, J., Kiess, W., and Kratzsch, J. (2005) Serum resistin levels of obese and lean children and adolescents: biochemical analysis and clinical relevance. J. Clin. Endocrinol. Metab. 90, 4503-4509.
24. Raghu, P., Ghosh, S., Kanukolanu, S., Haseeb, A., Aruna, B., and Ehtesham, N. Z. (2004) Dimerization of human recombinant resistin involves covalent and noncovalent interactions. Biochem. Biophys. Res. Commun. 313, 642-646.
25. Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., and Gray, T. (1995) How to measure and predict the molar absorption coefficient of a protein. Protein Sci. 4, 2411-2423.
26. Schmid, F. X. (1990) Spectral methods of characterizing protein conformation and conformational changes, in Protein Structure: A practical approach (Creighton, T. E., Ed.) IRL Press, Oxford University Press, New York.
27. Pan, K. M., Baldwin, M., Nguyen, J., Gasset, M., Serban, A., Groth, D., Mehlhorn, I., Huang, Z., Fletterick, R. J., Cohen, F. E., and Prusiner, S. B. (1993) Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion protein, Proc. Natl. Acad. Sci. U.S.A. 90, 10962-10966.
28. Pajvani, U. B., Du, X., Combs, T. P., Berg, A. H., Rajala, M. W., Schulthess, T., Engel, J., Brownlee, M., and Scherer, P. E. (2003) Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin: Implications for metabolic regulation and bioactivity. J. Biol. Chem. 278, 9073-9085.
29. Sah, N. K., Taneja, T. K., Pathak, N., Begum, R., Athar, M., and Hasnain, S. E. (1999) The baculovirus antiapoptotic p35 gene also functions via an oxidant-dependent pathway. Proc. Natl. Acad. Sci. U.S.A. 96, 4838-4843.
30. Hampton, E. N., Knuth, M. W., Li, J., Harris, J. L., Lesley, S. A., and Spraggon, G. (2007) The self-inhibited structure of full-length PCSK9 at 1.9 Å reveals structural homology with resistin within the C-terminal domain. Proc. Natl. Acad. Sci. U.S.A. 104, 14604-14609.