Antithyroid drug carbimazole and its analogues: Synthesis and inhibition of peroxidase-catalyzed iodination of L-tyrosine

Journal of Medicinal Chemistry

Volumn 51, Issue 22, 2008, Pages 7313-7317

  Das, Debasis ^a   Roy, Gouriprasanna ^a   Mugesh, Govindasamy ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOLYTE; ANTITHYROID AGENT; CARBIMAZOLE; DISULFIDE; PEROXIDASE; SELENIUM DERIVATIVE; THIAMAZOLE; TYROSINE;

ARTICLE; CATALYSIS; DRUG ACTIVITY; DRUG DESIGN; DRUG OXIDATION; DRUG SYNTHESIS; ENZYME INHIBITION; HYPERTHYROIDISM; IODINATION; ONE POT SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ANTITHYROID AGENTS; CARBIMAZOLE; CATALYSIS; COMPUTER SIMULATION; HALOGENATION; MOLECULAR STRUCTURE; PEROXIDASE; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE;

EID: 56749107425     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800894m     Document Type: Article

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35. The hydrolysis of N-C bond in assay mixture was confirmed by HPLC analysis. The initial rates for the hydrolysis of N-C bond in various thiones/selones are given in Supporting Information, (Page S18).