Cellular mechanism of decreased bone in Brtl mouse model of OI: Imbalance of decreased osteoblast function and increased osteoclasts and their precursors

Journal of Bone and Mineral Research

Volumn 23, Issue 12, 2008, Pages 1983-1994

  Uveges, Thomas E ^a,b   Collin Osdoby, Patricia ^c   Cabral, Wayne A ^a   Ledgard, Felicia ^d   Goldberg, Leah ^c   Bergwitz, Clemens ^a,e   Forlino, Antonella ^a,f   Osdoby, Philip ^c   Gronowicz, Gloria A ^d   Marini, Joan C ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b TREVIGEN INC   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f UNIVERSITY OF PAVIA   (Italy)

Author keywords

Brtl mouse; Histomorphometry; Osteoclast; Rankl osteoprotegerin; Type i collagen

Indexed keywords

OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE STRUCTURE; BRTL MOUSE; C57BL 6 MOUSE; CELL ACTIVITY; CELL COUNT; CELL CULTURE; CELL FUNCTION; COLONY FORMING UNIT; CORTICAL BONE; GEOMETRY; GUINEA PIG; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOGENESIS IMPERFECTA; PROTEIN EXPRESSION; PUBERTY; REAL TIME POLYMERASE CHAIN REACTION; TRABECULAR BONE; WILD TYPE;

AMINO ACIDS; ANIMALS; BONE AND BONES; BONE MARROW CELLS; DISEASE MODELS, ANIMAL; FIBROBLASTS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OSTEOBLASTS; OSTEOCLASTS; OSTEOGENESIS IMPERFECTA; RANK LIGAND; STEM CELLS;

EID: 56749095463     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.080804     Document Type: Article

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