Another new "super muscle stem cell" leaves unaddressed the real problems of cell therapy for Duchenne muscular dystrophy

Molecular Therapy

Volumn 16, Issue 12, 2008, Pages 1907-1909

  Tremblay, Jacques P ^a   Skuk, Daniel ^a  

^a Université Laval   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 1; BETA1 INTEGRIN; CD11B ANTIGEN; CD45 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; DYSTROPHIN; IMMUNOSUPPRESSIVE AGENT;

CELL DIFFERENTIATION; CELL EXPANSION; CELL PROLIFERATION; CELL REGENERATION; CLINICAL TRIAL; DUCHENNE MUSCULAR DYSTROPHY; ENGRAFTMENT; GRAFT REJECTION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; MUSCLE DEVELOPMENT; MUSCLE REGENERATION; MUSCLE STRENGTH; MYOBLAST; NONHUMAN; NOTE; PROTEIN EXPRESSION; SKELETAL MUSCLE SATELLITE CELL; STEM CELL TRANSPLANTATION; THERAPY EFFECT;

EID: 56749092006     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2008.243     Document Type: Note

References (18)

1. Cerletti M, Jurga S, Witczak CA, Hirshman MF, Shadrach JL, Goodyear LJ et al. (2008). Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles. Cell 134: 37-47.
2. Sacco A, Doyonnas R, Kraft P, Vitorovic S and Blau HM (2008). Self-renewal and expansion of single transplanted muscle stem cells. Nature, published online 17 September 2008 (doi:10.1038/nature07384).
3. Montarras D, Morgan J, Collins C, Relaix F, Zaffran S, Cumano A et al. (2005). Direct isolation of satellite cells for skeletal muscle regeneration. Science 309: 2064-2067.
4. Beauchamp JR, Morgan JE, Pagel CN and Partridge TA (1999). Dynamics of myoblast transplantation reveal a discrete minority of precursors with stem cell-like properties as the myogenic source. J Cell Biol 144: 1113-1122.
5. Skuk D, Caron NJ, Goulet M, Roy B and Tremblay JP (2003). Resetting the problem of cell death following muscle-derived cell transplantation: detection, dynamics and mechanisms. J Neuropathol Exp Neurol 62 951-967.
6. Kinoshita I, Vilquin JT and Tremblay JP (1996). Mechanism of increasing dystrophin-positive myofibers by myoblast transplantation: Study using mdx/beta-galactosidase transgenic mice. Acta Neuropathol 91: 489-493.
7. Ehrhardt J, Brimah K, Adkin C, Partridge T and Morgan J (2007). Human muscle precursor cells give rise to functional satellite cells in vivo. Neuromuscul Disord 17: 631-638.
8. Gross JG and Morgan JE (1999). Muscle precursor cells injected into irradiated mdx mouse muscle persist after serial injury. Muscle Nerve 22: 174-185.
9. +) mouse. Gene Ther 8: 778-783.
10. Yao SN and Kurachi K (1993). Implanted myoblasts not only fuse with myofibers but also survive as muscle precursor cells. J Cell Sci 105: 957-963.
11. Skuk D, Goulet M, Roy B, Chapdelaine P, Bouchard JP, Roy R et al. (2006). Dystrophin expression in muscles of Duchenne muscular dystrophy patients after high-density injections of normal myogenic cells. J Neuropathol Exp Neurol 65: 371-386.
12. Webster C, Pavlath GK, Parks DR, Walsh FS and Blau HM (1988). Isolation of human myoblasts with the fluorescence-activated cell sorter. Exp Cell Res 174: 252-265.
13. Landon DN (1982). Skeletal muscle: Normal morphology, development and innervation. In: Mastaglia FL and Walton J (eds). Skeletal Muscle Pathology. Churchill Livingstone: Edinburgh, UK, pp 1-87.
14. Boulanger A, Asselin I, Roy R and Tremblay JP (1997). Role of non-major histocompatibility complex antigens in the rejection of transplanted myoblasts. Transplantation 63: 893-899.
15. Vilquin JT, Wagner E, Kinoshita I, Roy R and Tremblay JP (1995). Successful histocompatible myoblast transplantation in dystrophin-deficient mdx mouse despite the production of antibodies against dystrophin. J Cell Biol 131: 975-988.
16. van Deutekom JC, Janson AA, Ginjaar IB, Frankhuizen WS, Aartsma-Rus A, Bremmer-Bout M et al. (2007). Local dystrophin restoration with antisense oligo-nucleotide PRO051. N Engl J Med 357: 2677-2686.
17. Yokota T, Duddy W and Partridge T (2007). Optimizing exon skipping therapies for DMD. Acta Myol 26: 179-184.
18. Skuk D (2004). Myoblast transplantation for inherited myopathies: A clinical approach. Expert Opin Biol Ther 4: 1871-1885.