A functional single-nucleotide polymorphism in the CR1 promoter region contributes to protection against cerebral malaria

Journal of Infectious Diseases

Volumn 198, Issue 12, 2008, Pages 1880-1891

  Teeranaipong, Phairote ^a   Ohashi, Jun ^a,f   Patarapotikul, Jintana ^c   Kimura, Ryosuke ^a,b   Nuchnoi, Pornlada ^c,e   Hananantachai, Hathairad ^c   Naka, Izumi ^a   Putaporntip, Chaturong ^d   Jongwutiwes, Somchai ^d   Tokunaga, Katsushi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c MAHIDOL UNIVERSITY   (Thailand)

^d CHULALONGKORN UNIVERSITY   (Thailand)

^e NARESUAN UNIVERSITY   (Thailand)

^f UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3B RECEPTOR;

ADULT; ALLELE; ANTIGEN ANTIBODY COMPLEX; ARTICLE; BLOOD SAMPLING; BRAIN MALARIA; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FLOW CYTOMETRY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROMOTER REGION; PROPHYLAXIS; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; THAILAND;

GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINKAGE (GENETICS); MALARIA, CEREBRAL; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; RECEPTORS, COMPLEMENT 3B;

EID: 56749091497     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/593338     Document Type: Article

References (36)

1. Wong WW, Cahill JM, Rosen MD, et al. Structure of the human CR1 gene: molecular basis of the structural and quantitative polymorphisms and identification of a new CR1-like allele. J Exp Med 1989; 169:847-63.
2. Vik DP, Wong WW. Structure of the gene for the F allele of complement receptor type 1 and sequence of the coding region unique to the S allele. J Immunol 1993; 151:6214-24.
3. Krych-Goldberg M, Moulds JM, Atkinson JP. Human complement receptor type 1 (CR1) binds to a major malarial adhesin. Trends Mol Med 2002; 8:531-7.
4. Krych-Goldberg M, Atkinson JP. Structure-function relationships of complement receptor type 1. Immunol Rev 2001; 180:112-22.
5. Birmingham DJ, Hebert LA. CR1 and CR1-like: the primate immune adherence receptors. Immunol Rev 2001; 180:100-11.
6. Paccaud JP, Steiger G, Sjoholm AG, Spaeth PJ, Schifferli JA. Tetanus toxoid-anti-tetanus toxoid complexes: a potential model to study the complement transport system for immune complex in humans. Clin Exp Immunol 1987; 69:468-76.
7. Cockburn IA, Mackinnon MJ, O'Donnell A, et al. Ahuman complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria. Proc Natl Acad Sci USA 2004; 101:272-7.
8. Wong WW, Kennedy CA, Bonaccio ET, et al. Analysis of multiple restriction fragment length polymorphisms of the gene for the human complement receptor type I: duplication of genomic sequences occurs in association with a high molecular mass receptor allotype. J Exp Med 1986; 164:1531-46.
9. Wilson JG, Murphy EE, Wong WW, Klickstein LB, Weis JH, Fearon DT. Identification of a restriction fragment length polymorphism by a CR1 cDNA that correlates with the number of CR1 on erythrocytes. J Exp Med 1986; 164:50-9.
10. Cornillet P, Philbert F, Kazatchkine MD, Cohen JH. Genomic determination of the CR1 (CD35) density polymorphism on erythrocytes using polymerase chain reaction amplification and HindIII restriction enzyme digestion. J Immunol Methods 1991; 136:193-7.
11. Nagayasu E, Ito M, Akaki M, et al. CR1 density polymorphism on erythrocytes of falciparum malaria patients in Thailand. Am J Trop Med Hyg 2001; 64:1-5.
12. Herrera AH, Xiang L, Martin SG, Lewis J, Wilson JG. Analysis of complement receptor type 1 (CR1) expression on erythrocytes and of CR1 allelic markers in Caucasian and African American populations. Clin Immunol Immunopathol 1998; 87:176-83.
13. Rowe JA, Raza A, Diallo DA, et al. Erythrocyte CR1 expression level does not correlate with a HindIII restriction fragment length polymorphism in Africans; implications for studies on malaria susceptibility. Genes Immun 2002; 3:497-500.
14. Cockburn IA, Rowe JA. Erythrocyte complement receptor 1 (CR1) expression level is not associated with polymorphisms in the promoter or 3′ untranslated regions of the CR1 gene. Int J Immunogenet 2006; 33:17-20.
15. Rowe JA, Rogerson SJ, Raza A, et al. Mapping of the region of complement receptor (CR) 1 required for Plasmodium falciparum rosetting and demonstration of the importance of CR1 in rosetting in field isolates. J Immunol 2000; 165:6341-6.
16. Rowe JA, Moulds JM, Newbold CI, Miller LH. P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1. Nature 1997; 388:292-5.
17. Stoute JA. Complement-regulatory proteins in severe malaria: too little or too much of a good thing? Trends Parasitol 2005; 21:218-23.
18. Carlson J, Helmby H, Hill AV, Brewster D, Greenwood BM, Wahlgren M. Human cerebral malaria: association with erythrocyte rosetting and lack of anti-rosetting antibodies. Lancet 1990; 336:1457-60.
19. Treutiger CJ, Hedlund I, Helmby H, et al. Rosette formation in Plasmodium falciparum isolates and anti-rosette activity of sera from Gambians with cerebral or uncomplicated malaria. Am J Trop Med Hyg 1992; 46:503-10.
20. Newbold C, Warn P, Black G, et al. Receptor-specific adhesion and clinical disease in Plasmodium falciparum. Am J Trop Med Hyg 1997; 57:389-98.
21. Heddini A, Pettersson F, Kai O, et al. Fresh isolates from children with severe Plasmodium falciparum malaria bind to multiple receptors. Infect Immun 2001; 69:5849-56.
22. Rowe A, Obeiro J, Newbold CI, Marsh K. Plasmodium falciparum rosetting is associated with malaria severity in Kenya. Infect Immun 1995; 63:2323-6.
23. Rowe JA, Shafi J, Kai OK, Marsh K, Raza A. Nonimmune IgM, but not IgG binds to the surface of Plasmodium falciparum-infected erythrocytes and correlates with rosetting and severe malaria. Am J Trop Med Hyg 2002; 66:692-9.
24. Rogerson SJ, Tembenu R, Dobaño C, Plitt S, Taylor TE, Molyneux ME. Cytoadherence characteristics of Plasmodium falciparum-infected erythrocytes from Malawian children with severe and uncomplicated malaria. Am J Trop Med Hyg 1999; 61:467-72.
25. al-Yaman F, Genton B, Mokela D, et al. Human cerebral malaria: lack of significant association between erythrocyte rosetting and disease severity. Trans R Soc Trop Med Hyg 1995; 89:55-8.
26. Rowe JA, Obiero J, Marsh K, Raza A. Short report: positive correlation between rosetting and parasitemia in Plasmodium falciparum clinical isolates. Am J Trop Med Hyg 2002; 66:458-60.
27. Ho M, Davis TM, Silamut K, Bunnag D, White NJ. Rosette formation of Plasmodium falciparum-infected erythrocytes from patients with acute malaria. Infect Immun 1991; 59:2135-9.
28. National Center for Biotechnology Information. Pan troglodytes (chimpanzee) genome view. Available at: http://www.ncbi.nlm.nih.gov/projects/ mapview/map_search.cgi?taxid=9598. Accessed 2 October 2008.
29. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21:263-5.
30. Cockburn IA, Donvito B, Cohen JH, Rowe JA. A simple method for accurate quantification of complement receptor 1 on erythrocytes preserved by fixing or freezing. J Immunol Methods 2002; 271:59-64.
31. Thomas BN, Donvito B, Cockburn I, et al. A complement receptor-1 polymorphism with high frequency in malaria endemic regions of Asia but not Africa. Genes Immun 2005; 6:31-6.
32. Schifferli JA, Ng YC, Paccaud JP, Walport MJ. The role of hypocomplementaemia and low erythrocyte complement receptor type 1 numbers in determining abnormal immune complex clearance in humans. Clin Exp Immunol 1989; 75:329-35.
33. Madi N, Steiger G, Estreicher J, Schifferli JA. Immune adherence and clearance of hepatitis B surface Ag/Ab complexes is abnormal in patients with systemic lupus erythematosus (SLE). Clin Exp Immunol 1991; 85:373-8.
34. Davies KA, Peters AM, Beynon HL, Walport MJ. Immune complex processing in patients with systemic lupus erythematosus: in vivo imaging and clearance studies. J Clin Invest 1992; 90:2075-83.
35. The International HapMap Consortium. The International HapMap Project. Nature 2003; 426:789-96.
36. Andersen B, Rosenfeld MG. POU domain factors in the neuroendocrine system: lessons from developmental biology provide insights into human disease. Endocr Rev 2001; 22:2-35.