Polymorphism in postinsulin receptor signaling pathway is not associated with polycystic ovary syndrome

Fertility and Sterility

Volumn 90, Issue 6, 2008, Pages 2298-2303

  Jones, Michelle R ^a   Wilson, Scott G ^a,b   Mullin, Ben H ^a   Mead, Robert ^c   Dudbridge, Frank ^d   Watts, Gerald F ^a,b   Stuckey, Bronwyn G A ^a,b  

^a SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c MURDOCH UNIVERSITY   (Australia)

^d MRC BIOSTATISTICS UNIT   (United Kingdom)

Author keywords

GLUT4; insulin resistance; insulin signaling; PIK3R1; polycystic ovary syndrome; polymorphism

Indexed keywords

GLUCOSE TRANSPORTER 4; MYOCYTE ENHANCER FACTOR 2; PROTEIN PIK3R1; PROTEIN SLC2A4RG; RECEPTOR PROTEIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA EXTRACTION; DNA POLYMORPHISM; FEMALE; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; OVARY POLYCYSTIC DISEASE; PHENOTYPE; PRIORITY JOURNAL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADULT; CASE-CONTROL STUDIES; DNA-BINDING PROTEINS; FEMALE; GENE FREQUENCY; GLUCOSE TRANSPORTER TYPE 4; HUMANS; INSULIN; INSULIN RESISTANCE; MADS DOMAIN PROTEINS; MIDDLE AGED; MYOGENIC REGULATORY FACTORS; POLYCYSTIC OVARY SYNDROME; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; WESTERN AUSTRALIA; YOUNG ADULT;

EID: 56649118781     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2007.10.079     Document Type: Article

References (29)

1. Goodarzi M., and Azziz R. Diagnosis, epidemiology, and genetics of the polycystic ovary syndrome. Best Prac Res Clin Endocrinol Metab 20 (2006) 196-205
2. Farah-Eways L., Reyna R., Knochenhauer E.S., Batolucci A.A., and Azziz R. Glucose action and adrenocortical biosynthesis in women with polycystic ovary syndrome. Fertil Steril 81 (2004) 120-125
3. Acien P., Quereda F., Matallin P., Villarroya E., Lopez-Fernandez J.A., Acien M., et al. Insulin, androgens, and obesity in women with and without polycystic ovary syndrome: a heterogenous group of disorders. Fertil Steril 72 (1999) 32-40
4. Tsilchorozidou T., Overton C., and Conway G.S. The pathophysiology of polycystic ovary syndrome. Clin Endocrinol 60 (2004) 1-17
5. Qin K., Ehrmann D.A., Cox N., Refetoff S., and Rosenfield R.L. Identification of a functional polymorphism of the human type 5 17β-hydroxysteroid dehydrogenase gene associated with polycystic ovary syndrome. J Clin Endocrinol Metab 91 (2006) 270-276
6. Holte J. Disturbances in insulin secretion and sensitivity in women with polycystic ovary syndrome. Clin Endocrinol Metab 10 (1996) 221-247
7. Nestler J., Jakubowicz D.J., Falcon de Vargas A., Brik C., Quintero N., and Medina F. Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositoglycan mediators as the signal transduction system. J Clin Endocrinol Metab 83 (1998) 2001-2005
8. Hansen T., Andersen C.B., Echwald S.M., Urhammer S.A., Calusen J.O., Vestergaard H., et al. Identification of a common amino acid polymorphism in the p85α regulatory subunit of phoshphatidylinositol 3-kinase: effects on glucose disappearance constant, glucose effectiveness, and the insulin sensitivity. Diabetes 46 (1997) 494-501
9. Seraphim P., Nunes M.T., and Machado U.F. GLUT4 protein expression in obese and lean 12-month-old rats: insights from different types of data analysis. Br J Med Biol Res 34 (2001) 1353-1362
10. Miura S., Tsunoda N., Ikeda S., Kai Y., Ono M., Maruyama K., et al. Regulatory sequence elements of mouse GLUT4 gene expression in adipose tissues. Biochem Biophys Res Comm 312 (2003) 277-284
11. Knight J.B., Eyster C.A., Griesel B.A., and Olson A.L. Regulation of the human GLUT4 gene promoter: Interaction between a transcriptional activator and myocyte enhancement factor 2A. PNAS 100 (2003) 14725-14730
12. Diamanti-Kandarakis E., and Papavassiliou A.G. Molecular Mechanisms of insulin resistance in polycystic ovary syndrome. Trends Mol Med 12 (2006) 324-332
13. Antonetti D., Algenstaedt P., and Kahn C.R. Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain. Mol Cell Biol 16 (1996) 2195-2203
14. Buse J., Yasuda K., and Lay T.P. Human GLUT4 muscle-fat glucose transporter gene:characterization and genetic variation. Diabetes 41 (1992) 1436-1445
15. Zawadski J., Dunaif A., Givens J.R., Haseltine F.P., and Merriam G.R. Diagnostic criteria for polycystic ovary syndrome: towards a rational approach (1992), Blackwell Scientific, Boston
16. Jones M., Italiano L., Wilson S.G., Mullin B.H., Mead R., Dudbridge F., Watts G.F., and Stuckey B.G.A. Polymorphism in HSD17B6 is associated with key features of PCOS. Fertil Steril 86 (2006) 1438-1446
17. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genetic Epidemiol 25 (2003) 115-121
18. Carter K., McCaskie P.A., and Palmer L.J. JLIN: a java based linkage disequilibrium plotter. BMC Bioinformatics 9 (2006) 60
19. Carmina E., and Lobo R.A. Use of fasting blood to assess the prevalence of insulin resistance in women with polycystic ovary syndrome. Fertil Steril 82 (2004) 661-665
20. Goodarzi M.O., Shah N.A., Antoine H.J., Pall M., Guo X., and Azziz R. Variants in the 5alpha-reductase type 1 and type 2 genes are associated with polycystic ovary syndrome and the severity of hirsutism in affected women. J Clin Endocrinol Metab 91 (2006) 4085-4091
21. Diamanti-Kandarakis E., and Papavassiliou A.G. Molecular mechanisms of insulin resistance in polycystic ovary syndrome. Trends Mol Med 12 (2006) 324-332
22. Ehrmann D., Sturis J., Byrne M., Karrison T., Rosenfield R., and Polonsky K. Insulin secretory defects in polycystic ovary syndrome: relationship to insulin sensitivity and family history of non-insulin dependent-diabetes-mellitus. J Clin Invest 96 (1995) 520-527
23. Moran C., Huerta R., Conway-Myers B.-A., Hines G.A., and Azziz R. Altered autophosphorylation of the insulin receptor in the ovary of a woman with polycystic ovary syndrome. Fertil Steril 75 (2001) 625-628
24. Ciaraldi T., El-Roeiy A., Madar Z., Reichart D., Olefsky J.M., and Yen S. Cellular mechanisms of insulin resistance in polycystic ovary syndrome. J Clin Endocrinol Metab 75 (1992) 577-583
25. Dunaif A., Xia J., Book C.-B., Schnecker E., and Tang Z. Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. J Clin Invest 96 (1995) 801-810
26. Salehi M., Bravo-Vera R., Skeikh A., Gouller A., and Poretsky L. Pathogenesis of polycystic ovary syndrome: what is the role of obesity?. Metabolism 53 (2004) 358-376
27. Corbould A., Kim Y.-B., Youngren J.F., Pender C., Kahn B.B., Lee A., et al. Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling. Am J Physiol Endocrinol Metab 288 (2005) E1047-E1054
28. Fulghesu A., Cucinelli F., Pavone V., Murgia F., Guido M., Caruso A., et al. Changes in luteinizing hormone and insulin secretion on polycystic ovarian syndrome. Hum Reprod 14 (1999) 611-617
29. Moran C., Garcia-Hernandez E., Barahona E., Gonzalez S., and Bermudez J.A. Relationship between insulin resistance and gonadotropin dissociation in obese and nonobese women with polycystic ovary syndrome. Fertil Steril 80 (2003) 1466-1472