Oestrogen receptor expression and neuronal nitric oxide synthase in the clitoris and preputial gland structures of mice

BJU International

Volumn 102, Issue 11, 2008, Pages 1719-1723

  Martin Alguacil, Nieves ^b,c   Schober, Justine ^a,d   Kow, Lee Ming ^b   Pfaff, Donald ^b  

^a Rockefeller University ^*  (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d HAMOT MEDICAL CENTER   (United States)

Author keywords

; Clitoris; Mice; Neuronal nitric oxide synthase; Oestrogen receptor

Indexed keywords

ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE;

ANIMAL TISSUE; APOCRINE GLAND; ARTICLE; CLITORIS; CYTOPLASM; FEMALE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PREPUTIAL GLAND; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR DENSITY; VAGINA;

ANIMALS; CLITORIS; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; MICE; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE TYPE I;

EID: 56649116183     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2008.07989.x     Document Type: Article

References (36)

1. Clark JH, Hardin JW, McCormack SA. Estrogen receptor binding and growth of the reproductive tract. Pediatrics 1978 62 : 1121 7
2. Kow LM, Pfaff DW. Effects of estrogen treatment on the size of receptive field and response threshold of pudendal nerve in the female rat. Neuroendocrinology 1973-74 13 : 299 313
3. Burnett AL, Tillman SL, Chang TS et al. Immunohistochemical localization of nitric oxide synthase in the autonomic innervation of the human penis. J Urol 1993 150 : 73 6
4. Rajfer J, Aronson WJ, Bush PA, Dorey FJ, Ignarro LJ. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl J Med 1992 326 : 90 4
5. Mowa CN, Iwanaga T. Differential distribution of oestrogen receptor-alpha and - beta mRNAs in the female reproductive organ of rats as revealed by in situ hybridization. J Endocrinol 2000 165 : 59 66
6. Pelletier G, El-Alfy M. Immunocytochemical localization of estrogen receptors alpha and beta in the human reproductive organs. J Clin Endocrinol Metab 2000 85 : 4835 40
7. Couse JF, Korach KS. Estrogen receptor-alpha mediates the detrimental effects of neonatal diethylstilbestrol (DES) exposure in the murine reproductive tract. Toxicology 2004 205 : 55 63
8. Hodgins MB, Spike RC, Mackie RM, MacLean AB. An immunohistochemical study of androgen, oestrogen and progesterone receptors in the vulva and vagina. Br J Obstet Gynaecol 1998 105 : 216 22
9. Vermeirsch H, Van den Broeck W, Simoens P. Immunolocalization of sex steroid hormone receptors in canine vaginal and vulvar tissue and their relation to sex steroid hormone concentrations. Reprod Fertil Dev 2002 14 : 251 8
10. Hess RA, Gist DH, Bunick D et al. Estrogen receptor (alpha and beta) expression in the excurrent ducts of the adult male rat reproductive tract. J Androl 1997 18 : 602 11
11. Mowa CN, Iwanaga T. Expression of estrogen receptor-alpha and - beta mRNAs in the male reproductive system of the rat as revealed by in situ hybridization. J Mol Endocrinol 2001 26 : 165 74
12. Nie R, Zhou Q, Jassim E, Saunders PT, Hess RA. Differential expression of estrogen receptors alpha and beta in the reproductive tracts of adult male dogs and cats. Biol Reprod 2002 66 : 1161 8
13. Dietrich W, Haitel A, Huber JC, Reiter WJ. Expression of estrogen receptors in human corpus cavernosum and male urethra. J Histochem Cytochem 2004 52 : 355 60
14. Crescioli C, Maggi M, Vannelli GB et al. Expression of functional estrogen receptors in human fetal male external genitalia. J Clin Endocrinol Metab 2003 88 : 1815 24
15. Berman JR, McCarthy MM, Kyprianou N. Effect of estrogen withdrawal on nitric oxide synthase expression and apoptosis in the rat vagina. Urology 1998 51 : 650 6
16. Park K, Ahn K, Lee S, Ryu S, Park Y, Azadzoi KM. Decreased circulating levels of estrogen alter vaginal and clitoral blood flow and structure in the rabbit. Int J Impot Res 2001 13 : 116 24
17. Laan E, van Lunsen RH. Hormones and sexuality in postmenopausal women: a psychophysiological study. J Psychosom Obstet Gynaecol 1997 18 : 126 33
18. Moncada S, Rees DD, Schulz R, Palmer RM. Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo. Proc Natl Acad Sci USA 1991 88 : 2166 70
19. Hoyle CH, Stones RW, Robson T, Whitley K, Burnstock G. Innervation of vasculature and microvasculature of the human vagina by NOS and neuropeptide-containing nerves. J Anat 1996 188 : 633 44
20. Burnett AL, Lowenstein CJ, Bredt DS, Chang TS, Snyder SH. Nitric oxide: a physiologic mediator of penile erection. Science 1992 257 : 401 3
21. Yucel S, De Souza A Baskin LS. Neuroanatomy of the human female lower urogenital tract. J Urol 2004 172 : 191 5
22. Al-Hijji J, Larsson B, Batra S. Nitric oxide synthase in the rabbit uterus and vagina: hormonal regulation and functional significance. Biol Reprod 2000 62 : 1387 92
23. Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA. Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 1996 93 : 5925 30
24. Pelletier G, Labrie C, Labrie F. Localization of oestrogen receptor alpha, oestrogen receptor beta and androgen receptors in the rat reproductive organs. J Endocrinol 2000 165 : 359 70
25. Lubahn DB, Moyer JS, Golding TS, Couse JF, Korach KS, Smithies O. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc Natl Acad Sci USA 1993 90 : 11162 6
26. Wang H, Eriksson H, Sahlin L. Estrogen receptors alpha and beta in the female reproductive tract of the rat during the estrous cycle. Biol Reprod 2000 63 : 1331 40
27. Chen Z, Yuhanna IS, Galcheva-Gargova Z, Karas RH, Mendelsohn ME, Shaul PW. Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen. J Clin Invest 1999 103 : 401 6
28. Wyckoff MH, Chambliss KL, Mineo C et al. Plasma membrane estrogen receptors are coupled to endothelial nitric-oxide synthase through Galpha (i). J Biol Chem 2001 276 : 27071 6
29. Munarriz R, Kim SW, Kim NN, Traish A, Goldstein I. A review of the physiology and pharmacology of peripheral (vaginal and clitoral) female genital arousal in the animal model. J Urol 2003 170 : S40 5
30. Uckert S, Ehlers V, Nuser V et al. In vitro functional responses of isolated human vaginal tissue to selective phosphodiesterase inhibitors. World J Urol 2005 23 : 398 404
31. Ceccatelli S, Grandison L, Scott RE, Pfaff DW, Kow LM. Estradiol regulation of nitric oxide synthase mRNAs in rat hypothalamus. Neuroendocrinology 1996 64 : 357 63
32. Mendelsohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system. N Engl J Med 1999 340 : 1801 11
33. Chambliss KL, Shaul PW. Estrogen modulation of endothelial nitric oxide synthase. Endocr Rev 2002 23 : 665 86
34. Chambliss KL, Yuhanna IS, Anderson RG, Mendelsohn ME, Shaul PW. ERbeta has nongenomic action in caveolae. Mol Endocrinol 2002 16 : 938 46
35. Kelly MJ, Levin ER. Rapid actions of plasma membrane estrogen receptors. Trends Endocrinol Metab 2001 12 : 152 6
36. Chambliss KL, Simon L, Yuhanna IS, Mineo C, Shaul PW. Dissecting the basis of nongenomic activation of endothelial nitric oxide synthase by estradiol: role of ERalpha domains with known nuclear functions. Mol Endocrinol 2005 19 : 277 89