Cofilin phosphorylation mediates proliferation in response to platelet-derived growth factor-BB in rat aortic smooth muscle cells

Journal of Pharmacological Sciences

Volumn 108, Issue 3, 2008, Pages 372-379

  Won, Kyung Jong ^a   Seung, Hwa Park ^a   Park, Taekyu ^b   Lee, Chang Kwon ^a   Hwan, Myung Lee ^a   Wahn, Soo Choi ^a   Kim, Sun Jong ^a   Park, Pyo Jam ^b   Jang, Hyung Kwan ^c   Soon, Heum Kim ^a   Kim, Bokyung ^a  

^a Konkuk University School of Medicine   (South Korea)

^b Konkuk University   (South Korea)

^c Chonbuk National University   (South Korea)

Author keywords

c Jun N terminal kinase (JNK); Cofilin; Platelet derived growth factor BB (PDGF BB); Proliferation; Rat aortic smooth muscle cell (RASMC)

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BROXURIDINE; MITOGEN ACTIVATED PROTEIN KINASE; PICEATANNOL; PLATELET DERIVED GROWTH FACTOR BB; PROTEIN KINASE SYK; PROTEIN TYROSINE KINASE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; AORTA MEDIA; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME ACTIVATION; MALE; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA; CELL PROLIFERATION; CELLS, CULTURED; COFILIN 2; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; RNA INTERFERENCE; RNA, SMALL INTERFERING; SRC-FAMILY KINASES; TIME FACTORS;

EID: 56649116083     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.FP0072354     Document Type: Article

References (37)

1. Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med. 1999;340:115-126.
2. Ioroi T, Yamamori M, Yagi K, Hirai M, Zhan Y, Kim S, et al. Dominant negative c-Jun inhibits platelet-derived growth factor-directed migration by vascular smooth muscle cells. J Pharmacol Sci. 2003;91:145-148.
3. Raines EW. PDGF-BB and cardiovascular disease. Cytokine Growth Factor Rev. 2004;15:237-254.
4. Millette E, Rauch BH, Kenargy RD, Daum G, Clowes AW. Platelet-derived growth factor-BB transactivates the fibroblast growth factor receptor to induce proliferation in human smooth muscle cells. Trends Cardiovasc Med. 2006;16:25-28.
5. Perona R. Cell signalling: growth factors and tyrosine kinase receptors. Clin Transl Oncol. 2006;8:77-82.
6. Pearson R, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K, et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev. 2001;22:153-183.
7. Turner CE. Paxillin and focal adhesion signaling. Nat Cell Biol. 2000;2:E231-E236.
8. Newby AC. Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates. Cardiovasc Res. 2006;69:614-624.
9. Zhan Y, Kim S, Izumi Y, Izumiya Y, Nakao T, Miyazaki H, et al. Role of JNK, p38, and ERK in platelet-derived growth factor-induced vascular proliferation, migration, and gene expression. Arterioscler Thromb Vasc Biol. 2003;23:795-801.
10. Kurosaki T. Functional dissection of BCR signaling pathways. Curr Opin Immunol. 2000;12:276-281.
11. Inatome R, Yanagi S, Takano T, Yamamura H. A critical role for Syk in endothelial cell proliferation and migration. Biochem Biophys Res Commun. 2001;286:195-199.
12. Lee CK, Lee HM, Kim HJ, Park HJ, Won KJ, Roh HY, et al. Syk contributes to PDGF-BB-mediated migration of rat aortic smooth muscle cells via MAPK pathways. Cardiovas Res. 2007;74:159-168.
13. Lee HM, Kim HJ, Park HJ, Won KJ, Kim J, Shin HS, et al. Spleen tyrosine kinase participates in Src-mediated migration and proliferation by PDGF-BB in rat aortic smooth muscle cells. Arch Pharm Res. 2007;30:761-769.
14. Lee HM, Won KJ, Kim J, Park HJ, Kim HJ, Roh HY, et al. Endothelin-1 induces contraction via a Syk-mediated p38 mitogen-activated protein kinase pathway in rat aortic smooth muscle. J Pharmacol Sci. 2007;103:427-433.
15. Takada Y, Aggarwal BB. TNF activates Syk protein tyrosine kinase leading to TNF-induced MAPK activation, NF-κB activation, and apoptosis. J Immunol. 2004;173:1066-1077.
16. Thomas SM, Brugge JS. Cellular functions regulated by Src family kinase. Annu Rev Cell Dev Biol. 1997;13:513-609.
17. Brown MT, Cooper JA. Regulation, substrates and functions of Src. Biochim Biophys Acta. 1996;1287:121-149.
18. Sayeski PP, Ali MS. The critical role of c-Src and the Shc/Grb2/ERK2 signaling pathway in angiotensin II-dependent VSMC proliferation. Exp Cell Res. 2003;287:339-349.
19. Barone MV, Courtneidge SA. Myc but not Fos rescue of PDGF-BB signalling block caused by kinase-inactive Src. Nature. 1995;378:509-512.
20. Zhan Y, Kim S, Yasumoto H, Namba M, Miyazaki H, Iwao H. Effects of dominant-negative c-Jun on platelet-derived growth factor-induced vascular smooth muscle cell proliferation. Arterioscler Thromb Vasc Biol. 2002;22:82-88.
21. dos Remedios CG, Chhabra D, Kekic M, Dedova IV, Tsubakihara M, Berry DA, et al. Actin binding proteins: regulation of cytoskeletal microfilaments. Physiol Rev. 2003;83:433-473.
22. Sotiropoulos A, Gineitis D, Copeland J, Treisman R. Signal-regulated activation of serum response factor is mediated by changes in actin dynamics. Cell. 1999;98:159-169.
23. Bamburg JR. Proteins of the ADF/cofilin family: essential regulators of actin dynamics. Annu Rev Cell Dev Biol. 1999;15:185-230.
24. Rosenblatt J, Mitchison TJ. Actin, cofilin and cognition. Nature. 1998;393:739-740.
25. Wang Y, Shibasaki F, Mizuno K. Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. J Biol Chem. 2005;280:12683-12689.
26. Huang TY, DerMardirossian C, Bokoch GM. Cofilin phosphatases and regulation of actin dynamics. Curr Opin Cell Biol. 2006;18:26-31.
27. Gohla A, Birkenfeld J, Bokoch GM. Chronophin, a novel HADtype serine protein phosphatase, regulates cofilin-dependent actin dynamics. Nat Cell Biol. 2005;7:21-29.
28. Nebl G, Fischer S, Penzel R, Samstag Y. Dephosphorylation of cofilin is regulated through Ras and requires the combined activities of the Ras-effectors MEK and PI3K. Cell Signal. 2004;16:235-243.
29. Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, et al. Cofilin phosphorylation by LIM kinase 1 and its role in Rac-mediated actin reorganization. Nature. 1998;393:809-812.
30. Lee CK, Park HJ, So HH, Kim HJ, Lee KS, Choi WS, et al. Proteomic profiling and identification of cofilin responding to oxidative stress in vascular smooth muscle. Proteomics. 2006;6:6455-6475.
31. Subramaniam V, Vincent IR, Jothy S. Upregulation and dephosphorylation of cofilin: modulation by CD44 variant isoform in human colon cancer cells. Exp Mol Pathol. 2005;79:187-193.
32. Bagheri-Yarmand R, Mazumdar A, Sahin AA, Kumar R. LIM kinase 1 increases tumor metastasis of human breast cancer cells via regulation of the urokinase-type plasminogen activator system. Int J Cancer. 2006;118:2703-2710.
33. Bongalon S, Dai YP, Singer CA, Yamboliev IA. PDGF-BB and IL-1 upregulate cofilin and LIMK2 in canine cultured pulmonary artery smooth muscle cells. J Vasc Res. 2004;41:412-421.
34. Zhan Q, Bamburg JR, Badwey JA. Products of phosphoinositide specific phospholipase C can trigger dephosphorylation of cofilin in chemoattractant stimulated neutrophils. Cell Motil Cytoskeleton. 2003;54:1-15.
35. Choi DY, Toledo-Aral JJ, Segal R, Halegoua S. Sustained signaling by phospholipase C mediates nerve growth factor-triggered gene expression. Mol Cell Biol. 2001;21:2695-2705.
36. 2+ stores in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 1995;15:44-51.
37. Kyaw M, Yoshizumi M, Tsuchiya K, Kagami S, Izawa Y, Fujita Y, et al. Src and Cas are essentially but differentially involved in angiotensin II-stimulated migration of vascular smooth muscle cells via extracellular signal-regulated kinase 1 /2 and c-Jun NH2-terminal kinase activation. Mol Pharmacol. 2004;65:832-841.