Differential-reinforcement-of-low-rate-schedule performance and nicotine administration: A systematic investigation of dose, dose-regimen, and schedule requirement

Behavioural Pharmacology

Volumn 19, Issue 7, 2008, Pages 683-697

  Kirshenbaum, Ari P ^a   Brown, Seth J ^a   Hughes, David M ^a   Doughty, Adam H ^b  

^a SAINT MICHAEL'S COLLEGE   (United States)

^b School of Business   (United States)

Author keywords

Chronic administration; Differential reinforcement of low rate schedule; Interresponse time greater than X schedule; Nicotine; Rat; Reinforcer magnitude; Sensitization

Indexed keywords

NICOTINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; MALE; NONHUMAN; RAT; REINFORCEMENT; SENSITIZATION; SUBSTANCE ABUSE;

ANIMALS; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INHIBITION (PSYCHOLOGY); INJECTIONS, SUBCUTANEOUS; MALE; MOTIVATION; NICOTINE; RATS; RATS, SPRAGUE-DAWLEY; REINFORCEMENT SCHEDULE; TIME PERCEPTION; TOBACCO USE DISORDER;

EID: 56649115983     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/FBP.0b013e328315ecbb     Document Type: Article

References (36)

1. Amsel A, Surridge CT (1964). The influence of magnitude of reward on the aversive properties of anticipatory frustration. Can J Psychol 18:321-327.
2. Balcells-Olivero M, Richards JB, Seiden LS (1997). Sensitization to amphetamine on the differential-reinforcement-of-low-rate 72-s schedule. Psychopharmacology 133: 207-213.
3. Bechara A, Damasio H (2002). Decision-making and addiction (part I): impaired activation of somatic states in substance dependent individuals when pondering decisions with negative future consequences. Neuropsychology 40:1675-1689.
4. Bickel WK, Marsh LA (2001). Toward a behavioral economic understanding of drug dependence: delay discounting processes. Addiction 96:73-86.
5. Bizot JC (1997). Effects of psychoactive drugs on temporal discrimination in rats. Behav Pharmacol 8:293.
6. Caggiula AR, Donny EC, White AR, Chaudhri N, Booth S, Gharib MA, et al. (2002). Environmental stimuli promote the acquisition of nicotine self-administration in rats. Psychopharmacology 163:230-237.
7. Chaudri N, Caggiula AR, Donny EC, Booth S, Gharib M, Craven L, et al. (2006). Operant responding for conditioned and unconditioned reinforcers in rats is differentially enhanced by the primary reinforcing and reinforcement-enhancing effects of nicotine. Psychopharmacology 189:27-36.
8. Dallery J, Locey ML (2005). Effects of acute and chronic nicotine on impulsive choice in rats. Behav Pharmacol 16:15-23.
9. Di Chiara G (2002). Nucleus accumbens shell and core dopamine: differential role in behavior and addiction. Behav Brain Res 137:75.
10. Di Chiara G, Bassareo V (2007). Reward system and addiction: what dopamine does and doesn't do. Curr Opin Pharmacol 7:69-76.
11. Donny EC, Chaudhri N, Caggiula AR, Evans-Martin FF, Booth S, Gharib MA, et al. (2003). Operant responding for a visual reinforcer in rats is enhanced by noncontingent nicotine: implications for nicotine self-administration and reinforcement Psychopharmacology 169:68-76.
12. Doughty AH, Richards JB (2002). Effects of reinforcer magnitude on responding under differential-reinforcement-of-low-rate schedules of rats and pigeons. J Exp Anal Behav 78:17-30.
13. Evenden JL (1999). Varieties of impulsivity. Psychopharmacology 146:348-361.
14. Gallistel CR, King A, McDonald R (2004). Sources of Variability and Systematic Error in Mouse Timing Behavior. J Exp Psychol Anim Behav Proc 30:3-16.
15. Grace RC, Nevin JA (2000). Response strength and temporal control in fixed-interval schedules. Anim Learn Behav 28:313.
16. Jentsch JD, Taylor JR (1999). Impulsivity resulting from frontosotnatal dysfunction in drug abuse: implications for the control of behavior by reward related stimuli. Psychopharmacology 146:373-390.
17. Killeen PR (1985). Incentive theory: IV. Magitude of reward. J Exp Anal Behav 43:407-417.
18. Koob GF (1997). Opponent process model and psychostimulant addiction. Pharmacol Biochem Behav 57:513.
19. Ludvig EA, Conover K, Shizgal P (2007). The effects of reinforcer magnitude on timing in rats. J Exp Anal Behav 87:201.
20. MacEwen D, Killeen PR (1991). The effects of rate and amount of reinforcement on the speed of the pacemaker in pigeons' timing behavior. Anim Learn Behav 19:164.
21. McClure GYH, McMillan DE (1997). Effects of drugs on response duration differentiation. VI: differential effects under differential reinforcement of low rates of responding schedules. J Pharmacol Exp Ther 281:1368-1380.
22. MED Associates Inc., Tatham TA (1991). MED-PC Medstate notation. East Fairfield, NH: MED Associates Inc.
23. Morrison CF (1968). A comparison of the effects of nicotine and amphetamine on DRL performance in the rat. Psychopharmacologia 12:176-180.
24. Olausson P, Jentsch JD, Taylor JR (2004a). Nicotine enhances responding with conditioned reinforcement. Psychopharamcology 171:173-178.
25. Olausson P, Jentsch JD, Taylor JR (2004b). Repeated nicotine exposure enhances responding with conditioned reinforcement. Psychopharmacology 173:98-104.
26. Olmstead MC (2006). Animal models of drug addiction: where do we go from here? Q J Exp Psychol 59:625-653.
27. Popke EJ, Mayorga AJ, Fogle CM, Paule MG (2000). Effects of acute nicotine on several operant behaviors in rats. Pharmacol Biochem Behav 65:247-254.
28. Pothuizen HH, Jongen-Relo AL, Feldon J, Yee BK (2005). Double dissociation of the effects of selective accumbens core and shell lesions on impulsive-choice behavior and salience learning in rats. Eur J Neurosci 22:2605-2616.
29. Pradhan SN, Dutta SN (1970). Comparative effects of nicotine and amphetamine on timing behavior in rats. Neuropharmacology 9:9.
30. Richards JB, Sabol KE, Seiden LS (1993). DRL interresponse-time distributions: quantification by peak deviation analysis. J Exp Anal Behav 60:361.
31. Robinson TE, Berridge KC (2001). Incentive-sensitization and addiction. Addiction 96:103-114.
32. Schuster CR, Zimmerman J (1961). Timing behavior during prolonged treatment with DL-amphetamine. J Exp Anal Behav 4:327-330.
33. Shim I, Javiad JI, Wirtshafter D, Jang S, Shin K, Lee H, et al. (2001). Nicotine-induced behavioral sensitization is associated with extracellular dopamine release and expression of c-Fos in the striatum and nucleus accumbens of the rat. Behav Brain Res 121:137-147.
34. Schoffelmeer ANM, De Vries TJ, Wardeh G, van de Ven HWM, Vanderschuren LJMJ (2002). Psychostimulant-induced behavioral sensitization depends on nicotinic receptor activation. J Neurosci 22:3268-3276.
35. Staddon JER (1965). Some properties of spaced responding in pigeons. J Exp Anal Behav 8:19.
36. Van Den Broek MD, Bradshaw CM, Szabadi E (1987). Behaviour of impulsive and non-impulsive humans in a temporal differentiation schedule of reinforcement. Personality Individual Differences 8:233-239.