Mn2+ regulates myeloma cell adhesion differently than the proadhesive cytokines HGF, IGF-1, and SDF-1α

European Journal of Haematology

Volumn 81, Issue 6, 2008, Pages 437-447

  Slørdahl, Tobias S ^a,b   Hov, Håkon ^a   Holt, Randi U ^a,b   Baykov, Vadim ^a,c   Syversen, Tore ^a   Sundan, Anders ^a   Waage, Anders ^a,d   Børset, Magne ^a,d  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c PAVLOV FIRST SAINT PETERSBURG STATE MEDICAL UNIVERSITY   (Russian Federation)

^d TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

Author keywords

Adhesion; Divalent cations; Hepatocyte growth factor; Insuline like growth factor 1; Integrins; Mn2+; Multiple myeloma; Stromal cell derived factor 1 ; Very late antigen 4

Indexed keywords

CYTOKINE; DIVALENT CATION; FIBRONECTIN; MANGANESE; MITOGEN ACTIVATED PROTEIN KINASE; SCATTER FACTOR; SOMATOMEDIN C; STROMAL CELL DERIVED FACTOR 1ALPHA; VERY LATE ACTIVATION ANTIGEN 4; CXCL12 PROTEIN, HUMAN; HGF PROTEIN, HUMAN; STROMAL CELL DERIVED FACTOR 1; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BONE MARROW; CELL ADHESION; CELL HOMING; CELL INTERACTION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOLOGY; HUMAN; HUMAN CELL; IN VIVO STUDY; MULTIPLE MYELOMA; MYELOMA CELL; PRIORITY JOURNAL; BIOSYNTHESIS; CELL SURVIVAL; DRUG EFFECT; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

BONE MARROW; CATIONS, DIVALENT; CELL ADHESION; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHEMOKINE CXCL12; FIBRONECTINS; HEPATOCYTE GROWTH FACTOR; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTEGRIN ALPHA4BETA1; MANGANESE; MAP KINASE SIGNALING SYSTEM; MULTIPLE MYELOMA; NEOPLASM PROTEINS;

EID: 56649114128     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2008.01148.x     Document Type: Article

References (43)

1. Dalton WS. The tumor microenvironment: focus on myeloma. Cancer Treat Rev 2003 29 (Suppl. 1 11 9.
2. Mitsiades CS, Mitsiades N, Munshi NC, Anderson KC. Focus on multiple myeloma. Cancer Cell 2004 6 : 439 44.
3. van de Donk NW, Lokhorst HM, Bloem AC. Growth factors and antiapoptotic signaling pathways in multiple myeloma. Leukemia 2005 19 : 2177 85.
4. Humphries MJ. Integrin structure. Biochem Soc Trans 2000 28 : 311 39.
5. Giancotti FG, Ruoslahti E. Integrin signaling. Science 1999 285 : 1028 32.
6. Elices MJ, Osborn L, Takada Y, Crouse C, Luhowskyj S, Hemler ME, Lobb RR. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 1990 60 : 577 84.
7. Lokhorst HM, Lamme T, de SM, Klein S, de Weger RA, van OR, Bloem AC. Primary tumor cells of myeloma patients induce interleukin-6 secretion in long-term bone marrow cultures. Blood 1994 84 : 2269 77.
8. Uchiyama H, Barut BA, Mohrbacher AF, Chauhan D, Anderson KC. Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion. Blood 1993 82 : 3712 20.
9. Sanz-Rodriguez F, Ruiz-Velasco N, Pascual-Salcedo D, Teixido J. Characterization of VLA-4-dependent myeloma cell adhesion to fibronectin and VCAM-1. Br J Haematol 1999 107 : 825 34.
10. Leitinger B, McDowall A, Stanley P, Hogg N. The regulation of integrin function by Ca(2+). Biochim Biophys Acta 2000 1498 : 91 8.
11. Masumoto A, Hemler ME. Multiple activation states of VLA-4. Mechanistic differences between adhesion to CS1/fibronectin and to vascular cell adhesion molecule-1. J Biol Chem 1993 268 : 228 34.
12. Dransfield I, Cabanas C, Craig A, Hogg N. Divalent cation regulation of the function of the leukocyte integrin LFA-1. J Cell Biol 1992 116 : 219 26.
13. Smith JW, Piotrowicz RS, Mathis D. A mechanism for divalent cation regulation of beta 3-integrins. J Biol Chem 1994 269 : 960 7.
14. Egger LA, Cao J, McCallum C, et al. A small molecule alpha4beta1/ alpha4beta7 antagonist differentiates between the low-affinity states of alpha4beta1 and alpha4beta7: characterization of divalent cation dependence. J Pharmacol Exp Ther 2003 306 : 903 13.
15. Hynes RO. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 1992 69 : 11 25.
16. Sanz-Rodriguez F, Hidalgo A, Teixido J. Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1. Blood 2001 97 : 346 51.
17. Tai YT, Podar K, Catley L, et al. Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3′-kinase/AKT signaling. Cancer Res 2003 63 : 5850 8.
18. Tajima H, Matsumoto K, Nakamura T. Regulation of cell growth and motility by hepatocyte growth factor and receptor expression in various cell species. Exp Cell Res 1992 202 : 423 31.
19. Borset M, Hjorth-Hansen H, Seidel C, Sundan A, Waage A. Hepatocyte growth factor and its receptor c-met in multiple myeloma. Blood 1996 88 : 3998 4004.
20. Borset M, Lien E, Espevik T, Helseth E, Waage A, Sundan A. Concomitant expression of hepatocyte growth factor/scatter factor and the receptor c-MET in human myeloma cell lines. J Biol Chem 1996 271 : 24655 61.
21. Holt RU, Baykov V, Ro TB, Brabrand S, Waage A, Sundan A, Borset M. Human myeloma cells adhere to fibronectin in response to hepatocyte growth factor. Haematologica 2005 90 : 479 88.
22. Hov H, Holt RU, Ro TB, Fagerli UM, Hjorth-Hansen H, Baykov V, Christensen JG, Waage A, Sundan A, Borset M. A selective c-met inhibitor blocks an autocrine hepatocyte growth factor growth loop in ANBL-6 cells and prevents migration and adhesion of myeloma cells. Clin Cancer Res 2004 10 : 6686 94.
23. Standal T, Borset M, Lenhoff S, Wisloff F, Stordal B, Sundan A, Waage A, Seidel C. Serum insulinlike growth factor is not elevated in patients with multiple myeloma but is still a prognostic factor. Blood 2002 100 : 3925 9.
24. Borset M, Waage A, Brekke OL, Helseth E. TNF and IL-6 are potent growth factors for OH-2, a novel human myeloma cell line. Eur J Haematol 1994 53 : 31 7.
25. Hjertner O, Hjorth-Hansen H, Borset M, Seidel C, Waage A, Sundan A. Bone morphogenetic protein-4 inhibits proliferation and induces apoptosis of multiple myeloma cells. Blood 2001 97 : 516 22.
26. Borset M, Hjertner O, Yaccoby S, Epstein J, Sanderson RD. Syndecan-1 is targeted to the uropods of polarized myeloma cells where it promotes adhesion and sequesters heparin-binding proteins. Blood 2000 96 : 2528 36.
27. Arroyo AG, Garcia-Pardo A, Sanchez-Madrid F. A high affinity conformational state on VLA integrin heterodimers induced by an anti-beta 1 chain monoclonal antibody. J Biol Chem 1993 268 : 9863 8.
28. Faull RJ, Kovach NL, Harlan JM, Ginsberg MH. Affinity modulation of integrin alpha 5 beta 1: regulation of the functional response by soluble fibronectin. J Cell Biol 1993 121 : 155 62.
29. Frelinger AL III., Du XP, Plow EF, Ginsberg MH. Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function. J Biol Chem 1991 266 : 17106 11.
30. Garcia-Gila M, Cabanas C, Garcia-Pardo A. Analysis of the activation state of alpha4beta1 integrin in human B cell lines derived from myeloma, leukemia or lymphoma. FEBS Lett 1997 418 : 337 40.
31. Luque A, Gomez M, Puzon W, Takada Y, Sanchez-Madrid F, Cabanas C. Activated conformations of very late activation integrins detected by a group of antibodies (HUTS) specific for a novel regulatory region (355-425) of the common beta 1 chain. J Biol Chem 1996 271 : 11067 75.
32. Thamilselvan V, Fomby M, Walsh M, Basson MD. Divalent cations modulate human colon cancer cell adhesion. J Surg Res 2003 110 : 255 65.
33. Van der Voort van Z, Conway WC, Thamilselvan V, Polin L, Basson MD. Divalent cations influence colon cancer cell adhesion in a murine transplantable tumor model. Am J Surg 2005 190 : 701 7.
34. Grzesiak JJ, Pierschbacher MD. Shifts in the concentrations of magnesium and calcium in early porcine and rat wound fluids activate the cell migratory response. J Clin Invest 1995 95 : 227 33.
35. Sigurdson SL, Lwebuga-Mukasa JS. Divalent cation-dependent regulation of rat alveolar epithelial cell adhesion and spreading. Exp Cell Res 1994 213 : 71 9.
36. Lorentz A, Schuppan D, Gebert A, Manns MP, Bischoff SC. Regulatory effects of stem cell factor and interleukin-4 on adhesion of human mast cells to extracellular matrix proteins. Blood 2002 99 : 966 72.
37. Platanias LC. Map kinase signaling pathways and hematologic malignancies. Blood 2003 101 : 4667 79.
38. Luque R, Garcia-Trujillo JA, Camara C, et al. CD106 and activated-CD29 are expressed on myelomatous bone marrow plasma cells and their downregulation is associated with tumour progression. Br J Haematol 2002 119 : 70 8.
39. Davies J, Warwick J, Totty N, Philp R, Helfrich M, Horton M. The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor. J Cell Biol 1989 109 : 1817 26.
40. Helfrich MH, Nesbitt SA, Lakkakorpi PT, Barnes MJ, Bodary SC, Shankar G, Mason WT, Mendrick DL, Vaananen HK, Horton MA. Beta 1 integrins and osteoclast function: involvement in collagen recognition and bone resorption. Bone 1996 19 : 317 28.
41. Michigami T, Shimizu N, Williams PJ, Niewolna M, Dallas SL, Mundy GR, Yoneda T. Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and alpha(4)beta(1)-integrin enhances production of osteoclast- stimulating activity. Blood 2000 96 : 1953 60.
42. Pearse RN, Sordillo EM, Yaccoby S, Wong BR, Liau DF, Colman N, Michaeli J, Epstein J, Choi Y. Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression. Proc Natl Acad Sci USA 2001 98 : 11581 6.
43. Mori Y, Shimizu N, Dallas M, Niewolna M, Story B, Williams PJ, Mundy GR, Yoneda T. Anti-alpha4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysis. Blood 2004 104 : 2149 54.