Syndecan-1 is targeted to the uropods of polarized myeloma cells where it promotes adhesion and sequesters heparin-binding proteins

Blood

Volumn 96, Issue 7, 2000, Pages 2528-2536

  Borset, M ^a   Hjertner, O ^a   Yaccoby, S ^a   Epstein, J ^a   Sanderson, R D ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARAN SULFATE; HEPARIN BINDING PROTEIN; HERMES ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; OSTEOPROTEGERIN; PROTEOGLYCAN; SCATTER FACTOR; SYNDECAN; SYNDECAN 1; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CELL AGGREGATION; CELL MIGRATION; CELL POLARITY; CELL STRUCTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MYELOMA CELL; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

EID: 0034307372     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.7.2528     Document Type: Article

References (37)

1. Expression of syndecan-1 inhibits cell invasion into type I collagen
2. Expression of syndecan regulares human myeloma plasma cell adhesion to type I collagen
3. Heparan sulfate-mediated cell aggregation: Syndecans-1 and -4 mediate intercellular adhesion following their transfection into human B lymphoid cells
4. Multiple myeloma: Increasing evidence for a multistep transformation process
5. Circulating clonal lymphocytes in myeloma constitute a minor subpopulation of B-cells
6. Monoclonal circulating B cells in multiple myeloma: A continuously differentiating, possibly invasive, population as defined by expression of CD45 isoforms and adhesion molecules
7. Cellular polarization induced by chemokines: A mechanism for leukocyte recruitment?
8. Leukocyte polarization in cell migration and immune interactions
9. Redistribution of myosin accompanying capping of surface lg
10. Spontaneous redistribution of surface immunoglobulin in the motile B lymphocyte
11. Association of intercellular adhesion molecule-1 (ICAM-1) with actin-containing cytoskeleton and alpha-actinin
12. ICAMs redistributed by chemokines to cellular uropods as a mechanism for recruitment of T lymphocytes
13. Chemokines regulate cellular polarization and adhesion receptor redistribution during lymphocyte interaction with endothelium and extracellular matrix: Involvement of cAMP signaling pathway
14. CD43 interacts with moesin and ezrin and regulares its redistribution to the uropods of T lymphocytes at the cell-cell contacts
15. Concomitant expression of hepatocyte growth factor/scatter factor and its receptor c-Met in human myeloma cell lines
16. Immunocytochemistry of cell surface heparan sulfate proteoglycan in mouse tissues: A light and electron microscopic study
17. Syndecan-1 is a multifunctional regulator of myeloma pathobiology: Control of tumor cell survival, growth, and bone cell differentiation
18. Regulatory role of CD43 leukosialin on integrin-mediated T-cell adhesion to endothelial and extracellular matrix ligands and its polar redistribution to a cellular uropod
19. A plasmocyte selective monoclonal antibody (B-B4) recognizes syndecan-l
20. Characterization of adhesion molecules on human myeloma cell lines
21. Production of fibronectin and adherence to fibronectin by human myeloma cell lines
22. Heparin modulates the receptor-binding and mitogenic activity of hepatocyte growth factor on hepatocytes
23. Characterization of structural domains of human osteoclastogenesis inhibitory factor
24. Developmental changes in heparan sulfate expression: In situ detection with mAbs
25. Leukosialin (CD43, sialophorin) redistribution in uropods of polarized neutrophils is induced by CD43 cross-linking by antibodies, by colchicine or by chemotactic peptides
26. The chemokine SDF-1alpha triggers a chemotactic response and induces cell polarization in human B lymphocytes
27. Syndecan-1 (CD 138) in myeloma and lymphoid malignancies: A multifunctional regulator of cell behavior within the tumor microenvironment
28. Serum syndecan-l: A new independent prognostic marker in multiple myeloma
29. Homotypic cell aggregations of human myeloma cells with ICAM-1 and LFA-1 molecules
30. Hepatocyte growth factor and its receptor c-Met in multiple myeloma
31. Elevated serum concentrations of hepatocyte growth factor in patients with multiple myeloma
32. Hepatocyte growth factor (HGF) induces interleukin-11 secretion from osteoblasts: A possible role for HGF in myeloma-associated osteolytic bone disease
33. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
34. Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
35. Hand-mirror cell leukemia: Report of nine cases and a review of the literature
36. Hyaluronan-dependent motility of B cells and leukemic plasma cells in blood, but not of bone marrow plasma cells, in multiple myeloma: Alternate use of receptor for hyaluronan-mediated motility (RHAMM) and CD44
37. Morphological evidence for a motile behavior by plasma cells