Synthesis and antitumor activity of C3 heterocyclic-substituted fluoroquinolone derivatives (I) : Ciprofloxacin aminothiodiazole Schiff-bases

Yaoxue Xuebao

Volumn 43, Issue 11, 2008, Pages 1112-1115

  Hu, Guo Qiang ^a   Wu, Xiao Kui ^a   Wang, Xin ^a   Zhang, Zhi Qiang ^a   Xie, Song Qiang ^a   Huang, Wen Long ^b   Zhang, Hui Bin ^b  

^a HENAN UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Antitumor activity; Fluoroquinolone; Schiff base; Thiadiazole

Indexed keywords

ANTINEOPLASTIC AGENT; CIPROFLOXACIN; DRUG DERIVATIVE; SCHIFF BASE;

ANIMAL; ARTICLE; CELL STRAIN HL 60; DRUG EFFECT; DRUG SCREENING; HUMAN; IC 50; LEUKEMIA L 1210; LIVER TUMOR; PATHOLOGY; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CIPROFLOXACIN; DRUG SCREENING ASSAYS, ANTITUMOR; HL-60 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LEUKEMIA L1210; LIVER NEOPLASMS; SCHIFF BASES;

EID: 56649109508     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Katsarou ME, Efthimiadou EK, Psomas G, et al. Novel copper (II) complex of N-propyl-norfloxacin and 1,10-phenanthroline with enhanced antileukemic and DNA nuclease activities [J]. J Med Chem, 2008,51:470-478.
2. Giannini G, Marzi M, Cabri W, et al. E-ring-modified 7-oxyiminomethyl camptothecins: synthesis and preliminary in vitro and in vivo biological evaluation [J]. Bioorg Med Chem Lett, 2008,18:2910-2915.
3. Wang XT, Zhang JB, Lei YJ. An advance of study in antitumor quinolone drugs [J]. Chin Pharm J, 2004,39:890-894.
4. Hu GQ, Xie SQ, Du GJ, et al. Synthesis and bioactivity of water-soluble fused s-triazolo-thiadiazole systems (II): fluoroquinolone piperazine derivatives [J]. Acta Chim Sin , 2008(in press).
5. Hu GQ, Wu XK, Xie SQ, et al. Design, synthesis and antitumor activity of asymmetric bis(Schiff-base)s (II): bearing quinolone, s-triazole and thiosemicarbazone moieties [J]. Chin Chem, 2008(in press).
6. Rzeski W, Matysiak J, Kandefer-Szerszeń M. Anticancer, neuroprotective activities and computational studies of 2-amino-1, 3, 4-thiadiazole based compound [J]. Bioorg Med Chem, 2007,15:3201-3207.
7. Barve V, Ahmed F, Adsule S, et al. Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells [J]. J Med Chem, 2006,49:3800-3808.
8. Qi CM, Chen WY, Yang LC, et al. Synthesis and hybridizing activity of novel chemical hybridizing agent pyridazinone derivatives [J]. Chin J Org Chem , 2004,24:645-649.
9. Xie SQ, Hu GQ, Zhang ZQ, et al. Anti-tumour effects of HL-37, a novel anthracene derivative, in vivo and in vitro [J]. J Pharm Pharmacol, 2008,60:213-219.