Simultaneous detection of JAK2 V617F mutation and Bcr-Abl translocation in a patient with chronic myelogenous leukemia

International Journal of Hematology

Volumn 88, Issue 2, 2008, Pages 243-245

  De Conchon, Monika Ribeiro Mello ^a   Costa, Juliana Lima ^a   Novaes, Mafalda Megumi Yoshinaga ^a   Dorlhiac Llacer, Pedro Enrique ^a   De Alencar Fischer Chamone, Dalton ^a   Bendit, Israel ^a,b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Department of the Tumor Biology Laboratory ^*  (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; HYDROXYUREA; IMATINIB; JANUS KINASE 2; RETICULIN;

ADULT; BLOOD SAMPLING; BONE MARROW BIOPSY; CANCER PATIENT; CASE REPORT; CHROMOSOME ANALYSIS; CHROMOSOME TRANSLOCATION; CHRONIC MYELOID LEUKEMIA; CLINICAL FEATURE; CLONE; DNA SEQUENCE; FEMALE; GENE MUTATION; HOMOZYGOSITY; HOSPITAL ADMISSION; HUMAN; LABORATORY TEST; LETTER; LEUKOCYTE COUNT; METAPHASE; MUTATIONAL ANALYSIS; MYELOFIBROSIS; PHILADELPHIA CHROMOSOME POSITIVE CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SOMATIC MUTATION; SPLENOMEGALY; THROMBOCYTE COUNT; WEIGHT REDUCTION;

CHROMOSOME ABERRATIONS; FEMALE; FUSION PROTEINS, BCR-ABL; GENETIC SCREENING; HUMANS; JANUS KINASE 2; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MIDDLE AGED; POINT MUTATION; TRANSLOCATION, GENETIC;

EID: 56649102281     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12185-008-0131-2     Document Type: Letter

References (7)

1. LM Scott PJ Campbell EJ Baxter 2005 The V617F JAK2 mutation is uncommon in cancers and in myeloid malignancies other than the classic myeloproliferative disorders Blood 106 2920 1
2. A Kramer A Reiter J Kruth 2007 JAK2-V617F mutation in a patient with Philadelphia-chromosome-positive chronic myeloid leukaemia Lancet Oncol 8 658 60
3. K Hussein O Bock A Seegers M Flasshove 2007 Myelofibrosis evolving during imatinib treatment of a chronic myeloproliferative disease with coexisting BCR-ABL translocation and JAK2V617F mutation Blood 109 4106 7
4. EJ Baxter LM Scott PJ Campbell 2005 Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders Lancet 365 1054 61
5. M Bornhauser B Mohr U Oelschlaegel 2007 Concurrent JAK2 (V617F) mutation and BCR-ABL translocation within committed myeloid progenitors in myelofibrosis Leukemia 21 1824 6
6. G Busche K Hussein O Bock H Kreipe 2007 Insights into JAK2-V617F mutation in CML Lancet Oncol 8 863 4
7. M Bocchia AM Vannucchi A Gozzetti 2007 Insights into JAK2-V617F mutation in CML Lancet Oncol 8 864 6