Insights into JAK2-V617F mutation in CML

Lancet Oncology

Volumn 8, Issue 10, 2007, Pages 864-866

  Bocchia, Monica ^a   Vannucchi, Alessandro M ^b   Gozzetti, Alessandro ^a   Guglielmelli, Paola ^b   Poli, Giada ^b   Crupi, Rosaria ^a   Defina, Marzia ^a   Bosi, Alberto ^b   Francesco, Lauria ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; IMATINIB; JANUS KINASE 2; PHENYLALANINE; VALINE;

ALLELE; BURST FORMING UNIT E; CHROMOSOME 18Q; CHROMOSOME 9P; CHROMOSOME ANALYSIS; CHRONIC MYELOID LEUKEMIA; COLONY FORMING UNIT GM; DISEASE DURATION; FLUORESCENCE IN SITU HYBRIDIZATION; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; LETTER; MOLECULAR CLONING; MUTATIONAL ANALYSIS; PHILADELPHIA CHROMOSOME POSITIVE CELL; PHLEBOTOMY; POLYCYTHEMIA VERA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

FUSION PROTEINS, BCR-ABL; HUMANS; JANUS KINASE 2; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MUTATION; RNA, MESSENGER;

EID: 34748868427     PISSN: 14702045     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1470-2045(07)70295-4     Document Type: Letter

References (6)

1. Krämer A., Reiter A., Kruth J., et al. JAK2-V617F mutation in a patient with Philadelphia-chromosome-positive chronic myeloid leukaemia. Lancet Oncol 8 (2007) 658-660
2. Larsen T., Hasselbalch H., Pallisgaard N., and Kerndrup G. A der(18)t(9;18)(p13;p11) and a der(9;18)(p10;q10) in polycythemia vera associated with a hyperproliferative phenotype in transformation to postpolycythemic myelofibrosis. Cancer Genet Cytogenet 172 (2007) 107-112
3. Bornhäuser M., Mohr B., Oelschlaegel U., et al. Concurrent JAK2(V617F) mutation and BCR-ABL translocation within committed myeloid progenitors in myelofibrosis. Leukemia 21 (2007) 1824-1826
4. Jelinek J., Oki Y., Gharibyan V., et al. JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia. Blood 106 (2005) 3370-3373
5. Inami M., Inokuchi K., Okabe M., et al. Polycythemia associated with the JAK2V617F mutation emerged during treatment of chronic myelogenous leukaemia. Leukemia 21 (2007) 1103-1104
6. Hussein K., Bock O., Seegers A., et al. Myelofibrosis evolving during imatinib treatment of a chronic myeloproliferative disease with coexisting BCR-ABL translocation and JAK2V617F mutation. Blood 109 (2007) 4106-4107