Does creatine supplementation improve the plasma lipid profile in healthy male subjects undergoing aerobic training?

Journal of the International Society of Sports Nutrition

Volumn 5, Issue , 2008, Pages

  Gualano, Bruno ^a   Ugrinowitsch, Carlos ^a   Artioli, Guilherme G ^a   Benatti, Fabiana B ^a   Scagliusi, Fernanda B ^a   Harris, Roger C ^b   Lancha Jr , Antonio H ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF CHICHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 56649083274     PISSN: None     EISSN: 15502783     Source Type: Journal    
DOI: 10.1186/1550-2783-5-16     Document Type: Article

References (32)

1. Bender A Koch W Elstner M Schombacher Y Bender J Moeschl M Gekeler F Muller-Myhsok B Gasser T Tatsch K Klopstock T Creatine supplementation in Parkinson disease: A placebo-controlled randomized pilot trial Neurology 2006, 67(7):1262-1264 10.1212/01.wnl.0000238518.34389.12 17030762
2. Ferrante RJ Andreassen OA Jenkins BG Dedeoglu A Kuemmerle S Kubilus JK Kaddurah-Daouk R Hersch SM Beal MF Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease J Neurosci 2000, 20:(12):4389-4397 10844007
3. Gualano B Novaes RB Artioli GG Freire TO Coelho DF Scagliusi FB Rogeri PS Roschel H Ugrinowitsch C Lancha AH Jr Effects of creatine supplementation on glucose tolerance and insulin sensitivity in sedentary healthy males undergoing aerobic training Amino Acids 2008, 34(2):245-250 10.1007/s00726-007-0508-1 17396216
4. Kreider RB Ferreira M Wilson M Grindstaff P Plisk S Reinardy J Cantler E Almada AL Effects of creatine supplementation on body composition, strength, and sprint performance Med Sci Sports Exerc 1998, 30(1):73-82 9475647
5. Arciero PJ Hannibal NS 3rd Nindl BC Gentile CL Hamed J Vukovich MD Comparison of creatine ingestion and resistance training on energy expenditure and limb blood flow Metabolism 2001, 50(12):1429-1434 10.1053/meta.2001.28159 11735088
6. Kreider RB Melton C Rasmussen CJ Greenwood M Lancaster S Cantler EC Milnor P Almada AL Long-term creatine supplementation does not significantly affect clinical markers of health in athletes Mol Cell Biochem 2003, 244(1-2):95-104 10.1023/A:1022469320296 12701816
7. Earnest CP Almada AL Mitchell TL High-performance capillary electrophoresis-pure creatine monohydrate reduces blood lipids in men and women Clin Sci (Lond) 1996, 91(1):113-118 8774269
8. Reaven GM Role of insulin resistance in human disease (syndrome X): An expanded definition Annu Rev Med 1993, 44:121-131 10.1146/ annurev.me.44.020193.001005 8476236
9. Reaven GM Compensatory hyperinsulinemia and the development of an atherogenic lipoprotein profile: The price paid to maintain glucose homeostasis in insulin-resistant individuals Endocrinol Metab Clin North Am 2005, 34(1):49-62 10.1016/j.ecl.2004.12.001 15752921
10. Einhorn D Reaven GM Cobin RH Ford E Ganda OP Handelsman Y Hellman R Jellinger PS Kendall D Krauss RM Neufeld ND Petak SM Rodbard HW Seibel JA Smith DA Wilson PW American College of Endocrinology position statement on the insulin resistance syndrome Endocr Pract 2003, 9(3):237-252 12924350
11. Pedersen BK Saltin B Evidence for prescribing exercise as therapy in chronic disease Scand J Med Sci Sports 2006, 16(Suppl):1-3 63 10.1111/ j.1600-0838.2006.00520.x 16451303
12. Walsh B Tonkonogi M Soderlund K Hultman E Saks V Sahlin K The role of phosphorylcreatine and creatine in the regulation of mitochondrial respiration in human skeletal muscle J Physiol 2001, 537(Pt 3):971-978 2278998 11744769 10.1113/jphysiol.2001.012858
13. Wyss M Schlegel J James P Eppenberger HM Wallimann T Mitochondrial creatine kinase from chicken brain. Purification, biophysical characterization, and generation of heterodimeric and heterooctameric molecules with subunits of other creatine kinase isoenzymes J Biol Chem 1990, 265(26):15900-15908 2394753
14. Ellington WR Evolution and physiological roles of phosphagen systems Annu Rev Physiol 2001, 63:289-325 10.1146/annurev.physiol.63.1.289 11181958
15. Harris RC Soderlund K Hultman E Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation Clin Sci (Lond) 1992, 83(3):367-374 1327657
16. Hultman E Soderlund K Timmons JA Cederblad G Greenhaff PL Muscle creatine loading in men J Appl Physiol 1996, 81(1):232-237 8828669
17. Matthews DR Hosker JP Rudenski AS Naylor BA Treacher DF Turner RC Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 1985, 28(7):412-419 10.1007/BF00280883 3899825
18. Volek JS Duncan ND Mazzetti SA Putukian M Gomez AL Kraemer WJ No effect of heavy resistance training and creatine supplementation on blood lipids Int J Sport Nutr Exerc Metab 2000, 10(2):144-156 10861335
19. Zwang L Blijenberg BG Assessment of a selected method for creatinine with special emphasis on bilirubin interference Eur J Clin Chem Clin Biochem 1991, 29(12):795-800 1797104
20. Beaver WL Wasserman K Whipp BJ A new method for detecting anaerobic threshold by gas exchange J Appl Physiol 1986 60 6 2020 2027 3087938
21. Kaplan RS Pedersen PL Sensitive protein assay in presence of high levels of lipid Methods Enzymol 1989, 172:393-399 10.1016/S0076-6879(89)72025-5 2747536
22. Finley PR Schifman RB Williams RJ Lichti DA Cholesterol in high-density lipoprotein: Use of Mg2+/dextran sulfate in its enzymic measurement Clin Chem 1978, 24(6):931-933 207463
23. Ugrinowitsch C Fellingham GW Ricard MD Limitations of ordinary least squares models, in analyzing repeated measures data Med Sci Sports Exerc 2004, 36(12):2144 -148 10.1249/01.MSS.0000147580.40591.75 15570152
24. Littell RC Milliken GA Stroup WW Wolfinger RD Schabenberger O SAS system for mixed models SAS Institute 2006
25. Terjung RL Clarkson P Eichner ER Greenhaff PL Hespel PJ Israel RG Kraemer WJ Meyer RA Spriet LL Tarnopolsky MA Wagenmakers AJ Williams MH American College of Sports Medicine roundtable. The physiological and health effects of oral creatine supplementation Med Sci Sports Exerc 2000, 32(3):706-717 10.1097/00005768-200003000-00024 10731017
26. Kraus WE Houmard JA Duscha BD Knetzger KJ Wharton MB McCartney JS Bales CW Henes S Samsa GP Otvos JD Kulkarni KR Slentz CA Effects of the amount and intensity of exercise on plasma lipoproteins N Engl J Med 2002, 347(19):1483-1492 10.1056/NEJMoa020194 12421890
27. Halbert JA Silagy CA Finucane P Withers RT Hamdorf PA Exercise training and blood lipids in hyperlipidemic and normolipidemic adults: A meta-analysis of randomized, controlled trials Eur J Clin Nutr 1999, 53(7):514-522 10.1038/sj.ejcn.1600784 10452405
28. van Loon LJ Murphy R Oosterlaar AM Cameron-Smith D Hargreaves M Wagenmakers AJ Snow R Creatine supplementation increases glycogen storage but not GLUT-4 expression in human skeletal muscle Clin Sci (Lond) 2004, 106(1):99-106 14507259
29. Newman JE Hargreaves M Garnham A Snow RJ Effect of creatine ingestion on glucose tolerance and insulin sensitivity in men Med Sci Sports Exerc 2003, 35(1):69-74 10.1097/00005768-200301000-00012 12544638
30. Op 't Eijnde B Urso B Richter EA Greenhaff PL Hespel P Effect of oral creatine supplementation on human muscle GLUT4 protein content after immobilization Diabetes 2001, 50(1):18-23 10.2337/diabetes.50.1.18 11147785
31. Op't Eijnde B Jijakli H Hespel P Malaisse WJ Creatine supplementation increases soleus muscle creatine content and lowers the insulinogenic index in an animal model of inherited type 2 diabetes Int J Mol Med 2006, 17(6):1077-1084 16685419
32. Durstine JL Grandjean PW Davis PG Ferguson MA Alderson NL DuBose KD Blood lipid and lipoprotein adaptations to exercise: A quantitative analysis Sports Med 2001, 31(15):1033-1062 10.2165/ 00007256-200131150-00002 11735685