Corneal Ectasia After Excimer Laser Keratorefractive Surgery: Histopathology, Ultrastructure, and Pathophysiology

Ophthalmology

Volumn 115, Issue 12, 2008, Pages

  Dawson, Daniel G ^a,b   Randleman, J Bradley ^a   Grossniklaus, Hans E ^a   O'Brien, Terrence P ^b   Dubovy, Sander R ^b   Schmack, Ingo ^a,c   Stulting, R Doyle ^a   Edelhauser, Henry F ^a  

^a EMORY EYE CENTER   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CORNEA; CORNEA THICKNESS; CORNEA TRANSPLANTATION; CORNEAL ECTASIA; DISEASE COURSE; EXCIMER LASER; EYE DISEASE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPOPLASIA; KERATOCONUS; KERATOMILEUSIS; MICROSCOPY; PATHOPHYSIOLOGY; PHOTOREFRACTIVE KERATECTOMY; POSTOPERATIVE CARE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; REFRACTIVE SURGERY; RETROSPECTIVE STUDY; SCAR FORMATION; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

EID: 56549110650     PISSN: 01616420     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ophtha.2008.06.008     Document Type: Article

References (45)

1. Binder P.S., Lindstrom R.L., Stulting R.D., et al. Keratoconus and corneal ectasia after LASIK. J Cataract Refract Surg 31 (2005) 2035-2038
2. Randleman J.B. Post-laser in-situ keratomileusis ectasia: current understanding and future directions. Curr Opin Ophthalmol 17 (2006) 406-412
3. Seiler T., Koufala K., and Richter G. Iatrogenic keratectasia after laser in situ keratomileusis. J Refract Surg 14 (1998) 312-317
4. Randleman J.B., Woodward M., Lynn M.J., and Stulting R.D. Risk assessment for ectasia after corneal refractive surgery. Ophthalmology 115 (2008) 37-50
5. Geggel H.S., and Talley A.R. Delayed onset keratectasia following laser in situ keratomileusis. J Cataract Refract Surg 25 (1999) 582-586
6. Argento C., Cosentino M.J., Tytiun, et al. Corneal ectasia after laser in situ keratomileusis. J Cataract Refract Surg 27 (2001) 1440-1448
7. Jabbur N.S., Stark W.J., and Green W.R. Corneal ectasia after laser-assisted in situ keratomileusis. Arch Ophthalmol 119 (2001) 1714-1716
8. Spirn M.J., Dawson D.G., Rubinfeld R.S., et al. Histopathological analysis of post-laser-assisted in situ keratomileusis corneal ectasia with intrastromal corneal ring segments. Arch Ophthalmol 123 (2005) 1604-1607
9. Kim H., Song I.K., and Joo C.K. Keratectasia after laser in situ keratomileusis: clinicopathological case report. Ophthalmologica 220 (2006) 58-64
10. Kim H., Choi J., and Joo C. Corneal ectasia after PRK: clinicopathologic case report. Cornea 25 (2006) 845-848
11. Dawson D.G., Edelhauser H.F., and Grossniklaus H.E. Long-term histopathologic findings in human corneal wounds after refractive surgical procedures. Am J Ophthalmol 139 (2005) 168-178
12. Dawson D.G., Kramer T.R., Grossniklaus H.E., et al. Histologic, ultrastructural, and immunofluorescent evaluation of human laser-assisted in situ keratomileusis corneal wounds. Arch Ophthalmol 123 (2005) 741-756
13. Schmack I., Dawson D.G., McCarey B.E., et al. Cohesive tensile strength of human LASIK wounds with histologic, ultrastructural, and clinical correlation. J Refract Surg 21 (2005) 433-445
14. Dawson D.G., Holley G.P., Geroski D.H., et al. Ex vivo confocal microscopy of human LASIK corneas with histologic and ultrastructural correlation. Ophthalmology 112 (2005) 634-644
15. Randleman J.B., Dawson D.G., Grossniklaus H.E., et al. Depth-dependent cohesive tensile strength in human donor corneas: implications for refractive surgery. J Refract Surg 24 (2008) S85-S89
16. Dawson D.G., Grossniklaus H.E., McCarey B.E., and Edelhauser H.F. Biomechanical and wound healing characteristics of corneas after excimer laser keratorefractive surgery: is there a difference between advanced surface ablation and sub-Bowman's layer keratomileusis?. J Refract Surg 24 (2008) S90-S96
17. Maurice D.M. Mechanics of the cornea. In: Cavanagh H.D. (Ed). The Cornea: Transactions of the World Congress on the Cornea III (1988), Raven Press, New York 187-193
18. McPhee T.J., Bourne W.M., and Brubaker R.F. Location of the stress-bearing layers on the cornea. Invest Ophthalmol Vis Sci 26 (1985) 869-872
19. Baer E. Basic properties and responses of corneal biomechanics. In: McNicol L.A., and Strahlman E. (Eds). Corneal Biomechanics and Wound Healing: proceedings; Workshop on Corneal Biophysics I (1989), National Eye Institute, Bethesda, MD 65-84
20. Reifsnieder K.L. Assumptions and stress measurements of corneal biomechanics. In: McNicol L.A., and Strahlman E. (Eds). Corneal Biomechanics and Wound Healing: proceedings; Workshop on Corneal Biophysics I (1989), National Eye Institute, Bethesda, MD 85-100
21. Krasnov M.M. Corneal wound healing: clinical effects of corneal surgery. In: McNicol L.A., and Strahlman E. (Eds). Corneal Biomechanics and Wound Healing: proceedings; Workshop on Corneal Biophysics I (1989), National Eye Institute, Bethesda, MD 157-160
22. Hiltner A., Cassidy J.J., and Baer E. Mechanical properties of biological polymers. Annu Rev Mater Sci 15 (1985) 455-482
23. Silver F.H., Kato Y.P., Ohno M., and Wasserman A.J. Analysis of mammalian connective tissue: relationship between hierarchical structures and mechanical properties. J Long Term Eff Med Implants 2 (1992) 165-198
24. Provenzano P.P., and Vanderby Jr. R. Collagen fibril morphology and organization: implications for force transmission in ligament and tendon. Matrix Biol 25 (2006) 71-84
25. Bron A.J. The architecture of the corneal stroma. Br J Ophthalmol 85 (2001) 379-381
26. Bron A.J. Keratoconus. Cornea 7 (1988) 163-169
27. Polack F.M. Contributions of electron microscopy to the study of corneal pathology. Surv Ophthalmol 20 (1976) 375-414
28. Patey A., Salvoldelli M., and Pouliquen Y. Keratoconus and normal cornea: a comparative study of the collagenous fibers of the corneal stroma by image analysis. Cornea 3 (1984) 119-124
29. Pouliquen Y. Doyne lecture keratoconus. Eye 1 (1987) 1-14
30. Daxer A., and Fratzl P. Collagen fibril orientation in the human corneal stroma and its implication in keratoconus. Invest Ophthalmol Vis Sci 38 (1997) 121-129
31. Meek K.M., Tuft S.J., Huang Y., et al. Changes in collagen orientation and distribution in keratoconus corneas. Invest Ophthalmol Vis Sci 46 (2005) 1948-1956
32. Hayes S., Boote C., Tuft S.J., et al. A study of corneal thickness, shape, and collagen organisation in keratoconus using videokeratography and X-ray scattering techniques. Exp Eye Res 84 (2007) 423-434
33. Smolek M.K., and Kylce S.D. Is keratoconus a true ectasia?. An evaluation of corneal surface area. Arch Ophthalmol 118 (2000) 1179-1186
34. Dawson D.G., Watsky M.A., Geroski D.H., and Edelhauser H.F. Cornea and sclera. In: Tasman W., and Jaeger E.A. (Eds). Duane's Foundation of Clinical Ophthalmology [book on CD-ROM]. vol. 2. Physiology of the Eye and Visual System (2006), Lippincott Williams & Wilkins, Philadelphia, PA chapter 4
35. Komai Y., and Ushiki T. The three-dimensional organization of collagen fibrils in the human cornea and sclera. Invest Ophthalmol Vis Sci 32 (1991) 2244-2258
36. Radner W., and Mallinger R. Interlacing of collagen lamellae in the midstroma of human cornea. Cornea 21 (2002) 598-601
37. Hirsch M., Prenant G., and Renard G. Three-dimensional supramolecular organization of the extracellular matrix in human and rabbit corneal stroma, as revealed by ultrarapid-freezing and deep-etching methods. Exp Eye Res 72 (2001) 123-135
38. Provenzano P.P., Heisey D., Hayashi K., et al. Subfailure damage in ligament: a structural and cellular evaluation. J Appl Physiol 92 (2002) 362-371
39. Ellsmere J.C., Khanna R.A., and Lee J.M. Mechanical loading of bovine pericardium accelerates enzymatic degradation. Biomaterials 20 (1999) 1143-1150
40. Morishige N., Petroll W.M., Nishida T., et al. Noninvasive corneal stromal collagen imaging using two-photon-generated second-harmonic signals. J Cataract Refract Surg 32 (2006) 1784-1791
41. Morshige N., Wahlert A.J., Kenney M.C., et al. Second-harmonic imaging microscopy of normal human and keratoconus cornea. Invest Ophthalmol Vis Sci 48 (2007) 1087-1094
42. Radner W., Zehetmayer M., Skorpik C., and Mallinger R. Altered organization of collagen in the apex of keratoconus corneas. Ophthalmic Res 30 (1998) 327-332
43. Knops M., and Bogle C. Gradual failure of fibre/polymer laminates. Composites Sci Technol 66 (2006) 616-625
44. Ambrosio Jr. R., Alonso R.S., Luz A., and Coca Velarde L.G. Corneal-thickness spatial profile and corneal-volume distribution: tomographic indices to detect keratoconus. J Cataract Refract Surg 32 (2006) 1851-1859
45. Eliason J., and Maurice D. Stress distribution across the in vivo human cornea. Invest Ophthalmol Vis Sci [supplement] 20 (1981) 156