Reduction of porphyrins to porphyrinogens with palladium on carbon

Analytical Biochemistry

Volumn 384, Issue 1, 2009, Pages 74-78

  Bergonia, Hector A ^a   Phillips, John D ^a   Kushner, James P ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Heme biosynthetic pathway; HPLC; Porphyria; Porphyrin; Porphyrinogen; Uroporphyrinogen decarboxylase

Indexed keywords

ALKALINITY; BIOSYNTHESIS; CARBON; ENZYMES; INERT GASES; IONIC STRENGTH; PALLADIUM; SODIUM BOROHYDRIDE;

BIOSYNTHETIC PATHWAY; DECARBOXYLASES; HPLC; PORPHYRIA; PORPHYRINOGEN;

PORPHYRINS;

CARBON; HYDROGEN; INERT GAS; PALLADIUM; PORPHOBILINOGEN; PORPHYRIN; PORPHYRINOGEN; SODIUM BOROHYDRIDE;

ARTICLE; CATALYST; ENVIRONMENTAL TEMPERATURE; FILTRATION; HEME SYNTHESIS; HYDROGENATION; PRIORITY JOURNAL; REDUCTION;

EID: 56549109912     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2008.09.027     Document Type: Article

References (12)

1. Smith K.M. Porphyrins and Metalloporphyrins (1976), Elsevier North Holland Medical Press, Amsterdam
2. Phillips J.D., Whitby F.G., Kushner J.P., and Hill C.P. Structural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylase. EMBO J. 22 (2003) 6225-6233
3. Straka J.G., Kushner J.P., and Pryor M.A. Uroporphyrinogen decarboxylase: a method for measuring enzymatic activity. Enzyme 28 (1982) 170-185
4. Conant J.B., and Hyde J.F. Studies in the chlorophyll series: II. Reduction and catalytic hydrogenation. J. Am. Chem. Soc. 52 (1930) 1233-1239
5. Fischer H., and Zerweck W. The natural porphyrins: VIII. Uroporphyrinogen heptamethyl ester and a new conversion of uro- into coproporphyrin. Z. Physiol. Chem. 137 (1924) 242-264
6. Blanchard D.E. Quantitative microscale hydrogenation of vegetable oils. J. Chem. Educ. 80 (2003) 544-546
7. Sessler J.L., Johnson M.R., and Lynch V. Synthesis and crystal structure of a novel tripyrrane-containing porphyrinogen-like macrocycle. J. Org. Chem. 52 (1987) 4394-4397
8. Chen J.-S., Vasiliev A.N., Panarello A.P., and Khinast J.G. Pd-leaching and Pd-removal in Pd/C-catalyzed Suzuki couplings. Appl. Catalysis A 325 (2007) 76-86
9. Kielhorn J., Melber C., Keller D., and Mangelsdorf I. Palladium: a review of exposure and effects to human health. Intl. J. Hyg. Environ. Health 205 (2002) 417-432
10. Phillips J.D., Bergonia H.A., Reilly C.A., Franklin M.R., and Kushner J.P. A porphomethene inhibitor of uroporphyrinogen decarboxylase causes porphyria cutanea tarda. Proc. Natl. Acad. Sci. USA 104 (2007) 5079-5084
11. Phillips J.D., and Kushner J.P. Measurement of uroporphyrinogen decarboxylase activity. In: Maines M.D., Costa L.G., Reed D.J., Sassa S., and Sipes I.G. (Eds). Current Protocols in Toxicology (1999), John Wiley, New York 841-8413
12. Mathews M.A., Schubert H.L., Whitby F.G., Alexander K.J., Schadick K., Bergonia H.A., Phillips J.D., and Hill C.P. Crystal structure of human uroporphyrinogen III synthase. EMBO J. 20 (2001) 5832-5839