A porphomethene inhibitor of uroporphyrinogen decarboxylase causes porphyria cutanea tarda

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 12, 2007, Pages 5079-5084

  Phillips, John D ^a   Bergonia, Hector A ^a   Reilly, Christopher A ^a   Franklin, Michael R ^a   Kushner, James P ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Heme; Iron; Oxidation; Porphyrins

Indexed keywords

UNCLASSIFIED DRUG; UROPORPHOMETHENE; UROPORPHYRINOGEN; UROPORPHYRINOGEN DECARBOXYLASE; LIVER EXTRACT; PORPHYRIN; RECOMBINANT PROTEIN;

ALLELE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HEMOCHROMATOSIS; HUMAN; HUMAN TISSUE; LIVER BIOPSY; MASS SPECTROMETRY; MOUSE; NONHUMAN; OXIDATION; PORPHYRIA; PORPHYRIA CUTANEA TARDA; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; ULTRAVIOLET SPECTROSCOPY; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CYTOSOL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER; METABOLISM;

MURINAE; MUS;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOSOL; HUMANS; LIVER; LIVER EXTRACTS; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; PORPHYRIA CUTANEA TARDA; PORPHYRINS; RECOMBINANT PROTEINS; UROPORPHYRINOGEN DECARBOXYLASE; UROPORPHYRINOGENS;

EID: 34247558044     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0700547104     Document Type: Article

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