Medium throughput pKa determinations of drugs and chemicals by reverse phase HPLC with an organic gradient

Journal of Liquid Chromatography and Related Technologies

Volumn 29, Issue 15, 2006, Pages 2291-2301

  Chiang, Po Chang ^a   Foster, Kimberly ^a   Whittle, Marie ^a   Su, Ching Chiang ^a   Pretzer, Denise ^a  

^a PFIZER INC   (United States)

Author keywords

Drug substances; Medium throughput; Organic gradient; pKa; Reverse phase HPLC

Indexed keywords

COSTS; CROSSLINKING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PH EFFECTS; SENSITIVITY ANALYSIS;

DRUG SUBSTANCES; MEDIUM THROUGHPUT; ORGANIC GRADIENT; PKA; REVERSE PHASE HPLC;

DRUG PRODUCTS;

ACETYLSALICYLIC ACID; ALLOPURINOL; AMIODARONE; ATENOLOL; BENZOIC ACID; CEFADROXIL; CIMETIDINE; DICLOFENAC; DIPYRIDAMOLE; FENOFIBRATE; INDOLEACETIC ACID; KETOCONAZOLE; KETOPROFEN; LIDOCAINE; METOPROLOL; MINOXIDIL; NAPROXEN; PHENYTOIN; PROBENECID; PROPRANOLOL; QUININE; RANITIDINE; RESORUFIN; SALBUTAMOL; TENOXICAM; TERFENADINE; THEOPHYLLINE; TOLNAFTATE; UNINDEXED DRUG; WARFARIN;

ARTICLE; AUTOMATION; COST BENEFIT ANALYSIS; DISSOCIATION CONSTANT; DRUG DETERMINATION; HYDROPHILICITY; HYDROPHOBICITY; METHODOLOGY; PH; PURIFICATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SENSITIVITY ANALYSIS; SPECIES IDENTIFICATION; SPECTROSCOPY;

EID: 33746795350     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826070600832962     Document Type: Article

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