Neuromelanin-sensitive MRI: Basics, technique, and clinical applications

Clinical Neuroradiology

Volumn 18, Issue 3, 2008, Pages 147-153

  Sasaki, Makoto ^a   Shibata, Eri ^a   Kudo, Kohsuke ^a   Tohyama, Koujiro ^a  

^a IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

Locus caeruleus; Magnetic resonance imaging; Neuromelanin; Substantia nigra

Indexed keywords

CATECHOLAMINE; DOPAMINE; MONOAMINE; NEUROMELANIN; PIGMENT;

BRAIN STEM; CATECHOLAMINE SYNTHESIS; CELL NUCLEUS; CONTRAST ENHANCEMENT; DEGENERATIVE DISEASE; DEMENTIA; DEPRESSION; DOPAMINERGIC ACTIVITY; DOPAMINERGIC NERVE CELL; ELECTRON SPIN RESONANCE; HUMAN; LEWY BODY; LOCUS CERULEUS; MOOD DISORDER; NERVE CELL DEGENERATION; NEUROIMAGING; NORADRENERGIC NERVE; NUCLEAR MAGNETIC RESONANCE IMAGING; PARKINSON DISEASE; POLYMERIZATION; REPRODUCIBILITY; REVIEW; SCHIZOPHRENIA; SENSITIVITY ANALYSIS; SUBSTANTIA NIGRA;

EID: 56549090225     PISSN: 09397116     EISSN: 16156706     Source Type: Journal    
DOI: 10.1007/s00062-008-8018-4     Document Type: Review

References (30)

1. Crossman AR. Brain stem. In: Standring S, ed. Gray's anatomy: the anatomical basis of clinical practice, 39 edn. Edinburgh: Churchill Livingstone, 2005:327-51.
2. Sasaki M, Shibata E, Tohyama K, Takahashi J, Otsuka K, Tsuchiya K, Takahashi S, Ehara S, Terayama Y, Sakai A. Neuromelanin magnetic resonance imaging of locus ceruleus and substantia nigra in Parkinson's disease. Neuroreport 2006;31:1215-8.
3. Shibata E, Sasaki M, Tohyama K, Kanbara Y, Otsuka K, Ehara S, Sakai A. Age-related changes in the locus ceruleus on neuromelanin magnetic resonance imaging at 3 Tesla. Magn Reson Med Sci 2006;5:197-200.
4. Shibata E, Sasaki M, Tohyama K, Otsuka K, Sakai A. Reduced signal of locus ceruleus in depression in quantitative neuromelanin magnetic resonance imaging. Neuroreport 2007;18:415-8.
5. Shibata E, Sasaki M, Tohyama K, Otsuka K, Endoh J, Terayama Y, Sakai A. Use of neuromelanin-sensitive MRI to distinguish schizophrenic and depressive patients and healthy individuals based on signal alterations in the substantia nigra and locus ceruleus. Biol Psychiatry 2008:Epub ahead of print.
6. Fedorow H, Tribl F, Halliday G, Gerlach M, Riederer P, Double KL. Neuromelanin in human dopamine neurons: comparison with peripheral melanins and relevance to Parkinson's disease. Prog Neurobiol 2005;75:109-24.
7. Zecca L, Tampellini D, Gerlach M, Riederer P, Fariello RG, Sulzer D. Substantia nigra neuromelanin: structure, synthesis, and molecular behaviour. Mol Pathol 2001;54:414-8.
8. Zecca L, Zucca FA, Wilms H, Sulzer D. Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics. Trends Neurosci 2003;26:578-80.
9. Zecca L, Tampellini D, Gatti A, Crippa R, Eisner M, Sulzer D, Ito S, Fariello R, Gallorini M. The neuromelanin of human substantia nigra and its interaction with metals. J Neural Transm 2002;109:663-72.
10. Korytowski W, Sarna T, Zarba M. Antioxidant action of neuromelanin: the mechanism of inhibitory effect on lipid peroxidation. Arch Biochem Biophys 1995;319:142-8.
11. Fasano M, Bergamasco B, Lopiano L. Modifications of the iron-neuromelanin system in Parkinson's disease. J Neurochem 2006;96:909-16.
12. Tosk JM, Holshouser BA, Aloia RC, Hinshaw DB, Hasso AN, MacMurray JP, Will AD, Bozzetti LP. Effects of the interaction between ferric iron and L-dopa melanin on T1 and T2 relaxation times determined by magnetic resonance imaging. Magn Reson Med 1992;26:40-5.
13. Enochs WS, Petherick P, Boqdanova A, Mohr U, Weissleder R. Paramagnetic metal scavenging by melanin: MR imaging. Radiology 1997;204:417-23.
14. Wansapura JP, Holland SK, Dunn RS, Bass WS. NMR relaxation times in the human brain at 3.0 Tesla. J Magn Reson Imaging 1999;9:531-8.
15. Melki PS, Mulkern RV. Magnetization transfer effects in multislice RARE sequences. Magn Reson Med 1992;24:189-95.
16. Oikawa H, Sasaki M, Tamakawa Y, Ehara S, Tohyama K. The substantia nigra in Parkinson disease: proton density-weighted spin-echo and fast short inversion time inversion-recovery MR findings. AJNR Am J Neuroradiol 2002;23:1747-56.
17. Greenfield JG, Bosanquet FD. The brain stem lesion in parkinsonism. J Neurol Neurosurg Psychiatry 1953;16:213-25.
18. Wakabayashi K, Tanji K, Mori F, Takahashi H. The Lewy body in Parkinson's disease: molecules implicated in the formation and degradation of alpha-synuclein aggregates. Neuropathology 2007;27:494-506.
19. Rutledge JN, Hilal SK, Silver AJ, Defendini R, Fahrn S. Study of movement disorders and brain iron by MR. AJR Am J Roentgenol 1987;149:365-79.
20. Duguid JR, De La Paz R, DeGroot J. Magnetic resonance imaging of the midbrain in Parkinson's disease. Ann Neurol 1986;20:744-7.
21. Huber SJ, Chakeres DW, Paulson GW, Khanna R. Magnetic resonance imaging in Parkinson's disease. Arch Neurol 1990;47:735-7.
22. Stern MB, Braffman BH, Skolnick BE, Hurtig HI, Grossman RI. Magnetic resonance imaging in Parkinson's disease and parkinsonian syndromes. Neurology 1989;39:1524-6.
23. Zarow C, Lyness SA, Mortimer JA, Chui HCI. Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases. Arch Neurol 2003;60:337-41.
24. Siever LJ, Davis KL. Overview: Toward a dysregulation hypothesis of depression. Am J Psychiatry 1985;142:1017-31.
25. Mackay AV, Iversen LL, Rossor M, Spokes E, Bird E, Arregui A, Creese I, Synder SH. Increased brain dopamine and dopamine receptors in schizophrenia. Arch Gen Psychiatry 1982;39:991-7.
26. Alecci M, Collins CM, Smith MB, Jezzard P. Radio frequency magnetic field mapping of a 3 Tesla birdcage coil: experimental and theoretical dependence on sample properties. Magn Reson Med 2001;46:379-85.
27. Manaye KF, McIntire DD, Mann DM, German DC. Locus coeruleus cell loss in the aging human brain: a non-random process. J Comp Neurol 1995;358:79-97.
28. Zucca FA, Bellei C, Giannelli S, Terreni MR, Gallorini M, Rizzio E, Pezzoli G, Albertini A, Zecca L. Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability. J Neural Transm 2006;113:757-67.
29. Vymazal J, Righini A, Brooks RA, Canesi M, Mariani C, Leonardi M, Pezzoli G. T1 and T2 in the brain of healthy subjects, patients with Parkinson disease, and patients with multiple system atrophy: relation of iron content. Radiology 1999;211:489-95.
30. Tung CS, Ugedo L, Grenhoff J, Engberg G, Svensson TH. Peripheral induction of burst firing in locus coeruleus neurons by nicotine mediated via excitatory amino acids. Synapse 1989;4:313-8.