Effects of tissue type and the dose-death interval on the detection of acute ketamine exposure in bone and marrow with solid-phase extraction and ELISA with liquid chromatography-tandem mass spectrometry confirmation

Journal of Analytical Toxicology

Volumn 32, Issue 8, 2008, Pages 631-638

  Watterson, James H ^a   VandenBoer, Trevor C ^a  

^a LAURENTIAN UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

KETAMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW; BONE TISSUE; CONTROLLED STUDY; DIAPHYSIS; DRUG BONE LEVEL; DRUG EXPOSURE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIPHYSIS; FEMUR SHAFT; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; RAT; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

ANIMALIA; RATTUS;

EID: 56449119639     PISSN: 01464760     EISSN: 01464760     Source Type: Journal    
DOI: 10.1093/jat/32.8.631     Document Type: Article

References (15)

1. N. Raikos, H. Tsoukalia, and S.N. Njau. Determination of opiates in postmortem bone and bone marrow. Forensic Sci. Int. 123: 140-141 (2001).
2. E.L. Horak and A.J. Jenkins. Postmortem tissue distribution of olanzapine and citalopram in a drug intoxication. J. Forensic Sci. 50(3): 679-681 (2005).
3. K. Kudo, H. Sugie, N. Syoui, K. Kurihara, N. Jitsufuchi, T. Imamura, and N. Ikeda. Detection of triazolam in skeletal remains buried for 4 years. Int. J. Legal Med. 110: 281-283 (1997).
4. I. McIntyre, C.V. King, M. Boratto, and O. Drummer. Postmortem drug analyses in bone and bone marrow. Ther. Drug Monit. 22: 79-83 (2000).
5. L.Y. Gorczynski and F.J. Melbye. Detection of benzodiazepines in different tissues, including bone, using a quantitative ELISA assay. J. Forensic Sci. 46(4): 916-918 (2001).
6. E. Guillot, P. de Mazancourt, M. Durigon, and J.C. Alvarez. Morphine and 6-acetylmorphine concentrations in blood, brain, spinal cord, bone marrow and bone after lethal acute or chronic diacetylmorphine administration to mice. Forensic Sci. Int. 166: 139-147 (2007).
7. T. Kojima, I. Okamoto, T. Miyazaki, F. Chikasue, M. Yashiki, and K. Nakamura. Detection of methamphetamine and amphetamine in a skeletonized body buried for 5 years. Forensic Sci. Int. 31: 93-102 (1986).
8. C.L. Winek, A.G. Constantino, W.W. Wahba, and W.D. Collom. Blood versus bone marrow pentobarbital concentrations. Forensic Sci. Int. 27: 15-24 (1985).
9. A. Benkö. Toxicological analysis of amobarbital and glutethimide from bone tissue. J. Forensic Sci. 30(3): 708-714 (1985).
10. C.L. Winek, R.J. Matejczyk, and E.G. Buddie. Blood, bone marrow and eye fluid ethanol concentrations in putrefied rabbits. Forensic Sci. Int. 22: 151-159 (1983).
11. C.L. Winek, E.M. Morris, and W.W. Wahba. The use of bone marrow in the study of the postmortem redistribution of nortriptyline. J. Anal. Toxicol. 17: 93-98 (1993).
12. T.C. VandenBoer, S.A. Grummett, and J.H. Watterson. Utility of immunoassay in drug screening in skeletal tissues: sampling considerations in detection of ketamine exposure in femoral bone and bone marrow following acute administration using ELISA. J. Forensic Sci., in press.
13. M.L. Williams, D.E. Mager, H. Parenteau, G. Gudi, T.S. Tracy, M. Mulheran, and I.W. Wainer. Effects of protein calorie malnutrition on the pharmacokinetics of ketamine in rats. Drug Metab. Dispos. 32(8): 786-793 (2004).
14. T. Kupiec, L. DeCicco, V. Spiehler, G. Sneed, and P. Kemp. Choice of an ELISA assay for screening postmortem blood for amphetamine and/or methamphetamine. J. Anal. Toxicol. 26(7): 513-518 (2002).
15. P. Kemp, G. Sneed, T. Kupiec, and V. Spiehler. Validation of a microtiter plate ELISA for screening of postmortem blood for opiates and benzodiazepines. J. Anal. Toxicol. 26(7): 504-512 (2002).