Serotonin 5-HT2A receptor gene variants influence antidepressant response to repeated total sleep deprivation in bipolar depression

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 32, Issue 8, 2008, Pages 1863-1866

  Benedetti, Francesco ^a   Barbini, Barbara ^a   Bernasconi, Alessandro ^a   Fulgosi, Mara Cigala ^a   Colombo, Cristina ^a   Dallaspezia, Sara ^a   Gavinelli, Chiara ^a   Marino, Elena ^a   Pirovano, Adele ^a   Radaelli, Daniele ^a   Smeraldi, Enrico ^a  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

5 HT2A receptor; Bipolar disorder; Major depression; Serotonin; Sleep deprivation

Indexed keywords

ANTIDEPRESSANT AGENT; SEROTONIN; SEROTONIN 2A RECEPTOR; DRUG DERIVATIVE; MIANSERIN; MIRTAZAPINE; TRICYCLIC ANTIDEPRESSANT AGENT;

ADULT; ARTICLE; BIPOLAR I DISORDER; DRUG RESPONSE; EPIGENETICS; FEMALE; GENETIC POLYMORPHISM; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MOOD; NEUROTRANSMISSION; SELF REPORT; SLEEP DEPRIVATION; ANALYSIS OF VARIANCE; BIPOLAR DISORDER; GENETICS; MIDDLE AGED; PAIN ASSESSMENT; PSYCHOLOGICAL RATING SCALE; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT OUTCOME;

ADULT; ANALYSIS OF VARIANCE; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BIPOLAR DISORDER; FEMALE; HUMANS; MALE; MIANSERIN; MIDDLE AGED; PAIN MEASUREMENT; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHIATRIC STATUS RATING SCALES; RECEPTOR, SEROTONIN, 5-HT2A; SLEEP DEPRIVATION; TREATMENT OUTCOME;

EID: 56449112637     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2008.08.017     Document Type: Article

References (25)

1. Aitken R.C. Measurement of feelings using visual analogue scales. Proc R Soc Med. 62 (1969) 989-993
2. Benedetti F., Serretti A., Colombo C., Campori E., Barbini B., di Bella D., et al. Influence of a functional polymorphism within the promoter of the serotonin transporter gene on the effects of total sleep deprivation in bipolar depression. Am J Psychiatry 156 (1999) 1450-1452
3. Benedetti F., Barbini B., Colombo C., and Smeraldi E. Chronotherapeutics in a psychiatric ward. Sleep Med Rev 11 (2007) 509-522
4. Bönsch D., Hothorn T., Krieglstein C., Koch M., Nehmer C., Lenz B., et al. Daily variations of homocysteine concentration may influence methylation of DNA in normal healthy individuals. Chronobiol Int 24 (2007) 315-326
5. Bunney J.N., and Potkin S.G. Circadian abnormalities, molecular clock genes and chronobiological treatments in depression. Br Med Bull. 86 (2008) 23-32
6. Celada P., Puig M., Amargós-Bosch M., Adell A., and Artigas F. The therapeutic role of 5-HT1A and 5-HT2A receptors in depression. J Psychiatry Neurosci 29 (2004) 252-265
7. Hill T., and Lewicki P. Statistics: methods and applications. A comprehensive reference for science, industry, and data mining. Chapter 18. General Linear Models. StatSoft, Tulsa (OK) (2006) 245-276
8. Holmes A. Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease. Neurosci Biobehav Rev (2008) 10.1016/j.neubiorev.2008.03.006 Mar 26 [Electronic publication ahead of print]
9. Jokela M., Keltikangas-Järvinen L., Kivimäki M., Puttonen S., Elovainio M., Rontu R., et al. Serotonin receptor 2A gene and the influence of childhood maternal nurturance on adulthood depressive symptoms. Arch Gen Psychiatry 64 (2007) 356-360
10. Kang R.H., Choi M.J., Paik J.W., Hahn S.W., and Lee M.S. Effect of serotonin receptor 2A gene polymorphism on mirtazapine response in major depression. Int J Psychiatry Med 37 (2007) 315-329
11. Mann J.J., Brent D.A., and Arango V. The neurobiology and genetics of suicide and attempted suicide: a focus on the serotonergic system. Neuropsychopharmacology 24 (2001) 467-477
12. Meyer J.H., McMain S., Kennedy S.H., Korman L., Brown G.M., DaSilva J.N., et al. Dysfunctional attitudes and 5-HT2 receptors during depression and self-harm. Am J Psychiatry 160 (2003) 90-99
13. Morairty S.R., Hedley L., Flores J., Martin R., and Kilduff T.S. Selective 5HT2A and 5HT6 receptor antagonists promote sleep in rats. Sleep 31 (2008) 34-44
14. Norton N., and Owen M.J. HTR2A: association and expression studies in neuropsychiatric genetics. Ann Med 37 (2005) 121-129
15. Parsons M.J., D'Souza U.M., Arranz M.J., Kerwin R.W., and Makoff A.J. The - 1438A/G polymorphism in the 5-hydroxytryptamine type 2A receptor gene affects promoter activity. Biol Psychiatry 56 (2004) 406-410
16. Plante D.T., and Winkelman J.W. Sleep disturbance in bipolar disorder. Am J Psychiatry (2008) 10.1176/appi.ajp.2008.08010077 May 15. [Electronic publication ahead of print]
17. Polesskaya O.O., and Sokolov B.P. Differential expression of the "C" and "T" alleles of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics. J Neurosci Res. 67 (2002) 812-822
18. Polesskaya O.O., Aston C., and Sokolov B.P. Allele C-specific methylation of the 5-HT2A receptor gene: evidence for correlation with its expression and expression of DNA methylase DNMT1. J Neurosci Res 83 (2006) 362-373
19. Popa D., Léna C., Fabre V., Prenat C., Gingrich J., Escourrou P., et al. Contribution of 5-HT2 receptor subtypes to sleep-wakefulness and respiratory control, and functional adaptations in knock-out mice lacking 5-HT2A receptors. J Neurosci. 25 (2005) 11231-11238
20. Sanders-Bush E., Fentress H., and Hazelwood L. Serotonin 5-ht2 receptors: molecular and genomic diversity. Mol Interv 3 (2003) 319-330
21. Serretti A., Drago A., and De Ronchi D. HTR2A gene variants and psychiatric disorders: a review of current literature and selection of SNPs for future studies. Curr Med Chem 14 (2007) 2053-2069
22. Smeraldi E., Benedetti F., Barbini B., Campori C., and Colombo C. Sustained antidepressant effect of sleep deprivation combined with pindolol in bipolar depression: a placebo-controlled trial. Neuropsychopharmacology 20 (1999) 380-385
23. Stein D.J., Hemmings S., Moolman-Smook H., and Audenaert K. 5-HT2A: its role in frontally mediated executive function and related psychopathology. CNS Spectr 12 (2007) 512-516
24. Turecki G., Briere R., Dewar K., Antonetti T., Lesage A.D., Seguin M., et al. Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide. Am J Psychiatry 156 (1999) 1456-1458
25. Wirz-Justice A, Van den Hoofdakker RH. Sleep deprivation in depression: what do we know, where do we go? Biol Psychiatry 1999;46(4):445-53 [Review].