Overexpression of 15-lipoxygenase in the vascular endothelium is associated with increased thymic apoptosis in LDL receptor-deficient mice

Pathobiology

Volumn 71, Issue 5, 2004, Pages 261-266

  Afek, A ^a   Zurgil, N ^c   Bar Dayan, Y ^a   Polak Charcon, S ^a   Goldberg, I ^a   Deutsch, M ^c   Kopolovich, J ^a   Keren, G ^d   Harats, D ^b   George, J ^d,e  

^a Institute of Pathology   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

^c BAR ILAN UNIVERSITY   (Israel)

^d TEL AVIV UNIVERSITY   (Israel)

^e TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

Author keywords

15 lipoxygenase; Apoptosis; Atherosclerosis; Oxidation; Thymus

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; ARACHIDONATE 15 LIPOXYGENASE; CASPASE 3 INHIBITOR; LIPOCORTIN 5; LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; PROPIDIUM IODIDE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; CELL DEATH; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CYTOMETRY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MOUSE; NICK END LABELING; NONHUMAN; OXIDATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYMOCYTE; THYMUS; VASCULAR ENDOTHELIUM;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; APOPTOSIS; ARACHIDONATE 15-LIPOXYGENASE; CASPASE 3; CASPASES; CELLS, CULTURED; CLONAL DELETION; CYSTEINE PROTEINASE INHIBITORS; ENDOTHELIUM, VASCULAR; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; OLIGOPEPTIDES; RECEPTORS, LDL; T-LYMPHOCYTES; THYMUS GLAND;

SIGANUS;

EID: 5644267764     PISSN: 10152008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000080060     Document Type: Article

References (29)

1. Mehr R, Globerson A, Pederson A: Modeling positive and negative selection and differentiation process in the thymus. J Theor Biol 1995;175:103-126.
2. Surh C, Sprent J: T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 1994;372:100-103.
3. Bar-Dayan Y, Small M: Effect of bovine growth hormone administration on the pattern of thymic involution in mice. Thymus 1994;23:95-101.
4. Bar-Dayan Y, Blank M, Amital H, et al: Short term effects of high dose insulin on thymic morphology of ICR female mice. Diabetes Res 1997;32:27-35.
5. Bar-Dayan Y, Aronson M, Small M: Thymic aging in ICR female mice is suspended by prolonged hydrocortisone exposure. Cell Tissue Res 1997;290:609-613.
6. Juzan M, Hostein I, Gualde N: Role of thymus-eicosanoids in the immune response. Prostaglandins Leukot Essent Fatty Acids 1992;46:247-251.
7. Kuhn H, Barnett J, Grunberger D, Baecker P, Nguyen B, Bursztyn-Pettegrew H, Chan H, Sigal E: Overexpression, purification and characterization of human recombinant 15-lipoxygenase. Biochim Biophys Acta 1993;1169:80-89.
8. Kuhn H, Belkner J, Wiesner R, Brash AR: Oxygenation of biological membranes by the pure reticulocyte lipoxygenase. J Biol Chem 1990;65:18351-18361.
9. Murray JJ, Brash AR: Rabbit reticulocyte lipoxygenase catalyses specific 12(s) and 15(s) oxygenation of arachidononyl-phosphatidyl choline. Arch Biochem Biophys 1988;265:514-523.
10. Tang DG, Chen YQ, Honn KV: Arachidonic lipoxygenases as essential regulators of cell survival and apoptosis. Proc Natl Acad Sci USA 1996;93:5241-5246.
11. Ikawa H, Kamitani H, Calvo B, Foley J, Eling T: Expression of 15-lipoxygenase in human colorectal cancer. Cancer Res 1999;59:360-366.
12. Kamitani H, Ikawa H, His L, Watanabe T, DuBois R, Eling T: Regulation of 12-lipoxygenase in rat epithelial cells during differentiation and apoptosis induced by sodium butyrate. Arch Biochem Biophys 1999;368:45-55.
13. Parthasarathy S, Wieland E, Steinberg D: A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein. Proc Natl Acad Sci USA 1989;86:1046-1050.
14. Rankin SM, Parthasarathy S, Steinberg D: Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages. J Lipid Res 1991;32:449-456.
15. Hsieh C, Yen M, Yen H, Lau YT: Oxidised low density lipoprotein induces apoptosis via generation of reactive oxygen species in vascular smooth muscle cells. Cardiovasc Res 2001;49:135-145.
16. Gu J, Liu Y, Wen Y, Natarajan R, Lanting L, Nadler GL: Evidence that increased 12-lipoxygenase activity induces apoptosis in fibroblasts. J Cell Physiol 2001;186:357-365.
17. Lee T, Chau L: Fas/fas ligand-mediated cell death pathway is involved in oxLDL-induced apoptosis in vascular smooth muscle cells. Am J Physiol Cell Physiol 2001;280:C709-C718.
18. Harats D, Kurihara H, Belloni P, Oakley H, Ziober A, Ackley D, Cain G, Kurihara Y, Lawn R, Sigal E: Targeting gene expression to the vascular wall in transgenic mice using the murine preproendothelin-1 promoter. J Clin Invest 1995;95:1335-1344.
19. Ishibashi S, Brown MS, Goldstein JL, Gerard RD, Hammer RE, Herz J: Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest 1993;92:883-893.
20. Sun D, Funk CD: Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein. J Biol Chem 1996;271:24055-24062.
21. Harats D, Mulkins MA, Sigal E: A possible role for 15-lipoxygenase in atherosclerosis. Trends Cardiovasc Med 1995;5:29-36.
22. Kong J, Ringer D: Quantitative in situ image analysis of apoptosis in well and poorly differentiated tumors from rat liver. Am J Pathol 1995;147:1626-1632.
23. Bodi I, Abraham AA, Kimmel P: Apoptosis in human immunodeficiency virus-associated nephropathy. Am J Kidney Dis 1995;26:286-291.
24. Sunray M, Kaufman M, Zurgil N, Deutsch M: The trace and subgrouping of lymphocyte activation by dynamic fluorescence intensity and polarization measurements. Biochem Biophys Res Commun 1999;261:712-719.
25. Deutsch M, Kaufman M, Shapiro H, Zurgil N: Analysis of enzyme kinetics in individual living cells utilizing fluorescence intensity and polarization measurements. Cytometry 2000;39:36-44.
26. Tang DG, Guan KL, Li L, Honn KV, Chen YQ, Rice RL, Taylor JI: Suppression of W256 carcinosarcoma cell apoptosis by arachidonic and polyunsaturated fatty acids. Int J Cancer 1997;72:1078-1087.
27. Mirzoeva O, Yaqoob P, Knox K, Calder P: Inhibition of ICE-family cysteine proteases rescues murine lymphocytes from lipoxygenase inhibitor induced apoptosis. FEBS Lett 1996;396:266-270.
28. Shureiqi I, Chen D, Lee J, Yang P, Newman R, Brenner D, Lotan R, Fisher S, Lippman S: 15-LOX-1 a novel molecular target of nonsteroidal anti-inflammatory drug induced apoptosis in colorectal cancer cells. J Natl Cancer Inst 2000;92:1136-1142.
29. Hiramine C, Nakagawa T, Miyauchi A, Hojo K: Thymic nurse cells as the site of thymocyte apoptosis and apoptotic cell clearance in the thymus of cyclophosphamide-treated mice. Lab Invest 1996;75:185-201.