The effects of folic acid supplements on coagulation status in pregnancy

British Journal of Haematology

Volumn 127, Issue 2, 2004, Pages 204-208

  Deol, Paramjeet S ^a   Barnes, Tim A ^a   Dampier, Karen ^a   Pasi, K John ^a   Oppenheimer, Christina ^a   Pavord, Sue R ^a  

^a LEICESTER ROYAL INFIRMARY   (United Kingdom)

Author keywords

Folate status; Homocysteine; Hypercoagulability; Pregnancy; Thrombelastography

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID;

ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; GENE MUTATION; HOMOZYGOSITY; HUMAN; HYPERCOAGULABILITY; MAJOR CLINICAL STUDY; MATERNAL MORTALITY; PREGNANCY; PRIORITY JOURNAL; THROMBOELASTOGRAPHY; THROMBOEMBOLISM; UNITED KINGDOM; VEIN THROMBOSIS;

ADULT; BLOOD COAGULATION; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; DIETARY SUPPLEMENTS; FEMALE; FOLIC ACID; HUMANS; NUTRITIONAL STATUS; PREGNANCY; PREGNANCY COMPLICATIONS, CARDIOVASCULAR; THROMBELASTOGRAPHY; VENOUS THROMBOSIS;

EID: 5644257031     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2004.05172.x     Document Type: Article

References (33)

1. Chambers, J.C., McGregor, A., Jean-Marie, J. & Kooner, J.S. (1998) Acute hyperhomcysteinaemia and endothelial dysfunction. Lancet, 351, 36-37.
2. Coppola, A., Davi, G., De Stefano, V., Mancini, F.P., Cerbone, A.M. & DiMinno, G. (2000) Homocysteine, coagulation, platelet function, and thrombosis. Seminars in Thrombosis and Haemostasis, 26, 243-254.
3. Den Heijer, M., Rosendaal, F.R., Blom, H.J., Gerrits, W.B.J. & Bos, G.M.J. (1998) Hyperhomocysteinemia and venous thrombosis: a meta-analysis. Thrombosis and Haemostasis, 80, 874-877.
4. Doshi, S.N., Goodfellow, J., Lewis, M.J. & MCDowell, I.F.W. (1999) Homocysteine and endothelial function. Cardiovascular Research, 42, 578-582.
5. Francis, J.L., Francis, D.A. & Gunathilagan, G.J. (1994) Assessment of hypercoagulability in patients with cancer using the Sonoclot analyzer(TM) and thromboelastography. Thrombosis Research, 74, 335-346.
6. Frosst, P., Blom, H.J., Milos, R., Goyette, P., Sheppard, C.A., Matthews, R.G., Boers, G.J.H., Den Heijer, M., Kluijtmans, L.A.J., Van den Heuval, L.P. & Rozen, R. (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nature Genetics, 10, 111-113.
7. Gemmati, D., Previati, M., Serino, M.L., Moratelli, S., Guerra, S., Capitani, S., Forini, E., Ballerini, G., Scapoli, G.L. (1999) Low folate levels and thermolabile methylenetetrahydrofolate reductase as primary determinant of mild hyperhomocysteinemia in normal and thromboembolic subjects. Arteriosclerosis Thrombosis and Vascular Biology, 19, 1761-1767.
8. Gibbs, N.M., Crawford, G.P.M. & Michalopoulos, N. (1994) Thrombelastographic patterns following abdominal aortic surgery. Anaesthesia and Intensive Care, 22, 534-538.
9. Giles, W.H., Kittner, S.J., Croft, J.B., Anda, R.F., Casper, M.L. & Ford, E.S. (1998) Serum folate and risk for coronary heart disease: results from a cohort of US adults. Annals of Epidemiology, 8, 490-496.
10. Gorton, H.J., Warren, E.R., Simpson, N.A., Lyons, G.R. & Columb, M.O. (2000) Thromboelastography identifies sex-related differences in coagulation. Anesthesia and Analgesia, 91, 1279-1281.
11. Haemoscope Corporation (1999-2001) Thrombelastograph® Haemostasis Analyzer User Manual (version 3 software). Haemoscope Corporation, Morton Grove, IL.
12. Haemoscope Corporation (2001) TEG® Slide Show 2001. Haemoscope Corporation, Morton Grove, IL.
13. Homocysteine Lowering Trialists' Collaboration (1998) Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. British Medical Journal, 316, 894-898.
14. Huisman, M.V. & Rosendaal, F. (1999) Thrombophilia [Haemostasis and Thrombosis]. Current Opinion in Haematology, 6, 291-297.
15. Jacques, P.F., Bostom, A.G., William, R.R., Ellison, R.C., Eckfeldt, J.H., Rosenberg, I.H., Selhub, J. & Rozen, R. (1996) Relation between folate status, a common mutation in methylene tetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation, 93, 7-9.
16. Kang, Y.G., Martin, D.J., Marquez, J., Lewis, J.H., Bontempo, F.A. & Shaw, B.W. (1985) Intraoperative changes in blood coagulation and thromboelastographic monitoring in liver transplantation. Anesthesia and Analgesia, 64, 888-896.
17. Kelly, P., McPartlin, J., Goggins, M., Weir, D.G. & Scott, J.M. (1997) Unmetabolised folic acid in serum: acute studies in subjects consuming fortified food and supplements. American Journal of Clinical Nutrition, 65, 1790-1795.
18. Lucock, M. (2000) Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Molecular Genetics and Metabolism, 71, 121-138.
19. Maybury, H.J., Gornall, A., Kurinczuk, J.J., Konje, J.C. & Pavord, S. (2003) Use of thromboelastography to assess haemostatic function in postpartum women. British Journal of Obstetrics and Gynaecology, 110, 960-961 (Abstract).
20. Morrison, H.I., Schaubel, D., Desmeules, M. & Wigle, D.T. (1996) Serum folate and risk of fatal coronary heart disease. Journal of the American Medical Association, 275, 1893-1896.
21. Mousa, H.A. & Alfirevic, Z. (2001) Thrombophilia and adverse pregnancy outcome. Croatian Medical Journal, 42, 135-145.
22. MRC Vitamin Study Group (1991) Prevention of neural tube defects: results of the Medical Research Council vitamin study. Lancet, 338, 131-137.
23. Orlikowski, C.E.P., Rocke, D.A., Murray, W.B., Gouws, E., Moodley, J., Kenoyer, D.G. & Byrne, S. (1996) Thrombelastography changes in pre-eclampsia and eclampsia. British Journal of Anaesthesia, 77, 157-161.
24. Quéré, I., Perneger, T.V., Zittoun, J., Bellet, H., Gris, J.C., Daures, J.P., Schved, J.F., Mercier, E., Laroche, J.P., Dauzat, M., Bounameaux, H., Janben, C. & De Moerloose, P. (2002) Red blood cell methylfolate and plasma homocysteine as risk factors for venous thromboembolism: a matched case-control study. Lancet, 359, 747-752.
25. Rai, R., Tuddenham, E., Backos, M., Jivraj, S., Gaddal, S. El., Choy, S., Cork, B. & Regan, L. (2003) Thromboelastography, whole-blood haemostasis and recurrent miscarriage. Human Reproduction, 18, 2540-2543.
26. Sharma, S.K., Vera, R.L., Stegall, W.C. & Whitten, C.W. (1997a) Management of postpartum coagulopathy using thrombelastography. Journal of Clinical Anesthesia, 9, 243-247.
27. Sharma, S.K., Philip, J. & Wiley, J. (1997b) Thromboelastographic changes in healthy parturients and postpartum women. Anesthesia and Analgesia, 85, 94-98.
28. Speiss, B.D., Tuman, K.J., McCarthy, R.J., DeLaria, G.A., Schillo, R. & Ivankovich, A.D. (1987) Thromboelastography as an indicator of post cardiopulmonary bypass coagulopathies. Journal of Clinical Monitoring, 3, 25-30.
29. Stamler, J.S., Osborne, J.A., Jaraki, O., Rabbani, L.E., Mullins, M., Singel, D. & Loscalzo, J. (1993) Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. Journal of Clinical Investigation, 91, 308-318.
30. Steer, P.L. & Krantz, H.B. (1993) Thromboelastography and Sonoclot analysis in the healthy parturient. Journal of Clinical Anesthesia, 5, 419-424.
31. Title, L.M., Cummings, P.M., Giddens, K., Genest, Jr, J.J., Nassar, B.A. (2000) Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with Coronary artery disease. Journal of the American College of Cardiology, 36, 758-765.
32. Wenker, O., Wojciechowski, Z., Sheinbaum, R. & Zisman, E. (1999) Thrombelastography. International Journal of Anesthesia, 1, N3.
33. Wong, C.A., Liu, S. & Glassenburg, R. (1995) Comparison of thromboelastography with common coagulation tests in preeclamptic and healthy parturients. Regional Anesthesia, 20, 521-527.