Thrombophilia

Current Opinion in Hematology

Volumn 6, Issue 5, 1999, Pages 291-297

  Huisman, M V ^a   Rosendaal, F ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BLOOD CLOTTING FACTOR 5 LEIDEN; HOMOCYSTEINE; PROTEIN C; PROTEIN S; PROTHROMBIN;

ACTIVATED PROTEIN C RESISTANCE; ARTERY THROMBOSIS; DIABETES MELLITUS; GENE MUTATION; GEOGRAPHIC DISTRIBUTION; HEART INFARCTION; HUMAN; HYPERHOMOCYSTEINEMIA; HYPERTENSION; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SMOKING; STROKE; THROMBOPHILIA; VEIN THROMBOSIS;

FACTOR V; HUMAN; MUTATION; PROTHROMBIN; THROMBOPHILIA;

EID: 0033302797     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-199909000-00004     Document Type: Review

References (48)

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3. Laboratory evaluation and clinical characteristics of 2132 consecutive unselected patients with venous thromboembolism: Results of the Spanish multicentric study on thrombophilia
4. Deficiencies of coagulation-inhibiting and fibrinolytic proteins in outpatients with deep-vein thrombosis
5. Protein C deficiency in a controlled series of unselected outpatients: An infrequent but clear risk factor for venous thrombosis
6. Familial thrombophilia due to a previously unrecognised mechanism characterised by poor anticoagulation response to activated protein C: Prediction of a cofactor to activated protein C
7. Mutation in blood coagulation Factor V associated with resistance to activated protein C
8. Identification of the same Factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C
9. World distribution of Factor V Leiden
10. Epidemiology of Factor V Leiden: Clinical implications
11. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study
12. Different risks of thrombosis in four coagulation defects associated with inherited thrombophilias: A study in 150 families
13. The Leiden Thrombophilia Study (LETS)
14. Venous thrombosis in older people: Prevalence of the factor v gene mutation q506
15. Factor V Cambridge: A new mutation (Arg 306 → Thr) associated with resistance to activated protein C
16. A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis
17. Geographic distribution of the 20210 G to A prothrombin variant
18. Clinical studies and thrombin generation in patients homozygous or heterozygous for the G20210A mutation in the prothrombin gene
19. Homozygous G20210A transition in the prothrombin gene associated with severe venous thrombotic disease: Two cases in a French family
20. Homozygous G20210A prothrombin gene mutation without thromboembolic events: A case report
21. Inherited thrombophilia: Part 2
22. High risk of cerebral-vein thrombosis in carriers of a prothrombin gene mutation and in users of oral contraceptives
23. Case-control study of risk of cerebral sinus thrombosis in oral contraceptive users who are carriers of hereditary prothrombotic conditions
24. Prothrombin gene G20210 → A transition is a risk factor for cerebral venous thrombosis
25. The risk of early recurrent venous thromboembolism after oral anticoagulant therapy in patients with the G20210A transition in the prothrombin gene
26. A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism
27. Factor V Leiden and risks of recurrent idiopathic venous thromboembolism
28. The risk of recurrent venous thromboembolism in patients with and without Factor V Leiden
29. Long-term, low-dose warfarin among venous thrombosis patients with and without Factor V Leiden mutation: Rationale and design for the prevention of recurrent venous thromboembolism (PREVENT) trial
30. Interaction of coagulation defects and cardiovascular risk factors. Increased risk of myocardial infarction associated with Factor V Leiden or prothrombin 20210A
31. A common prothrombin variant (20210A) increases the risk of myocardial infarction in young women
32. Factor V Leiden (resistance to protein C) increases the risk of myocardial infarction in young women
33. Factor V Leiden is not a risk factor for arterial vascular disease in the elderly: Results from the cardiovascular health study
34. Risk of stroke in young women and two prothrombotic mutations: Factor V Leiden and prothrombin gene variant (G20210A)
35. APC resistance as an additional risk factor for thrombosis in protein C-deficient families
36. Resistance to activated protein C as an additional factor for thrombosis in protein C deficient families
37. Factor V Leiden (FV R506Q) in families with inherited antithrombin deficiency
38. The prothrombin 20210 A allele is frequently combined in young carriers of the Factor V Arg 506 to Gin mutation with venous thrombophilia
39. The A20210 allele of the prothrombin gene is frequently associated with the Factor V Arg 506 to Gin mutation but not with protein S deficiency in thrombophilic families
40. The A20210 allele of the prothrombin gene is not frequently associated with the Factor V Arg 506 to Gin mutation in thrombophilic patients
41. Hyperhomocysteinemia and venous tnrombosis: A meta-analysis
42. A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
43. Thermolabile methylenetetrahydrofolate reductase and Factor V Leiden in the risk of deep-vein thrombosis
44. Effect of the MTHFRC677T variant on risk of venous thromboembolism: Interaction with Factor V Leiden and prothrombin (F2G20210A) mutations
45. The methylenetetrahydrofolate reductase TT677 genotype is associated with venous thrombosis independently of the coexistence of the FV Leiden and the prothrombin 20210A mutation
46. Interrelation of hyperhomocysteinemia, Factor V Leiden and the risk of future venous thromboembolism
47. Hyperhomocysteinemia as a risk factor for deep-vein thrombosis
48. Venous thrombosis: A multicausal disease