Escherichia coli mazEF-mediated cell death as a defense mechanism that inhibits the spread of phage P1

Molecular Genetics and Genomics

Volumn 272, Issue 2, 2004, Pages 227-234

  Hazan, R ^a   Engelberg Kulka, H ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Bacterial programmed cell death; Bacteriophage P1; Multicellular behavior of bacteria; Phage exclusion

Indexed keywords

ANTITOXIN; TOXIN;

ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIOPHAGE; BACTERIUM CULTURE; CELL DEATH; CELL VIABILITY; CHROMOSOME; CONTROLLED STUDY; CYTOLYSIS; DEFENSE MECHANISM; ESCHERICHIA COLI; GENE EXPRESSION; MAZEF GENE; NONHUMAN; PRIORITY JOURNAL; PROPHAGE;

APOPTOSIS; BACTERIOPHAGE P1; DNA-BINDING PROTEINS; ENDORIBONUCLEASES; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENES, BACTERIAL; LYSOGENY; PROPHAGES; VIRUS ACTIVATION; VIRUS REPLICATION;

ANIMALIA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA; PROKARYOTA; VIR;

EID: 5644239810     PISSN: 16174615     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00438-004-1048-y     Document Type: Article

References (42)

1. Aizenman E, Engelberg-Kulka H, Glaser G (1996) An Escherichia coli chromosomal "addiction module" regulated by guanosine 3′,5′-bispyrophosphate: a model for programmed bacterial cell death. Proc Natl Acad Sci USA 93:6059-6063
2. Allsopp TE, Fazakerley JK (2000) Altruistic cell suicide and the specialized case of the virus-infected nervous system. Trends Neurosci 23:284-290
3. Bech FW, Jorgensen ST, Diderichsen B, Karlstrom OH (1985) Sequence of the relB transcription unit from Escherichia coli and identification of the relB gene. EMBO J 4:1059-1066
4. Bertani G (2004) Lysogeny at mid-twentieth century: P1, P2, and other experimental systems. J Bacteriol 186:595-600
5. Casadaban MJ, Cohen SA (1979) Lactose genes fused to exogenous promoters in one step using a Mu-lac bacteriophage: in vivo probe for transcriptional control sequence. Proc Natl Acad Sci USA 76:4530-4533
6. Cashel M, Gentry DR, Hernandez VZ, Vinella D (1996) The stringent response. In: Neidhardt FC, Curtiss III R, Ingraham JL, Lin ECC, Low KB, Magasanik B, Reznikoff WR, Riley M, Schaechter M, Umbarger HE (eds) Escherichia coli and Salmonella: cellular and molecular biology. American Society for Microbiology, Washington, D.C., pp 1458-1496
7. Christensen SK, Pedersen K, Hensen FG, Gerdes K (2003) Toxin-antitoxin loci as stress-response elements: ChpAK/MazF and ChpBK cleave translated mRNAs and are counteracted by tmRNA. J Mol Biol 332:809-819
8. Cooper TF, Heinemann JA (2000) Postsegregational killing does not increase plasmid stability but acts to mediate the exclusion of competing plasmids. Proc Natl Acad Sci USA 97:12643-12648
9. Couturier M, Bahassi EM, Van Melderen L (1998) Bacterial death by DNA gyrase poisoning. Trends Microbiol 6:269-275
10. Engelberg-Kulka H, Glaser G (1999) Addiction modules and programmed cell death and antideath in bacterial cultures. Annu Rev Microbiol 53:43-70
11. Engelberg-Kulka H, Reches M, Narasimhan S, Schoulaker-Schwarz R, Klemes Y, Aizenman E, Glaser G (1998) rexB of bacteriophage lambda is an anti-cell death gene. Proc Natl Acad Sci USA 95:15481-15486
12. Engelberg-Kulka H, Sat B, Hazan R (2001) Bacterial programmed cell death and antibiotics. ASM News 67:617-625
13. Engelberg-Kulka H, Sat B, Reches M, Amitai S, Hazan R (2004) Bacterial programmed cell death as a target for antibiotics. Trends Microbiol 12:66-71
14. Gotfredsen M, Gerdes K (1998) The Escherichia coli relBE genes belong to a new toxin-antitoxin gene family. Mol Microbiol 29:1065-1076
15. Grady R, Hayes F (2003) Axe-Txe, a broad-spectrum proteic toxin-antitoxin system specified by a multidrug-resistant clinical isolate of Enterococcus faecium. Mol Microbiol 47:1419-1432
16. Hazan R, Sat B, Reches M, Engelberg-Kulka H (2001) Postsegregational killing mediated by the Pl phage "addiction module" phd-doc requires the Escherichia coli programmed cell death system mazEF. J Bacteriol 183:2046-2050
17. Hazan R, Sat B, Engelberg-Kulka H (2004) Escherichia coli mazEF -mediated cell death is triggered by various stressful conditions. J Bacteriol 186:3663-3669
18. Hayes F (2003) Toxin-antitoxins: plasmid maintenance, programmed cell death, and cell cycle arrest. Science 301:1496-1499
19. Iida S, Arber W (1977) Plaque forming specialized transducing phage P1: isolation of P1 CmSmSu, a precursor of P1 Cm. Mol Gen Genet 153:259-269
20. Jensen RB, Gerdes K (1995) Programmed cell death in bacteria: proteic plasmid stabilization systems. Mol Microbiol 17:205-210
21. Lehnherr H, Magnuson E, Jafri S, Yarmolinsky MB (1993) Plasmid addiction genes of bacteriophage P1: doc, which causes cell death on curing of prophage, and phd, which prevents host death when prophage is retained. J Mol Biol 233:414-428
22. Lewis K (2000) Programmed death in bacteria. Microbiol Mol Biol Rev 64:503-514
23. Maclean DJ, Sargent JA, Tommerup IC, Ingram DS (1974) Hypersensitivity as the primary event in resistance to fungal parasites. Nature 249:186-187
24. Marianovsky I, Aizenman E, Engelberg-Kulka H, Glaser G (2001) The regulation of the Escherichia coli mazEF promoter involves an unusual alternating palindrome. J Biol Chem 276:5975-5984
25. Masuda Y, Miyakawa K, Nishimura Y, Ohtsubo E (1993) chpA and chpB, Escherichia coli chromosomal homologs of the pem locus responsible for stable maintenance of plasmid R100. J Bacteriol 175:6850-6856
26. Metzger S, Dror IB, Aizenman E, Schreiber G, Toone M, Friesen JD, Cashel M, Glaser G (1988) The nucleotide sequence and characterization of the relA gene of Escherichia coli. J Biol Chem 263:15699-15704
27. Miller JH (1972) Generalized transduction: use of P1 in strain construction. In: Experiments in molecular genetics. Cold Spring Harbor Laboratory, Cold Sprinmg Harbor, N.Y., pp 201-205
28. Mittenhuber G (1999) Occurrence of mazEF -like antitoxin/toxin systems in bacteria. J Mol Microbiol Biotechnol 1:295-302
29. Munoz-Gomez AG, Santos-Sierra S, Berzal-Herranz A, Lemonner M, Diaz-Orejas R (2004) Insight into the specificity of RNA cleavage by the Escherichia coli MazF toxin. FEBS Lett 567:316-320
30. Nystrom T (1999) Starvation, cessation of growth and bacterial aging. Curr Opin Microbiol 2:214-219
31. Pecota DC, Wood TK (1996) Exclusion of T4 phage by the hok/sok killer locus from plasmid R1. J Bacteriol 178:2044-2050
32. Rice KC, Bayles KW (2003) Death's toolbox: examining the molecular components of bacterial programmed cell death. Mol Microbiol 50:729-738
33. Russel M, Model P (1984) Replacement of the fip gene of Escherichia coli by an inactive gene cloned on a plasmid. J Bacteriol 159:1034-1039
34. Sat B, Hazan R, Fisher T, Khaner H, Glaser G, Engelberg-Kulka H (2001) Programmed cell death in Escherichia coli: some antibiotics can trigger mazEF lethality. J Bacteriol 183:2041-2045
35. Sat B, Reches M, Engelberg-Kulka H (2003) The Escherichia coli mazEF suicide module mediates thymineless death. J Bacteriol 185:1803-1807
36. Shapiro JA (1998) Thinking about bacterial populations as multicellular organisms. Annu Rev Microbiol 52:81-104
37. Shub DA (1994) Bacterial viruses. Bacterial altruism? Curr Biol 4:555-556
38. Snyder L (1995) Phage-exclusion enzymes: a bonanza of biochemical and cell biology reagents? Mol Microbiol 15:415-420
39. Snyder L, Kaufmann G (1994) T4 phage exclusion mechanisms. In: Karam JD (ed) Molecular biology of bacteriophage T4. American Society for Microbbiology, Washington D.C., pp 391-396
40. Yanisch-Perron C, Vieira J, Messing J (1985) Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13 mp18 and pUC19 vectors. Gene 33:103-119
41. Yarmolinsky MB (1995) Programmed cell death in bacterial populations. Science 267:836-837
42. Zhang Y, Zhang J, Hoeflich KP, Ikura M, Quing G, Inouye M (2003) MazF cleaves cellular mRNA specifically at ACA to block protein synthesis in Escherichia coli. Mol Cell 12:913-923